Results 281 to 290 of about 5,793,605 (328)

Comparative Bactericidal Activity of Fluoroquinolones Against Clinical Isolates Resistant to Fluoroquinolones

Journal of Chemotherapy, 2003
The bactericidal activity of levofloxacin, ciprofloxacin, moxifloxacin and norfloxacin against clinical isolates conventionally classified as resistant to fluoroquinolones were compared at their maximum concentrations in serum, urine (except moxifloxacin) and bronchial mucosa (except norfloxacin).
L. Drago, E. De Vecchi, L. Nicola, M. Valli, F. Marchetti, M.R. Gismondo   +5 more
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Mechanisms of Resistance to Fluoroquinolones

1998
In the early 1980s, when fluoroquinolones were an area of rapid development and considerable pharmaceutical company interest, it was commonly believed that resistance to fluoroquinolones would not become a problem, as it had with previous classes of antibiotics, as fluoroquinolone-resistant Escherichia coli could only be selected with great difficulty ...
M. J. Everett, L. J. V. Piddock
openaire   +1 more source

Emerging Resistance to Fluoroquinolones in Staphylococci: An Alert

Annals of Internal Medicine, 1991
The fluoroquinolones are orally administered antimicrobial agents introduced in the mid-1980s. Although they are particularly effective for treating gram-negative bacillary infections, some agents,...
M, Trucksis, D C, Hooper, J S, Wolfson
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Fluoroquinolone Resistance in Bacteria

2009
FQs are some of the most widely prescribed antimicrobial agents. Of the total sales of $42 billion from antibiotics worldwide in 2009, FQs represented 17 % of the market, generating $7 billion in global sales (Furiex Pharmaceuticals; http://www.furiex.com).
Varsha V. Moudgal, Glenn W. Kaatz
openaire   +1 more source

Fluoroquinolone resistance in ophthalmology and the potential role for newer ophthalmic fluoroquinolones

Survey of Ophthalmology, 2004
The three topical ophthalmic fluoroquinolones recently introduced into the U.S. market--levofloxacin, gatifloxacin, and moxifloxacin--offer several advantages over the previously available fluoroquinolones (norfloxacin 0.3%, ciprofloxacin 0.3%, and ofloxacin 0.3%).
openaire   +2 more sources

Insight into the fluoroquinolone resistance, sources, ecotoxicity, and degradation with special emphasis on ciprofloxacin

, 2021
K. K. Sodhi, D. Singh
semanticscholar   +1 more source

Avoiding fluoroquinolone resistance

Postgraduate Medicine, 1997
The therapeutic usefulness of fluroquinolones for serious and difficult-to-treat infections is well documented. However, with increasing reports of organisms becoming resistant to the agents (most often the pseudomonads, staphylococci, and streptococci), the usefulness of this class of antibiotics is being threatened.
openaire   +2 more sources

Mechanisms of Resistance to Fluoroquinolones

Drugs, 1995
This paper gives an update on the mechanisms of bacterial resistance to fluoroquinolones. The laboratory techniques currently used to determine the mechanism(s) of resistance are outlined, including the use of restriction fragment length polymorphism and single-stranded conformational polymorphism analysis of mutations in gyrA. Alterations in gyrA have
openaire   +2 more sources

Resistance to Quinolones and Fluoroquinolones

1989
The quinolone class of oral antimicrobial agents has enjoyed rapid expansion and development over recent years and a revival in interest in the earlier agents nalidixic and oxolinic acid. The quinolone class (which includes 4-pyridone antibacterials) share the 4-quinolone nucleus and also a carboxylic acid substituent at position 3 (Fig. 1). During the
openaire   +1 more source

Bacterial resistance to fluoroquinolones: Lessons to be learned

Infection, 1994
Resistance to fluoroquinolone antibacterials has emerged in a limited form, largely amongst certain specific species and often restricted to single clones of these pathogens. Mediated by chromosomal mutation, the major mechanisms are alterations in gyrase subunits and reduced penetration associated with decreased outer membrane protein production ...
openaire   +2 more sources