FMRP Depletion Reprograms an Immunosuppressive Microenvironment [PDF]
Cancer Discovery, 2022 Abstract Cancer cell expression of the RNA binding protein FMRP promotes the suppression of CD8+ T cells.
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Ultrastructural analysis of the functional domains in FMRP using primary hippocampal mouse neurons
Neurobiology of Disease, 2009 Fragile X syndrome is caused by lack of the protein FMRP. FMRP mediates mRNA binding, dendritic mRNA transport and translational control at spines.
Josien Levenga +7 more
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eLife, 2020 The sorting of RNA molecules to subcellular locations facilitates the activity of spatially restricted processes. We have analyzed subcellular transcriptomes of FMRP-null mouse neuronal cells to identify transcripts that depend on FMRP for efficient ...
Raeann Goering +7 more
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THE FMRP REGULON: FROM TARGETS TO DISEASE CONVERGENCE [PDF]
Frontiers in Neuroscience, 2013 The fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates mRNA metabolism. FMRP has been largely studied in the brain, where the absence of this protein leads to fragile X syndrome, the most frequent form of inherited ...
Esperanza eFernandez +3 more
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Intercepting IRE1 kinase‐FMRP signaling prevents atherosclerosis progression [PDF]
EMBO Molecular Medicine, 2022 Fragile X Mental Retardation protein (FMRP), widely known for its role in hereditary intellectual disability, is an RNA‐binding protein (RBP) that controls translation of select mRNAs.
Zehra Yildirim +17 more
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FMRP modulates the Wnt signalling pathway in glioblastoma
Cell Death and Disease, 2022 Converging evidence indicates that the Fragile X Messenger Ribonucleoprotein (FMRP), which absent or mutated in Fragile X Syndrome (FXS), plays a role in many types of cancers.
Giorgia Pedini +15 more
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FMRP Associates with Cytoplasmic Granules at the Onset of Meiosis in the Human Oocyte.
PLoS ONE, 2016 Germ cell development and primordial follicle formation during fetal life is critical in establishing the pool of oocytes that subsequently determines the reproductive lifespan of women.
Roseanne Rosario +6 more
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Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures [PDF]
Neurobiology of Disease, 2013 Outside of Fragile X syndrome (FXS), the role of Fragile-X Mental Retardation Protein (FMRP) in mediating neuropsychological abnormalities is not clear.
Paul B. Bernard +5 more
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Genetic Reduction of the Translational Repressors FMRP and 4E-BP2 Preserves Memory in Mouse Models of Alzheimer's Disease. [PDF]
Aging CellGenetic reduction of the translational repressors FMRP or 4E‐BP2 prevents amyloid‐β oligomer–induced suppression of hippocampal protein synthesis and memory loss in mice. Targeting translational control preserves cognitive function in Alzheimer's models, revealing mRNA translation as a promising therapeutic axis for memory preservation.
Ribeiro FC +11 more
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Altered inflammatory response in FMRP-deficient microglia [PDF]
iScience, 2021 Fragile X syndrome (FXS) is an inherited intellectual disability with a high risk for comorbid autism spectrum disorders. Since FXS is a genetic disease, patients are more susceptible to environmental factors aggravating symptomatology. However, this confounding interaction between FXS environmental and genetic risk factors is under-investigated. Here,
Jennifer M. Parrott +2 more
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