Results 191 to 200 of about 56,658 (237)
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Infectious Disease Clinics of North America, 1995
Since the introduction of the floroquinolones for clinical use in the late 1980s, they have been used successfully for a large number of clinical situations. As experience accumulates, the indications and optimal use of these agents gradually become more clear.
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Since the introduction of the floroquinolones for clinical use in the late 1980s, they have been used successfully for a large number of clinical situations. As experience accumulates, the indications and optimal use of these agents gradually become more clear.
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Mayo Clinic Proceedings, 1999
The quinolones are broad-spectrum antibacterial agents that have a novel mechanism of action. As synthetic compounds, these agents have been developed extensively to optimize antimicrobial activity, pharmacokinetic properties, and drug safety. Although earlier quinolones were effective only in the genitourinary and gastrointestinal tracts and only had ...
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The quinolones are broad-spectrum antibacterial agents that have a novel mechanism of action. As synthetic compounds, these agents have been developed extensively to optimize antimicrobial activity, pharmacokinetic properties, and drug safety. Although earlier quinolones were effective only in the genitourinary and gastrointestinal tracts and only had ...
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Infectious Disease Clinics of North America, 2004
This article discusses the newer fluoroquinolones in detail with respect to their pharmacokinetics, pharmacodynamics, safety, and spectrum of in vitro activity. The newer agents are compared and contrasted with the older ones, particularly ciprofloxacin.
Judith A, O'Donnell, Steven P, Gelone
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This article discusses the newer fluoroquinolones in detail with respect to their pharmacokinetics, pharmacodynamics, safety, and spectrum of in vitro activity. The newer agents are compared and contrasted with the older ones, particularly ciprofloxacin.
Judith A, O'Donnell, Steven P, Gelone
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Fluoroquinolones in Paediatrics
Paediatric Drugs, 2001The fluoroquinolones are an important group of antibiotics, which are widely used in adult patients because of their high penetration in tissues and bactericidal activity. However, they are not licensed for paediatric use (except the limited indication of Pseudomonas infection in cystic fibrosis) because of their potential to cause joint toxicity ...
D, Gendrel, F, Moulin
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Fluoroquinolones in the treatment of meningitis
Current Infectious Disease Reports, 2003The continuous increase of resistant pathogens causing meningitis has limited the efficacy of standard therapeutic regimens. Due to their excellent activity in vitro and their good penetration into the cerebrospinal fluid (CSF), fluoroquinolones appear promising for the treatment of meningitis caused by gram-negative microorganisms, ie, Neisseria ...
Cottagnoud P, Täuber MG
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Photophysics and photochemistry of fluoroquinolones
Chemical Society Reviews, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
A Albini, S Monti
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The Role of the Fluoroquinolones
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1992Over the past decade, the quinolone antimicrobial class has enjoyed a renaissance with the emergence of the fluoroquinolone subclass. Norfloxacin, ciprofloxacin, ofloxacin, enoxacin, and lomefloxacin have the advantages of broad antimicrobial activity profiles including gram‐positive and ‐negative aerobes, favorable pharmacokinetic
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Drug and Therapeutics Bulletin, 1994
Two fluoroquinolone antibiotics, ciprofloxacin (Ciloxan - Alcon) and ofloxacin (Exocin - Allergan), are available in the UK as topical preparations for the eye.* Ciprofloxacin eyedrops are licensed for the treatment of "corneal ulcers and superficial infections of the eye", and ofloxacin eyedrops for "external ocular infections (such as conjunctivitis ...
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Two fluoroquinolone antibiotics, ciprofloxacin (Ciloxan - Alcon) and ofloxacin (Exocin - Allergan), are available in the UK as topical preparations for the eye.* Ciprofloxacin eyedrops are licensed for the treatment of "corneal ulcers and superficial infections of the eye", and ofloxacin eyedrops for "external ocular infections (such as conjunctivitis ...
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Drugs, 2001
The fluoroquinolones have become widely used antibacterial agents in the treatment of ocular infections, with topical, intravitreal and systemic routes of administration being used. In general, fluoroquinolones (such as ciprofloxacin, ofloxacin, lomefloxacin and norfloxacin) have good activity against gram-negative and gram-positive bacteria ...
A, Smith +3 more
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The fluoroquinolones have become widely used antibacterial agents in the treatment of ocular infections, with topical, intravitreal and systemic routes of administration being used. In general, fluoroquinolones (such as ciprofloxacin, ofloxacin, lomefloxacin and norfloxacin) have good activity against gram-negative and gram-positive bacteria ...
A, Smith +3 more
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Drugs, 1995
The main types of adverse effects associated with quinolones are uncommon and reversible and vary in frequency among different agents. Phototoxicity appears more frequent with lomefloxacin than with some other quinolones. Three mechanisms have been proposed to explain the neurotoxic effects, including rare proconvulsant activity, associated with ...
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The main types of adverse effects associated with quinolones are uncommon and reversible and vary in frequency among different agents. Phototoxicity appears more frequent with lomefloxacin than with some other quinolones. Three mechanisms have been proposed to explain the neurotoxic effects, including rare proconvulsant activity, associated with ...
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