FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons [PDF]
eLife, 2021 Neurons rely on translation of synaptic mRNAs in order to generate activity-dependent changes in plasticity. Here, we develop a strategy combining compartment-specific crosslinking immunoprecipitation (CLIP) and translating ribosome affinity purification
Caryn R Hale +8 more
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FMRP regulates GABAA receptor channel activity to control signal integration in hippocampal granule cells [PDF]
Cell Reports, 2022 Summary: Fragile X syndrome, the most common inherited form of intellectual disability, is caused by loss of fragile X mental retardation protein (FMRP).
Pan-Yue Deng +3 more
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The Identification of Nuclear FMRP Isoform Iso6 Partners
Cells, 2023 A deficiency of FMRP, a canonical RNA-binding protein, causes the development of Fragile X Syndrome (FXS), which is characterised by multiple phenotypes, including neurodevelopmental disorders, intellectual disability, and autism.
Nassim Ledoux +6 more
doaj +3 more sources
Neurobiology of Disease, 2023 Fragile X Messenger Ribonucleoprotein (FMRP) is necessary for experience-dependent, developmental synapse elimination and the loss of this process may underlie the excess dendritic spines and hyperconnectivity of cortical neurons in Fragile X Syndrome, a
Julia R. Wilkerson +8 more
doaj +1 more source
The research progress on the role of FMRP in the pathogenesis of tumors
Pifu-xingbing zhenliaoxue zazhi, 2023 Fragile X mental retardation protein (FMRP) is a selective RNA-binding protein that is highly expressed in neurons and influences cytoskeletal remodeling, cell-cell signal transduction and interactions.
Huizhi YANG +5 more
doaj +1 more source
Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways [PDF]
, 2016 Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective treatment available. An increasing number of genetic causes of ALS are being identified, but how these genetic defects lead to motor neuron degeneration and ...
Anink, Jasper J. +17 more
core +9 more sources
A novel function for fragile X mental retardation protein in translational activation. [PDF]
PLoS Biology, 2009 Fragile X syndrome, the most frequent form of inherited mental retardation, is due to the absence of Fragile X Mental Retardation Protein (FMRP), an RNA-binding protein involved in several steps of RNA metabolism.
Elias G Bechara +10 more
doaj +1 more source
Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin. [PDF]
PLoS ONE, 2014 Fragile X mental Retardation Protein (FMRP) is a well-known regulator of local translation of its mRNA targets in neurons. However, despite its ubiquitous expression, the role of FMRP remains ill-defined in other cell types. In this study we investigated
Mohamed S Taha +7 more
doaj +1 more source
Association between IQ and FMR1 protein (FMRP) across the spectrum of CGG repeat expansions.
PLoS ONE, 2019 Fragile X syndrome, the leading heritable form of intellectual disability, is caused by hypermethylation and transcriptional silencing of large (CGG) repeat expansions (> 200 repeats) in the 5' untranslated region of the fragile X mental retardation 1 ...
Kyoungmi Kim +8 more
doaj +1 more source
FMRP and MOV10 regulate Dicer1 expression and dendrite development.
PLoS ONE, 2021 Fragile X syndrome results from the loss of expression of the Fragile X Mental Retardation Protein (FMRP). FMRP and RNA helicase Moloney Leukemia virus 10 (MOV10) are important Argonaute (AGO) cofactors for miRNA-mediated translation regulation.
Monica C Lannom +4 more
doaj +1 more source