Frontiers in Cellular Neuroscience, 2017 Previously, we reported that fluoxetine acts on 5-HT2B receptor and induces epidermal growth factor receptor (EGFR) transactivation in astrocytes. Recently, we have found that chronic treatment with fluoxetine regulates Caveolin-1 (Cav-1)/PTEN/PI3K/AKT ...
Baoman Li +7 more
doaj +1 more source
Inhibitory effects of fluoxetine on the secretion of inflammatory mediators and JAK/STAT3 and JNK/TLR4 gene expression [PDF]
, 2022 Hoda Mojiri-Forushani +3 more
openalex +1 more source
Learning signals of adverse drug-drug interactions from the unstructured text of electronic health records. [PDF]
, 2013 Drug-drug interactions (DDI) account for 30% of all adverse drug reactions, which are the fourth leading cause of death in the US. Current methods for post marketing surveillance primarily use spontaneous reporting systems for learning DDI signals and ...
Bauer-Mehren, Anna +4 more
core +5 more sources
Sentience in cephalopod molluscs: an updated assessment
Biological Reviews, EarlyView.ABSTRACT This article evaluates the evidence for sentience – the capacity to have feelings – in cephalopod molluscs: octopus, cuttlefish, squid, and nautilus. Our framework includes eight criteria, covering both whether the animal's nervous system could support sentience and whether their behaviour indicates sentience.
Alexandra K. Schnell +4 more
wiley +1 more source
Early intervention combined with targeted treatment promotes cognitive and behavioral improvements in young children with fragile x syndrome. [PDF]
, 2012 Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability due to an expansion in the full mutation range (>200 CGG repeats) of the promoter region of the FMR1 gene leading to gene silencing.
Borodyanskara, Mariya +3 more
core +3 more sources
Clinical Pharmacology &Therapeutics, EarlyView.Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi +6 more
wiley +1 more source
Suicidal Ideation Following a Single Dose of Melatonin in a Patient With Major Depressive Disorder: A Case Report [PDF]
Clin Case RepABSTRACT Melatonin is a neurohormone that primarily regulates sleep patterns and circadian rhythms by interacting with melatonin receptors MT1 and MT2. Disruptions in circadian rhythms may contribute to mood disorders; for example, individuals with major depressive disorder often have significantly lower melatonin levels compared to healthy individuals.
Badrfam R, Zandifar A.
europepmc +2 more sources
Cloning of the Neurodegeneration Gene \u3cem\u3eDrop-Dead\u3c/em\u3e and Characterization of Additional Phenotypes of its Mutation [PDF]
, 2008 Mutations in the Drosophila gene drop-dead (drd) result in early adult lethality and neurodegeneration, but the molecular identity of the drd gene and its mechanism of action are not known.
Blumenthal, Edward M.
core +1 more source
Pathological Skin Picking: Case Presentation and Review of the Literature [PDF]
, 2015 Pathological skin picking is a condition in which patients induce skin lesions through repetitive, compulsive excoriations of normal skin or skin with minor surface irregularities and they admit their role in the production of the lesions, but are unable
Benea, Vasile +5 more
core +3 more sources
Pharmacogenomics of Major Depressive Disorder in Indigenous Amazonian Populations
Clinical Pharmacology &Therapeutics, EarlyView.Major depressive disorder is a highly prevalent psychological disorder worldwide and its main treatment is the use of Selective Serotonin Reuptake Inhibitors. However, few studies have demonstrated the relationship between the presence of genetic variants in pharmacogenes and the efficacy of these drugs, especially in populations with a unique genetic ...
Kaio Evandro Cardoso Aguiar +9 more
wiley +1 more source