Results 71 to 80 of about 105,140 (274)

Fluoxetine brakes the menstrual cycle: Uncovering the unexpected effect

Industrial Psychiatry Journal
Fluoxetine is one of the most commonly used antidepressants, classified under selective serotonin reuptake inhibitors (SSRIs). It is indicated for the treatment of depression, obsessive-compulsive disorder, anxiety, and eating disorders.
Barath Ramanathan, Souganya Vijayan, Perarul Sivakumar, Arun Selvaraj   +3 more
doaj   +1 more source

Pre-clinical drug-drug interaction (DDI) of gefitinib or erlotinib with Cytochrome P450 (CYP) inhibiting drugs, fluoxetine and/or losartan

Current Research in Toxicology, 2021
Objective: To evaluate drug-drug interactions (DDIs) between gefitinib or erlotinib with fluoxetine, and/or losartan. Methods: Human pooled microsomes, supersomes, and cryopreserved human hepatocytes were used to monitor DDIs in vitro.
Thu-Lan T. Luong, Michael J. McAnulty, David L. Evers, Brian J. Reinhardt, Peter J. Weina   +4 more
doaj   +1 more source

Decreased BOLD Signal Variability in Middle‐Aged and Older Adults on the Autism Spectrum

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a lifelong neurodevelopmental disorder. Preliminary evidence suggests an increased risk for early‐onset cognitive and neurological decline in ASD. While brain development in children, adolescents, and young adults with ASD diverges from neurotypical (NT) peers, it remains unclear in older adults with ASD ...
Stephanie Pedrahita, Annika Linke, Michaela Cordova, Molly Wilkinson, Janice Hau, Gioia Toro, Kalekirstos Alemu, Jiwandeep Kohli, Ralph‐Axel Müller, Ruth Carper   +9 more
wiley   +1 more source

Yeast supplementation potentiates fluoxetine's anti-depressant effect in mice via modulation of oxido-inflammatory, CREB, and MAPK signaling pathways

Current Research in Physiology
Introduction: The therapeutic potential of yeast in the management of depression is unknown. Thus, we evaluated the modulatory effect of nutritional yeast supplementation on antidepressant activity of fluoxetine in mice models of depressive-like ...
Augustina Potokiri, Noah A. Omeiza, Abayomi M. Ajayi, Paul A. Adeleke, Abdullateef I. Alagbonsi, Ezekiel O. Iwalewa   +5 more
doaj   +1 more source

Prescribing competence: The pros and cons of different methods for assessment

British Journal of Clinical Pharmacology, EarlyView.
Evaluating a medical graduate’s competence in rational prescribing is challenging. With the aim to guide and inspire teachers, this narrative review explores different methods that can be used to assess prescribing competence. Each method has its own advantages and disadvantages, and thus a mix of different assessment methods is needed throughout the ...
David J. Brinkman, Erik M. Donker, Jelle Tichelaar, on behalf of the CP4T programme   +3 more
wiley   +1 more source

Cost-effectiveness analysis of pharmaceutical treatment options in the first-line management of major depressive disorder in Belgium [PDF]

, 2014
The objective of this study was to assess the cost effectiveness of commonly used antidepressants as first-line treatment of major depressive disorder (MDD) in Belgium.
Annemans, Lieven, Brignone, Mélanie, De Pauw, Ann, Demyttenaere, Koen, Druais, Sylvain, Gauthier, Aline   +5 more
core   +2 more sources

Learning signals of adverse drug-drug interactions from the unstructured text of electronic health records. [PDF]

, 2013
Drug-drug interactions (DDI) account for 30% of all adverse drug reactions, which are the fourth leading cause of death in the US. Current methods for post marketing surveillance primarily use spontaneous reporting systems for learning DDI signals and ...
Bauer-Mehren, Anna, Harpaz, Rave, Iyer, Srinivasan V, Lependu, Paea, Shah, Nigam H   +4 more
core   +5 more sources

5-hydroxytryptamine (5-HT) cellular sequestration during chronic exposure delays 5-HT₃ receptor resensitization due to Its subsequent release [PDF]

, 2014
The serotonergic synapse is dynamically regulated by serotonin (5-hydroxytryptamine (5-HT)) with elevated levels leading to the down-regulation of the serotonin transporter and a variety of 5-HT receptors, including the 5-HT type-3 (5-HT(3)) receptors ...
Aapro, Ahern, Amy Alexander, Andrew J. Samson, Bearcroft, Bertrand, Bertrand, Bhattacharyya, Boyd, Chanrion, Chen, Chen, Christopher Moffat, Christopher N. Connolly, Connolly, Craig, Faerber, Freeman, Galligan, Guthrie, Hagbom, Hanley, Hansen, Hothersall, Huang, Ilegems, J. Daniel Hothersall, Jiménez-Trejo, Karen A. Bollan, Kittler, Kondaurova, Lau, Lee, Linder, Liu, Liu, Lummis, McKinnon, Mercado, Minami, Mnie-Filali, Muchatuta, Niesler, Riad, Rojas, Schlag, Spiller, Stratz, Tao-Cheng, Turvill, Vikenes, Wade, Wesseldijk, Whalen, Yasuda   +54 more
core   +3 more sources

Fluoxetine-enhanced autophagy ameliorates early brain injury via inhibition of NLRP3 inflammasome activation following subrachnoid hemorrhage in rats

Journal of Neuroinflammation, 2017
The NLRP3 inflammasome is a multiprotein complex that regulates the innate immune inflammatory response by activating caspase-1 and subsequent IL-1β and IL-18.
Jianru Li, Hangzhe Xu, S. Nie, Yucong Peng, Linfeng Fan, Zhi-jiang Wang, Cheng Wu, Feng Yan, Jingyin Chen, Chi Gu, Chun Wang, Jing-sen Chen, Lin Wang, Gao Chen   +13 more
semanticscholar   +1 more source

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source