Results 121 to 130 of about 290,304 (371)

The role of NLRP3 inflammasome in 5-fluorouracil resistance of oral squamous cell carcinoma

Journal of experimental & clinical cancer research : CR, 2017
5-Fluorouracil (5-FU) is a widely used drug for the therapy of cancer. However, the chemoresistance of tumor cells to 5-FU usually limits its clinical effectiveness.
Xiaodong Feng, Q. Luo, Han Zhang, Hantao Wang, Wantao Chen, Guangxun Meng, Fuxiang Chen   +6 more
semanticscholar   +1 more source

Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms: relationships with 5-fluorouracil sensitivity [PDF]

, 2004
M-C Etienne, Karine Ilc, J. L. Formento, Pierre Laurent‐Puig, Patricia Formento, S. Chéradame, J-L Fischel, G. Milano   +7 more
openalex   +1 more source

Potential Anti-Tumor Drug: Co-Crystal 5-Fluorouracil-nicotinamide [PDF]

, 2020
Zhu-Yan Zhang, Nan Yu, Chang Xue, Shan Gao, Zhao‐Peng Deng, Min Li, Cong Liu, John J. Castellot, Siying Han   +8 more
openalex   +1 more source

Exercise and Nutrition Prehabilitation Program During Preoperative Chemotherapy Followed by Esophagectomy in Older Patients With Esophageal Cancer: A Randomized Clinical Trial

Annals of Gastroenterological Surgery, EarlyView.
This prospective randomized trial evaluated whether prehabilitation, exercise and nutrition intervention, enhance skeletal muscle mass during neoadjuvant chemotherapy in older patients with esophageal cancer undergoing esophagectomy. We also investigated whether exercise alone was sufficient to increase skeletal muscle mass, and whether nutritional ...
Keijiro Sugimura, Takashi Kanemura, Tomohira Takeoka, Takahito Sugase, Norihiro Matsuura, Kazuyoshi Yamamoto, Masahiko Yano, Hiroshi Miyata   +7 more
wiley   +1 more source

Insights into the Controlled Formation of Zr‐Based Metal–Organic Gels: Linking Macroscopic Properties with Molecular Information from Solution State NMR

Angewandte Chemie, EarlyView.
Real time STD/SDTD NMR unveils water structuring during UiO‐66 gelation under mild, acid‐free conditions compatible with biomolecule encapsulation. This approach bridges molecular‐scale solvent ordering with macroscopic gel properties, unlocking mechanistic insight for the rational design of MOF gels.
Juan C. Muñoz‐García, Francisco G. Moscoso, Elena M. Sánchez‐Fernández, Jenifer Santos, Jesús Angulo, Carolina Carrillo‐Carrión   +5 more
wiley   +2 more sources

Drugtamer‐PROTAC Conjugation Strategy for Targeted PROTAC Delivery and Synergistic Antitumor Therapy

Advanced Science
Proteolysis‐targeting chimeras (PROTACs) have emerged as a promising strategy for targeted protein degradation and drug discovery. To overcome the inherent limitations of conventional PROTACs, an innovative drugtamer‐PROTAC conjugation approach is ...
Shipeng He, Yuxin Fang, Yaojin Zhu, Ziyang Ma, Guoqiang Dong, Chunquan Sheng   +5 more
doaj   +1 more source

Stimuli-responsive polyvinylpyrrolidone-NIPPAm-lysine graphene oxide nano-hybrid as an anticancer drug delivery on MCF7 cell line

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Despite the advances in the development of chemotherapeutic agents, resistance to chemotherapy and adverse side effects are still big challenges against successful cancer treatment.
Maryam Ashjaran, Mirzaagha Babazadeh, Abolfazl Akbarzadeh, Soodabeh Davaran, Roya Salehi   +4 more
doaj   +1 more source

Long-term bresults of radiotherapy combined with nedaplatin and 5-fluorouracil for postoperative loco-regional recurrent esophageal cancer: update on a phase II study [PDF]

, 2012
Keiichi Jingu, Haruo Matsushita, Ken Takeda, Rei Umezawa, Chiaki Takahashi, Toshiyuki Sugawara, Masaki Kubozono, Keiko Abe, Takaya Tanabe, Yuko Shirata, Takaya Yamamoto, Youjirou Ishikawa, Kenji Nemoto   +12 more
openalex   +1 more source

Prognostic and Predictive Role of Lymph Node Count in Stage II Colon Cancer: A Retrospective Analysis of a Japanese Nationwide Cohort

Annals of Gastroenterological Surgery, EarlyView.
This study analyzed over 3500 patients with stage II colon cancer treated with D3 lymphadenectomy, to reassess the prognostic value of number of harvested lymph node and their role in predicting benefit from adjuvant chemotherapy using a Japanese nationwide cohort.
Kozo Kataoka, Akira Ouchi, Kanae Takahashi, Kazuma Ito, Manabu Shiozawa, Kenta Iguchi, Takashi Akiyoshi, Takefumi Yoshida, Masataka Ikeda, Eiji Shinto, Yasuyuki Takamizawa, Yoichi Ajioka, Hirotoshi Kobayashi, Yukihide Kanemitsu   +13 more
wiley   +1 more source

Study of the antimutagenic effects of plant polyphenols under the action of genotoxicants

Journal of Education, Health and Sport, 2019
In the test of dominant lethal germ cell mutations in male rats, the effect of phenobarbital and fluorouracil genotoxicants and their combined administration with the biotrit-C preparation, obtained from wheat seedlings and containing plant polyphenols ...
V. S. Ivanov
doaj