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Annals of Pharmacotherapy, 1994
OBJECTIVE: To review the clinical manifestations, postulated mechanisms, and therapeutic implications of fluorouracil-induced cardiac toxicity. DATA SOURCE: A MEDLINE search was used to identify pertinent literature. STUDY SELECTION: Studies and case reports on fluorouracil cardiotoxicity were identified through a MEDLINE search.
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OBJECTIVE: To review the clinical manifestations, postulated mechanisms, and therapeutic implications of fluorouracil-induced cardiac toxicity. DATA SOURCE: A MEDLINE search was used to identify pertinent literature. STUDY SELECTION: Studies and case reports on fluorouracil cardiotoxicity were identified through a MEDLINE search.
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Cardiotoxicity of 5-Fluorouracil
Cardiovascular & Hematological Agents in Medicinal Chemistry, 2006Cardiac side effects of the cytostatic agent 5-fluorouracil (5-FU) have an incidence of 1.2-7.6%. Potentially, arrhythmias, myocardial infarction and sudden cardiac death could occur. Life-threatening cardiotoxicity is rarely observed with a frequency
J. R. Schaefer +4 more
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Myocardiotoxicity of 5 Fluorouracil
Intensive Care Medicine, 1988We report a case of specific myocardiotoxicity due to 5 F.U. not previously described in man. A 41-year-old man was admitted to the ICU for heart and renal failure, appearing 24 h after 5 days treatment with 5 F.U. and cis-platinum. Dopamine was necessary to maintain blood pressure. Two-D echocardiography and a right heart catheterisation confirmed the
A Caillette +4 more
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Fluorouracil-Induced Hyperpigmentation
New England Journal of Medicine, 2020Fluorouracil-Induced Hyperpigmentation A 57-year-old man received FOLFOX (leucovorin, fluorouracil, and oxaliplatin) as treatment for colon cancer.
Jordan K. Schaefer, Nithya Ramnath
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Desensitization to 5-Fluorouracil
Allergy and Asthma Proceedings, 1999Anaphylactic reactions to 5-fluorouracil (5-FU) are uncommon. We report a 40-year-old female with adenocarcinoma of the ovary who had two reactions immediately after being infused with 5-FU. The second reaction occurred despite prophylaxis with steroids and antihistamines.
Kirk Sperber, Thomas Eppinger
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The Prodrugs of 5-Fluorouracil
Current Medicinal Chemistry-Anti-Cancer Agents, 2002Although 5-fluorouracil (FU) was first introduced in 1957, it remains an essential part of the treatment of a wide range of solid tumors. FU has antitumor activity against epithelial malignancies arising in the gastrointestinal tract, breast as well as the head and neck, with single-agent response rates of only 10-30%.
R. Martino +2 more
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Fluorouracil and Colorectal Cancer
JAMA: The Journal of the American Medical Association, 1977To the Editor.— The disagreement between Moertel (236:1935, 1976) and Li (237:872, 1977) regarding the value of fluorouracil as an adjuvant agent can be reconciled if the factors of angiogenesis and selective solubilization of fluorouracil are taken into account.
Bernard Ecanow +2 more
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Fluorouracil and Suprachoroidal Hemorrhage
Archives of Ophthalmology, 1987To the Editor. —Frenkel and Shin 1 have presented "a somewhat different picture... regarding the predisposing factors... in delayed suprachoroidal hemorrhages." While their impression that aphakia is an important predisposing factor concurs with previous reports, 2-4 we find little support for their assertion that the use of fluorouracil is a risk ...
Michael G. Gressel, Richard K. Parrish
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Administration of Fluorouracil
JAMA, 1963To the Editor: —This letter is written to challenge the conclusions drawn by Dr. Lemon and associates in their article "Decreased Intoxication by Fluorouracil When Slowly Administered in Glucose" ( JAMA 185 :1012 [Sept 28] 1963). Since acceptance of the conclusions of these authors could lead to widespread "office practice" use of this method of ...
Charles G. Moertel +1 more
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Immunosuppression by 5-fluorouracil
Cancer, 1970Twelve patients with neoplasia undergoing therpay with 5-fluorouracil (5-FU) were immunized with Escherichia coli Vi antigen and tetanus toxoid to test the primary and secondary humoral immune responses. Skin sesitization was attempted with 2,4-dinitrochlorobenzene, and a battery of conmon microbial skin tests were applied during and after therapy ...
Malcolm S. Mitchell, Ronald C. Deconti
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