Results 31 to 40 of about 7,938 (206)

The Carrier Conundrum; A Review of Recent Advances and Persistent Gaps Regarding the Carrier State of Foot-and-Mouth Disease Virus

Pathogens, 2020
The existence of a prolonged, subclinical phase of foot-and-mouth disease virus (FMDV) infection in cattle was first recognized in the 1950s. Since then, the FMDV carrier state has been a subject of controversy amongst scientists and policymakers.
Carolina Stenfeldt, Jonathan Arzt
doaj   +1 more source

Heterogeneity and Recombination of Foot-and-Mouth Disease Virus during Multi-Strain Coinfection of Cattle

mSphere, 2023
Superinfection of cattle persistently infected with foot-and-mouth disease virus (FMDV), with a heterologous FMDV strain has been shown to generate novel recombinant viruses.
Carolina Stenfeldt, Ian Fish, Haillie C. Meek, Jonathan Arzt   +3 more
doaj   +1 more source

Transient Expression of Coat Protein of Foot and Mouth Disease Virus (FMDV) in Alfalfa (Medicago sativa) by Agroinfiltration [PDF]

Journal of Cell and Molecular Research, 2016
An Agrobacterium-mediated transient gene expression assay was carried out in alfalfa (Medicago sativa) leaves for expression of a chimeric gene encoding a part of capsid protein of Foot and Mouth Disease virus called VP1.
Maziar Habibi-Pirkoohi, Saeid Malekzadeh-Shafaroudi, Hasan Marashi, Saeid Zibaee, Afsaneh Mohkami, Saba NejatizaXeh   +5 more
doaj   +1 more source

Induction of protective immune response against both PPRV and FMDV by a novel recombinant PPRV expressing FMDV VP1 [PDF]

Veterinary Research, 2014
AbstractPeste des petits ruminants (PPR) and foot-and-mouth disease (FMD) are both highly contagious diseases of small domestic and wild ruminants caused by the PPR virus (PPRV) and the FMD virus (FMDV). In this study, a recombinant PPRV expressing the FMDV VP1 gene (rPPRV/VP1) was generated and FMDV VP1 expression did not impair replication of the ...
Chunsheng Yin, Weiye Chen, Qianqian Hu, Zhiyuan Wen, Xijun Wang, Jinying Ge, Qianqian Yin, Zhi Hai-bing, Chun Xia, Zhigao Bu   +9 more
openaire   +2 more sources

Antiviral Activity Of Adamantane-Pyrazole Derivatives Against Foot And Mouth Disease Virus Infection In Vivo And In Vitro With Molecular Docking Study

Journal of Applied Veterinary Sciences, 2020
Foot-and-mouth disease (FMD) vaccine does not afford early effective protection until adaptive immune protection caused by the vaccination occurs. Therefore, an alternative prophylactic application of antiviral agents for inhibition of the FMD virus is ...
Mohammed M. S. Wassel, Wael M. Gamal El-Din , Ahmed Ragab, Gameel A. M. Elhag Ali, Yousry A. Ammar   +4 more
doaj   +1 more source

Foot-and-mouth disease virus localisation on follicular dendritic cells and sustained induction of neutralising antibodies is dependent on binding to complement receptors (CR2/CR1).

PLoS Pathogens, 2022
Previous studies have shown after the resolution of acute infection and viraemia, foot-and-mouth disease virus (FMDV) capsid proteins and/or genome are localised in the light zone of germinal centres of lymphoid tissue in cattle and African buffalo.
Lucy Gordon, Neil Mabbott, Joanna Wells, Liudmila Kulik, Nick Juleff, Bryan Charleston, Eva Perez-Martin   +6 more
doaj   +1 more source

Virus-like particles of recombinant PCV2b carrying FMDV-VP1 epitopes induce both anti-PCV and anti-FMDV antibody responses [PDF]

Applied Microbiology and Biotechnology, 2018
Mixed infection of porcine circovirus type 2 (PCV2) and foot-and-mouth disease virus (FMDV) is devastating to swine populations. To develop an effective vaccine that can protect the pigs from the infection of PCV2 and FMDV, we used the neutralizing B cell epitope region (aa 135-160) of FMDV to replace the regions aa 123-151 and aa 169-194 of the PCV2b ...
Xin, Li, Xiuping, Meng, Shengnan, Wang, Zhiqin, Li, Lei, Yang, Liqun, Tu, Wenzhen, Diao, Cheng, Yu, Yongli, Yu, Chaoying, Yan, Liying, Wang   +10 more
openaire   +2 more sources

Phospholipase PLA2G16 Accelerates the Host Interferon Signaling Pathway Response to FMDV [PDF]

Viruses
PLA2G16 is a member of the phospholipase A2 family that catalyzes the generation of lysophosphatidic acids (LPAs) and free fatty acids (FFAs) from phosphatidic acid. Previously, PLA2G16 was found to be a host factor for picornaviruses. Here, we discovered that the Foot-and-Mouth Disease Virus (FMDV) infection led to an elevation in PLA2G16 ...
Bingjie Sun, Xiaodong Qin, Taoqing Zhang, Sujie Dong, Yinbo Ye, Changying Wang, Yan Zhang, Rongzeng Hao, Yi Ru, Hong Tian, Haixue Zheng   +10 more
openalex   +3 more sources

DDX56 cooperates with FMDV 3A to enhance FMDV replication by inhibiting the phosphorylation of IRF3

Cellular Signalling, 2019
The components of foot-and-mouth disease virus (FMDV) interact with host cellular proteins to promote self-replication and evade the host immune response. Previous studies have shown that FMDV 3A, 2C and 2B proteins interact with host cellular proteins involved in FMDV replication.
Shao-zu Fu, Wen-ping Yang, Yi Ru, Ke-shan Zhang, Yong Wang, Xiang-tao Liu, Dan Li, Hai-xue Zheng   +7 more
openaire   +2 more sources

FMDV replicons encoding green fluorescent protein are replication competent [PDF]

Journal of Virological Methods, 2014
The study of replication of viruses that require high bio-secure facilities can be accomplished with less stringent containment using non-infectious 'replicon' systems. The FMDV replicon system (pT7rep) reported by Mclnerney et al. (2000) was modified by the replacement of sequences encoding chloramphenicol acetyl-transferase (CAT) with those encoding ...
Tulloch, Fiona, Pathania, Uday, Luke, Garry A., Nicholson, John, Stonehouse, Nicola J., Rowlands, David J., Jackson, Terry, Tuthill, Toby, Haas, Juergen, Lamond, Angus I., Ryan, Martin D.   +10 more
openaire   +6 more sources