Results 11 to 20 of about 21,903 (205)

Cellular stress-induced up-regulation of FMRP promotes cell survival by modulating PI3K-Akt phosphorylation cascades [PDF]

Journal of Biomedical Science, 2011
Background Fragile X syndrome (FXS), the most commonly inherited mental retardation and single gene cause of autistic spectrum disorder, occurs when the Fmr1 gene is mutated.
Wells David, Choi Ji, Yang Sung-Il, Seo Jung, Jeon Se, Shin Chan, Ko Kwang   +6 more
doaj   +4 more sources

The Identification of Nuclear FMRP Isoform Iso6 Partners

Cells, 2023
A deficiency of FMRP, a canonical RNA-binding protein, causes the development of Fragile X Syndrome (FXS), which is characterised by multiple phenotypes, including neurodevelopmental disorders, intellectual disability, and autism.
Nassim Ledoux, Emeline I. J. Lelong, Alexandre Simard, Samer Hussein, Pauline Adjibade, Jean-Philippe Lambert, Rachid Mazroui   +6 more
doaj   +3 more sources

THE FMRP REGULON: FROM TARGETS TO DISEASE CONVERGENCE [PDF]

Frontiers in Neuroscience, 2013
The fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates mRNA metabolism. FMRP has been largely studied in the brain, where the absence of this protein leads to fragile X syndrome, the most frequent form of inherited ...
Esperanza eFernandez, Nicholas eRajan, Claudia eBagni, Claudia eBagni   +3 more
doaj   +4 more sources

Intercepting IRE1 kinase‐FMRP signaling prevents atherosclerosis progression [PDF]

EMBO Molecular Medicine, 2022
Fragile X Mental Retardation protein (FMRP), widely known for its role in hereditary intellectual disability, is an RNA‐binding protein (RBP) that controls translation of select mRNAs.
Zehra Yildirim, Sabyasachi Baboo, Syed M Hamid, Asli E Dogan, Ozlem Tufanli, Sabrina Robichaud, Christina Emerton, Jolene K Diedrich, Hasan Vatandaslar, Fotis Nikolos, Yanghong Gu, Takao Iwawaki, Elizabeth Tarling, Mireille Ouimet, David L Nelson, John R Yates, Peter Walter, Ebru Erbay   +17 more
doaj   +7 more sources

FMRP modulates the Wnt signalling pathway in glioblastoma

Cell Death and Disease, 2022
Converging evidence indicates that the Fragile X Messenger Ribonucleoprotein (FMRP), which absent or mutated in Fragile X Syndrome (FXS), plays a role in many types of cancers.
Giorgia Pedini, Mariachiara Buccarelli, Fabrizio Bianchi, Laura Pacini, Giulia Cencelli, Quintino Giorgio D’Alessandris, Maurizio Martini, Stefano Giannetti, Franceschina Sasso, Valentina Melocchi, Maria Giulia Farace, Tilmann Achsel, Luigi M. Larocca, Lucia Ricci-Vitiani, Roberto Pallini, Claudia Bagni   +15 more
doaj   +9 more sources

FMRP phosphorylation and interactions with Cdh1 regulate association with dendritic RNA granules and MEF2-triggered synapse elimination

Neurobiology of Disease, 2023
Fragile X Messenger Ribonucleoprotein (FMRP) is necessary for experience-dependent, developmental synapse elimination and the loss of this process may underlie the excess dendritic spines and hyperconnectivity of cortical neurons in Fragile X Syndrome, a
Julia R. Wilkerson, Marius F. Ifrim, Arielle N. Valdez-Sinon, Patricia Hahn, Jacob E. Bowles, Gemma Molinaro, Aleksandra Janusz-Kaminska, Gary J. Bassell, Kimberly M. Huber   +8 more
doaj   +1 more source

Altered inflammatory response in FMRP-deficient microglia [PDF]

iScience, 2021
Fragile X syndrome (FXS) is an inherited intellectual disability with a high risk for comorbid autism spectrum disorders. Since FXS is a genetic disease, patients are more susceptible to environmental factors aggravating symptomatology. However, this confounding interaction between FXS environmental and genetic risk factors is under-investigated. Here,
Jennifer M. Parrott, Thomas Oster, Hye Young Lee   +2 more
openaire   +3 more sources

FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons

eLife, 2021
Neurons rely on translation of synaptic mRNAs in order to generate activity-dependent changes in plasticity. Here, we develop a strategy combining compartment-specific crosslinking immunoprecipitation (CLIP) and translating ribosome affinity purification
Caryn R Hale, Kirsty Sawicka, Kevin Mora, John J Fak, Jin Joo Kang, Paula Cutrim, Katarzyna Cialowicz, Thomas S Carroll, Robert B Darnell   +8 more
doaj   +1 more source

FMRP regulates GABAA receptor channel activity to control signal integration in hippocampal granule cells

Cell Reports, 2022
Summary: Fragile X syndrome, the most common inherited form of intellectual disability, is caused by loss of fragile X mental retardation protein (FMRP).
Pan-Yue Deng, Ajeet Kumar, Valeria Cavalli, Vitaly A. Klyachko   +3 more
doaj   +1 more source

SnapShot: FMRP Interacting Proteins [PDF]

Cell, 2014
The Fragile X syndrome, caused by the absence or mutation of fragile X mental retardation protein, FMRP, is a the common component of inherited intellectual disability and autism. This SnapShot surveys the protein interaction partners of FMRP, focusing on the cellular pathways in which they are involved.
Pasciuto, E, BAGNI, CLAUDIA
openaire   +3 more sources