Results 261 to 270 of about 5,793,605 (328)

Molecular Mechanisms of Fluoroquinolone Resistance in Klebsiella

open access: yesCurrent Drug Target -Infectious Disorders, 2004
Klebsiella are well-recognized community and nosocomial pathogens responsible for septicemias, urinary tract infections, pneumonia, and soft tissue infections. The emergence of multi-drug resistant Klebsiella is becoming a global concern. Since fluoroquinolones are excellent antibiotics for clinical therapy of complicated infections, their consumptions
Yun-Liang, Yang   +2 more
openaire   +3 more sources

Fluoroquinolone Residues in the Environment Rapidly Induce Heritable Fluoroquinolone Resistance in Escherichia coli.

Environmental Science and Technology, 2023
Extensive antibiotic use increases the environmental presence of their residues and may accelerate the development of antibiotic resistance, although this remains poorly understood at environmentally relevant concentrations.
He-Bin Liang   +4 more
semanticscholar   +1 more source

Individualised treatment of Mycoplasma genitalium infection-incorporation of fluoroquinolone resistance testing into clinical care.

Lancet. Infectious Diseases (Print), 2022
Mycoplasma genitalium is an emerging global health threat, due to an alarming rise in antimicrobial resistance. Although individualised treatment approaches have been successfully adopted for macrolides, treatment is complicated by rising rates of ...
Emma L. Sweeney   +3 more
semanticscholar   +1 more source

Fluoroquinolone antibiotics: Occurrence, mode of action, resistance, environmental detection, and remediation - A comprehensive review.

Environmental Pollution, 2022
Antibiotics play an essential role in the medical healthcare world, but their widespread usage and high prevalence have posed negative environmental consequences.
Sunidhi Bhatt, Subhankar Chatterjee
semanticscholar   +1 more source

Fluoroquinolone Use and Fluoroquinolone Resistance: Is There an Association?

Clinical Infectious Diseases, 1994
In an assessment of potential risk factors for nosocomial infections caused by fluoroquinolone-resistant gram-negative organisms, 68 patients who developed a nosocomial infection caused by a fluoroquinolone-resistant gram-negative bacillus were compared with 191 patients who developed a nosocomial infection caused by a fluoroquinolone-susceptible gram ...
P, Richard   +6 more
openaire   +2 more sources

Fluoroquinolones, tuberculosis, and resistance

The Lancet Infectious Diseases, 2003
Although the fluoroquinolones are presently used to treat tuberculosis primarily in cases involving resistance or intolerance to first-line antituberculosis therapy, these drugs are potential first-line agents and are under study for this indication.
Amy Sarah, Ginsburg   +2 more
openaire   +2 more sources

Fluoroquinolones: Action and Resistance

Current Topics in Medicinal Chemistry, 2003
Fluoroquinolones trap gyrase and topoisomerase IV on DNA as ternary complexes that block the movement of replication forks and transcription complexes. Studies with resistant mutants indicate that during complex formation quinolones bind to a surface alpha-helix of the GyrA and ParC proteins.
Karl, Drlica, Muhammad, Malik
openaire   +2 more sources

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