Results 41 to 50 of about 21,903 (205)

Fragile X Mental Retardation Protein Regulates Activity-Dependent Membrane Trafficking and Trans-Synaptic Signaling Mediating Synaptic Remodeling

Frontiers in Molecular Neuroscience, 2018
Fragile X syndrome (FXS) is the leading monogenic cause of autism and intellectual disability. The disease arises through loss of fragile X mental retardation protein (FMRP), which normally exhibits peak expression levels in early-use critical periods ...
James C. Sears, Kendal Broadie, Kendal Broadie, Kendal Broadie   +3 more
doaj   +1 more source

FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences

eLife, 2020
The sorting of RNA molecules to subcellular locations facilitates the activity of spatially restricted processes. We have analyzed subcellular transcriptomes of FMRP-null mouse neuronal cells to identify transcripts that depend on FMRP for efficient ...
Raeann Goering, Laura I Hudish, Bryan B Guzman, Nisha Raj, Gary J Bassell, Holger A Russ, Daniel Dominguez, J Matthew Taliaferro   +7 more
doaj   +1 more source

Quantitative nucleotide level analysis of regulation of translation in response to depolarization of cultured neural cells [PDF]

, 2017
Studies on regulation of gene expression have contributed substantially to understanding mechanisms for the long-term activity-dependent alterations in neural connectivity that are thought to mediate learning and memory.
Dalal, Jasbir S, Dougherty, Joseph D, Lake, Allison M, O\u27Brien, David R, Sapkota, Darshan, Yang, Chengran   +5 more
core   +2 more sources

FMRP Interacts with C/D Box snoRNA in the Nucleus and Regulates Ribosomal RNA Methylation

iScience, 2018
Summary: FMRP is an RNA-binding protein that is known to localize in the cytoplasm and in the nucleus. Here, we have identified an interaction of FMRP with a specific set of C/D box snoRNAs in the nucleus.
Michelle Ninochka D'Souza, Naveen Kumar Chandappa Gowda, Vishal Tiwari, Rosana Ottakandathil Babu, Praveen Anand, Sudhriti Ghosh Dastidar, Randhir Singh, Owen G. James, Bhuvaneish Selvaraj, Rakhi Pal, Arati Ramesh, Sumantra Chattarji, Siddharthan Chandran, Akash Gulyani, Dasaradhi Palakodeti, Ravi S. Muddashetty   +15 more
doaj   +1 more source

Targeting FMRP: A new window for cancer immunotherapy

MedComm, 2023
FMRP is regulated by Myc and is highly expressed in a variety of human and mouse tumor tissues.FMRP recruits Treg and M2 macrophages to form an immunosuppressive tumor microenvironment by IL3, PROS1 and exosomes.FMRP-KO up-regulates tumor cell secretion of CCL7, which directly activates and recruits CD8+ T cells.FMRP-KO recruits CCR5 and CXCR4 receptor-
Yaguang Zhang, Tong Wu, Junhong Han
openaire   +3 more sources

Genetic association of FMRP targets with psychiatric disorders [PDF]

Molecular Psychiatry, 2020
Abstract Genes encoding the mRNA targets of fragile X mental retardation protein (FMRP) are enriched for genetic association with psychiatric disorders. However, many FMRP targets possess functions that are themselves genetically associated with psychiatric disorders, including synaptic transmission and plasticity, making it unclear ...
Nicholas E. Clifton, Elliott Rees, Peter A. Holmans, Antonio F. Pardiñas, Janet C. Harwood, Arianna Di Florio, George Kirov, James T. R. Walters, Michael C. O’Donovan, Michael J. Owen, Jeremy Hall, Andrew J. Pocklington   +11 more
openaire   +3 more sources

Fragile X mental retardation protein is a Zika virus restriction factor that is antagonized by subgenomic flaviviral RNA

eLife, 2018
Subgenomic flaviviral RNA (sfRNA) accumulates during infection due to incomplete degradation of viral genomes and interacts with cellular proteins to promote infection. Here we identify host proteins that bind the Zika virus (ZIKV) sfRNA.
Ruben Soto-Acosta, Xuping Xie, Chao Shan, Coleman K Baker, Pei-Yong Shi, Shannan L Rossi, Mariano A Garcia-Blanco, Shelton Bradrick   +7 more
doaj   +1 more source

Gene therapy using human FMRP isoforms driven by the human FMR1 promoter rescues fragile X syndrome mouse deficits

Molecular Therapy: Methods & Clinical Development, 2022
Fragile X syndrome (FXS) is caused by the loss of the fragile X messenger ribonucleoprotein 1 (FMRP) encoded by the FMR1 gene. Gene therapy using adeno-associated virus (AAV) to restore FMRP expression is a promising therapeutic strategy. However, so far
Yiru Jiang, Linkun Han, Jian Meng, Zijie Wang, Yunqiang Zhou, Huilong Yuan, Hui Xu, Xian Zhang, Yingjun Zhao, Jinsheng Lu, Huaxi Xu, Chen Zhang, Yun-wu Zhang   +12 more
doaj   +1 more source

Protein synthesis at synaptic sites on dendrites [PDF]

, 2001
Studies over the past 20 years have revealed that gene expression in neurons is carried out by a distributed network of translational machinery. One component of this network is localized in dendrites, where polyribosomes and associated membranous ...
Schuman, Erin M., Steward, Oswald
core   +1 more source

A novel function for fragile X mental retardation protein in translational activation.

PLoS Biology, 2009
Fragile X syndrome, the most frequent form of inherited mental retardation, is due to the absence of Fragile X Mental Retardation Protein (FMRP), an RNA-binding protein involved in several steps of RNA metabolism.
Elias G Bechara, Marie Cecile Didiot, Mireille Melko, Laetitia Davidovic, Mounia Bensaid, Patrick Martin, Marie Castets, Philippe Pognonec, Edouard W Khandjian, Hervé Moine, Barbara Bardoni   +10 more
doaj   +1 more source