Evolution of foot-and-mouth disease virus intra-sample sequence diversity during serial transmission in bovine hosts [PDF]
, 2013 RNA virus populations within samples are highly heterogeneous, containing a large number of minority sequence variants which can potentially be transmitted to other susceptible hosts. Consequently, consensus genome sequences provide an incomplete picture
Haydon, D.T. +6 more
core +2 more sources
Foot-and-mouth disease in Tanzania from 2001 to 2006. [PDF]
, 2010 Foot-and-mouth disease (FMD) is endemic in Tanzania, with outbreaks occurring almost each year in different parts of the country. There is now a strong political desire to control animal diseases as part of national poverty alleviation strategies ...
Berkvens, D +6 more
core +1 more source
Single-domain antibodies and their formatting to combat viral infections [PDF]
, 2018 Since their discovery in the 1990s, single-domain antibodies (VHHs), also known as NanobodiesA (R), have changed the landscape of affinity reagents. The outstanding solubility, stability, and specificity of VHHs, as well as their small size, ease of ...
Ballegeer, Marlies +4 more
core +2 more sources
A Bayesian inference framework to reconstruct transmission trees using epidemiological and genetic data [PDF]
, 2012 The accurate identification of the route of transmission taken by an infectious agent through a host population is critical to understanding its epidemiology and informing measures for its control. However, reconstruction of transmission routes during an
Chadœuf, J. +5 more
core +9 more sources
The High Immunity Induced by the Virus-Like Particles of Foot-and-Mouth Disease Virus Serotype O
Frontiers in Veterinary Science, 2021 Foot-and-mouth disease (FMD), caused by FMD virus (FMDV), is a highly contagious and economically devastating viral disease of cloven-hoofed animals worldwide.
Yan Xiao +13 more
doaj +1 more source
Distinguishing low frequency mutations from RT-PCR and sequence errors in viral deep sequencing data [PDF]
, 2015 There is a high prevalence of coronary artery disease (CAD) in patients with left bundle branch block (LBBB); however there are many other causes for this electrocardiographic abnormality.
Haydon, Daniel T. +6 more
core +2 more sources
Peptides Interfering 3A Protein Dimerization Decrease FMDV Multiplication
PLOS ONE, 2015 Nonstructural protein 3A is involved in relevant functions in foot-and-mouth disease virus (FMDV) replication. FMDV 3A can form homodimers and preservation of the two hydrophobic α-helices (α1 and α2) that stabilize the dimer interface is essential for virus replication.
González Magaldi, Mónica +5 more
openaire +6 more sources
IRES-mediated translation of foot-and-mouth disease virus (FMDV) in cultured cells derived from FMDV-susceptible and -insusceptible animals [PDF]
BMC Veterinary Research, 2016 Foot-and-mouth disease virus (FMDV) possess a positive sense, single stranded RNA genome. Internal ribosomal entry site (IRES) element exists within its 5' untranslated region (5'UTR) of the viral RNA. Translation of the viral RNA is initiated by internal entry of the 40S ribosome within the IRES element. This process is facilitated by cellular factors
Kanda, Takehiro +2 more
openaire +2 more sources
Vaccines, 2023 The construction of a full-length infectious clone, essential for molecular virological study and vaccine development, is quite a challenge for viruses with long genomes or possessing complex nucleotide sequence structures.
Ploypailin Semkum +5 more
doaj +1 more source
Complete genome sequences of three African foot-and-mouth disease viruses from clinical samples isolated in 2009 and 2010 [PDF]
, 2016 <p>The complete genome sequences of three foot-and-mouth disease viruses (one virus of each serotype SAT1, SAT2 and O) were directly sequenced from RNA extracted from clinical bovine samples, demonstrating the feasibility of full-genome sequencing ...
De Clercq, Kris +8 more
core +1 more source