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Efflux Pump Induction by Quaternary Ammonium Compounds and Fluoroquinolone Resistance in Bacteria
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Streptococcus pneumoniae resistance to fluoroquinolones
The Lancet, 19961 Child J, Andrews J, Boswell F, Brenwald NP, Wise R. The in vitro activity of CP 99,219, a new naphthyridone antimicrobial agent. J Antimicrob Chemother 1995; 35: 869–76. 2 Petersen U, Bremm KD, Dalhoff A, et al. Synthesis in BAY 12-8039, a new 8-methoxy-quinolone. Abst no F1.
R, Wise, N, Brenwald, M, Gill, A, Fraise
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Occurrence of fluoroquinolones and fluoroquinolone-resistance genes in the aquatic environment
Science of The Total Environment, 2013Fluoroquinolones (FQs) have been detected in aquatic environments in several countries. Long-term exposure to low levels of antimicrobial agents provides selective pressure, which might alter the sensitivity of bacteria to antimicrobial agents in the environment. Here, we examined FQ levels and the resistance of Escherichia coli (E.
Fumie, Adachi +3 more
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Journal of food microbiology, 2019
Vibrio parahaemolyticus is the leading cause of foodborne bacterial poisoning in China. The aim of this research is to conduct a study on the prevalence, virulence, and antimicrobial resistance of V.
T. Lei +11 more
semanticscholar +1 more source
Vibrio parahaemolyticus is the leading cause of foodborne bacterial poisoning in China. The aim of this research is to conduct a study on the prevalence, virulence, and antimicrobial resistance of V.
T. Lei +11 more
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Mechanisms of fluoroquinolone resistance
Drug Resistance Updates, 1999Mechanisms of bacterial resistance to fluoroquinolones fall into two principal categories, alterations in drug target enzymes and alterations that limit permeation of drug to the target, both resulting from chromosomal mutations. No specific resistance mechanisms of quinolone degradation or modification have been found.
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Bacterial Resistance to Fluoroquinolones
Clinical Infectious Diseases, 1988Fluoroquinolones inhibit bacteria by interacting with the A subunit of DNA gyrase. Resistance to older agents such as nalidixic acid was due to mutations in the gyrA gene. Resistance to the new fluoroquinolones (e.g., norfloxacin, enoxacin, ofloxacin, pefloxacin, and ciprofloxacin) as a consequence of spontaneous single-step mutation occurs at a low ...
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Journal of Antimicrobial Chemotherapy, 2018
Objectives As information on Ureaplasma spp. and Mycoplasma hominis resistance is currently limited, the aim of this study was to investigate the susceptibility of Ureaplasma spp. and M. hominis to tetracyclines and fluoroquinolones in France.
A. Meygret +4 more
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Objectives As information on Ureaplasma spp. and Mycoplasma hominis resistance is currently limited, the aim of this study was to investigate the susceptibility of Ureaplasma spp. and M. hominis to tetracyclines and fluoroquinolones in France.
A. Meygret +4 more
semanticscholar +1 more source
Resistance to Ciprofloxacin and the New Fluoroquinolones
Journal of Chemotherapy, 2000Resistance to ciprofloxacin has generally remained low in the UK. A low rate of resistance development in vitro has been suggested for the newer fluoroquinolones such as grepafloxacin and trovafloxacin. Levofloxacin is likely to have a pattern of development of resistance similar to that of ofloxacin.
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Journal of Infection and Chemotherapy, 2018
To clarify the status of macrolide and fluoroquinolone resistance of clinical strains of Mycoplasma genitalium in Japan, we amplified portions of the gyrA, parC, and 23S rRNA genes from DNAs in 627 first-voided urine specimens collected from men with M ...
T. Deguchi +8 more
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To clarify the status of macrolide and fluoroquinolone resistance of clinical strains of Mycoplasma genitalium in Japan, we amplified portions of the gyrA, parC, and 23S rRNA genes from DNAs in 627 first-voided urine specimens collected from men with M ...
T. Deguchi +8 more
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Fluoroquinolones: mechanisms of action and resistance
International Journal of Antimicrobial Agents, 1993The mechanism of action and the mechanism of resistance of the 4-quinolones are complex and poorly understood. The first barrier these molecules must cross is the bacterial outer membrane. In gram-negative species, 4-quinolones pass through either the porins or lipopolysaccharides (or both) depending on their chemical nature. The cellular target is the
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