Results 101 to 110 of about 22,945 (246)

Premature recruitment of oocyte pool and increased mTOR activity in Fmr1 knockout mice and reversal of phenotype with rapamycin. [PDF]

, 2018
While mutations in the fragile X mental retardation-1 (FMR1) gene are associated with varying reproductive outcomes in females, the effects of a complete lack of FMR1 expression are not known.
Ascano, M, Mok-Lin, E, Rosenwaks, Z, Serganov, A, Tuschl, T, Williams, Z   +5 more
core   +2 more sources

Novel Wide‐Spectrum Virucidal Lipid Nanoparticles

Small, Volume 22, Issue 7, 2 February 2026.
POSTAN is a novel broad‐spectrum antiviral nanoparticle that combines safety with potent virucidal activity. Composed of biocompatible lipids, it mimics heparan sulfate proteoglycans and lipid rafts exploited by viruses, thereby dismantling viral envelopes and blocking replication.
Yugo Araújo Martins, Louise Bondeelle, Arnaud Charles‐Antoine Zwygart, Thais Melquiades de Lima, Juliano de Paula Souza, Han Kang Tee, Fernando Chahud, Eurico de Arruda Neto, Francesco Stellacci, Renata Fonseca Vianna Lopez, Caroline Tapparel   +10 more
wiley   +1 more source

The Different FMRP Isoforms Bind with High Affinity to the G-Quadruplex formed by the FMRP mRNA [PDF]

Biophysical Journal, 2013
Fragile X syndrome, the most common form of inherited mental retardation in humans, affects about 1 in 3000 males and 1 in 5000 females. It is caused by the loss of expression of the fragile X mental retardation protein (FMRP) due to a CGG trinucleotide repeat expansion in the 5'-untranslated region (UTR) of the fragile x mental retardation-1 (fmr1 ...
Blice-Baum, Anna, Mihailescu, Rita
openaire   +1 more source

Hair root FMRP expression for screening of fragile X full mutation females [PDF]

Universa Medicina, 2011
The fragile X syndrome is the most common form of inherited mental retardation in humans, caused by an expansion of the cytosine-guanine-guanine (CGG) repeat in the fragile X mental retardation 1 (FMR1) gene located on the X chromosome.
Lantip Rujito, Dwi Kustiani, Lies Anne Severijnen, Peter Hanzon, Sultana MH Faradz, Rob Willemsen   +5 more
doaj  

Altered Auditory Maturation in Fragile X Syndrome and Its Involvement in Audiogenic Seizure Susceptibility

Autism Research, Volume 19, Issue 1, January 2026.
ABSTRACT Auditory hypersensitivity is a prominent symptom in Fragile X syndrome (FXS), the most prevalent monogenic cause of autism and intellectual disability. FXS arises through the loss of the protein encoded by the FMR1 (Fragile X Messenger Ribonucleoprotein 1) gene, FMRP, required for normal neural circuit excitability.
Dorit Möhrle, Demi Ma, Wenyue Xue, Jun Yan, Ning Cheng   +4 more
wiley   +1 more source

Phosphorylation influences the translation state of FMRP-associated polyribosomes [PDF]

Human Molecular Genetics, 2003
Fragile X mental retardation protein, FMRP, is absent in patients with fragile X syndrome, a common form of mental retardation. FMRP is a nucleocytoplasmic RNA binding protein that is primarily associated with polyribosomes. FMRP is believed to be a translational repressor and may regulate the translation of certain mRNAs at the base of dendritic ...
Stephanie, Ceman, William T, O'Donnell, Matt, Reed, Stephana, Patton, Jan, Pohl, Stephen T, Warren   +5 more
openaire   +2 more sources

Paradoxical roles of the neutrophil in sepsis: protective and deleterious

Frontiers in Immunology, 2016
Sepsis, an overwhelming inflammatory response syndrome secondary to infection, is one of the costliest and deadliest medical conditions worldwide.
Fabiane eSônego, Fabiane eSônego, Fernanda Vargas e Silva Castanheira, Raphael Gomes Ferreira, Alexandre eKanashiro, Caio Abner Vitorino Golçalves Leite, Daniele Carvalho Nascimento, David Fernando Colón, Vanessa Fátima Borges, José C Alves-Filho, Fernando Queiróz Cunha   +10 more
doaj   +1 more source

Modulators of Diacylglycerol Kinase Activity: A Review of Advances and Challenges

Medicinal Research Reviews, Volume 46, Issue 1, Page 149-175, January 2026.
ABSTRACT Catalyzing the conversion of diacylglycerol (DAG) in phosphatidic acid (PA), diacylglycerol kinases (DGKs) play a pivotal role in all the physiological processes modulated by these two bioactive lipids, such as lipid metabolism and immune regulation.
Luisa Racca, Gianluca Baldanzi, Alberto Massarotti   +2 more
wiley   +1 more source

FMRP Mediates mGluR5-Dependent Translation of Amyloid Precursor Protein

PLoS Biology, 2007
Amyloid precursor protein (APP) facilitates synapse formation in the developing brain, while beta-amyloid (Abeta) accumulation, which is associated with Alzheimer disease, results in synaptic loss and impaired neurotransmission. Fragile X mental retardation protein (FMRP) is a cytoplasmic mRNA binding protein whose expression is lost in fragile X ...
Cara J Westmark, James S Malter
openaire   +4 more sources

Conformational-Dependent and Independent RNA Binding to the Fragile X Mental Retardation Protein

Journal of Nucleic Acids, 2011
The interaction between the fragile X mental retardation protein (FMRP) and BC1 RNA has been the subject of controversy. We probed the parameters of RNA binding to FMRP in several ways. Nondenaturing agarose gel analysis showed that BC1 RNA transcripts
Xin Yan, Robert B. Denman
doaj   +1 more source