Results 51 to 60 of about 22,945 (246)

Developmentally-programmed FMRP expression in oligodendrocytes: a potential role of FMRP in regulating translation in oligodendroglia progenitors [PDF]

Human Molecular Genetics, 2003
The fragile X mental retardation protein (FMRP) is a selective RNA-binding protein whose function is implicated in regulating protein synthesis of its mRNA targets. The lack of FMRP leads to abnormal synapse development in the brain and impaired learning/memory.
Houping, Wang, Li, Ku, Donna J, Osterhout, Wen, Li, Amir, Ahmadian, Zhe, Liang, Yue, Feng   +6 more
openaire   +2 more sources

O Desenvolvimento Docente na FMRP-USP: contexto histórico

Medicina (Ribeirão Preto), 2022
O objetivo desse artigo é contextualizar historicamente as ações de desenvolvimento docente realizadas na Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP) desde sua fundação até a criação do Centro de Desenvolvimento Docente para o Ensino (CDDE) para as Profissões da Saúde, que foi a primeira unidade formal da instituição
Karine Angélica Cintra Cintra, Marcos de Carvalho Borges, Maria Paula Panúncio-Pinto, Maria de Lourdes Veronese Rodrigues, Luis Ernesto de Almeida Troncon, Valdes Roberto Bollela   +5 more
openaire   +2 more sources

A Genotype-Phenotype Study of High-Resolution FMR1 Nucleic Acid and Protein Analyses in Fragile X Patients with Neurobehavioral Assessments

Brain Sciences, 2020
Fragile X syndrome (FXS) is caused by silencing of the FMR1 gene, which encodes a protein with a critical role in synaptic plasticity. The molecular abnormality underlying FMR1 silencing, CGG repeat expansion, is well characterized; however, delineation ...
Dejan B. Budimirovic, Annette Schlageter, Stela Filipovic-Sadic, Dragana D. Protic, Eran Bram, E. Mark Mahone, Kimberly Nicholson, Kristen Culp, Kamyab Javanmardi, Jon Kemppainen, Andrew Hadd, Kevin Sharp, Tatyana Adayev, Giuseppe LaFauci, Carl Dobkin, Lili Zhou, William Ted Brown, Elizabeth Berry-Kravis, Walter E. Kaufmann, Gary J. Latham   +19 more
doaj   +1 more source

Protein synthesis at synaptic sites on dendrites [PDF]

, 2001
Studies over the past 20 years have revealed that gene expression in neurons is carried out by a distributed network of translational machinery. One component of this network is localized in dendrites, where polyribosomes and associated membranous ...
Schuman, Erin M., Steward, Oswald
core   +1 more source

Epitranscriptome and FMRP Regulated mRNA Translation [PDF]

Epigenomes, 2017
An important regulatory mechanism affecting mRNA translation involves various covalent modifications of RNA, which establish distinct epitranscriptomic signatures that actively influence various physiological processes. Dendritic translation in mammalian neurons is a potent target for RNA modification-based regulation.
Pritha Majumder, Biswanath Chatterjee, C.-K. James Shen   +2 more
openaire   +2 more sources

The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation

EMBO Molecular Medicine, 2013
The role of the fragile X mental retardation protein (FMRP) is well established in brain, where its absence leads to the fragile X syndrome (FXS). FMRP is almost ubiquitously expressed, suggesting that, in addition to its effects in brain, it may have ...
Rossella Lucá, Michele Averna, Francesca Zalfa, Manuela Vecchi, Fabrizio Bianchi, Giorgio La Fata, Franca Del Nonno, Roberta Nardacci, Marco Bianchi, Paolo Nuciforo, Sebastian Munck, Paola Parrella, Rute Moura, Emanuela Signori, Robert Alston, Anna Kuchnio, Maria Giulia Farace, Vito Michele Fazio, Mauro Piacentini, Bart De Strooper, Tilmann Achsel, Giovanni Neri, Patrick Neven, D. Gareth Evans, Peter Carmeliet, Massimiliano Mazzone, Claudia Bagni   +26 more
doaj   +1 more source

Dynamic scaffolds for neuronal signaling: in silico analysis of the TANC protein family [PDF]

, 2017
The emergence of genes implicated across multiple comorbid neurologic disorders allows to identify shared underlying molecular pathways. Recently, investigation of patients with diverse neurologic disorders found TANC1 and TANC2 as possible candidate ...
Gasparini, Alessandra, Leonardi, Emanuela, Murgia, Alessandra, Tosatto, Silvio C. E.   +3 more
core   +1 more source

FMRP: a triple threat to PSD-95 [PDF]

Frontiers in Cellular Neuroscience, 2013
Autism is a spectrum of developmental disorders characterized by deficits in verbal and non-verbal communication, social awareness and interactions, and imaginative play (Caronna et al., 2008). There is a strong genetic basis for autism, which is highly comorbid with single-gene disorders including fragile X syndrome (FXS) (Wang et al., 2010). The main
openaire   +3 more sources

Cellular localization of the FMRP in rat retina [PDF]

Bioscience Reports, 2020
Abstract The fragile X mental retardation protein (FMRP) is a regulator of local translation through its mRNA targets in the neurons. Previous studies have demonstrated that FMRP may function in distinct ways during the development of different visual subcircuits.
Ping-Ping Zhang, Hui-Hui Yao, An-Hui Zha, Xing-Yue Liu, Ke-Yu Fan, Yue Xu, Hui-Yao Yuan, Lei Li, Lie-Cheng Wang   +8 more
openaire   +2 more sources

Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes. [PDF]

, 2018
Heterogeneity in early language development in autism spectrum disorder (ASD) is clinically important and may reflect neurobiologically distinct subtypes.
A Battle, A Krishnan, A Perry, A Schroeder, A Sugathan, A Venter, AJ Willsey, AM Wetherby, AR McIntosh, AR Pfenning, AT Hilliard, BS Abrahams, C Demopoulos, C Lord, CR Genovese, Cynthia Carter Barnes, DA Rossignol, DH Geschwind, DH Geschwind, DL Vargas, E Redcay, E Redcay, EA Boyle, EJ Greenblatt, Eric Courchesne, F Happé, G Dehaene-Lambertz, G Hickok, G Konopka, G Konopka, H Tager-Flusberg, HR Cremers, I Voineagu, J Cotney, JA Kosmicki, JA Miller, JC Darnell, JD Storey, JI Berman, JT Morgan, K Gotham, K Pierce, K Pierce, K Pierce, Karen Pierce, L Hippolyte, Linda Lopez, Lisa Eyler, LT Eyler, M Chikina, M Lek, MC Lai, MC Oldham, MCN Marchetto, ME Ritchie, Michael V. Lombardo, MM Kjelgaard, MV Lombardo, Nathan E. Lewis, NN Parikshak, NN Parikshak, NR Wray, P Du, P Howlin, P Langfelder, P Langfelder, P Szatmari, R Bernier, RC Gentleman, Richard A. I. Bethlehem, RJ Kelleher III, S Kapur, S Rubeis De, S Sandin, SJ Sanders, T Pramparo, T Pramparo, T Yarkoni, Tiziano Pramparo, Vahid Gazestani, Varun Warrier, X Liu, X Nuttle   +82 more
core   +1 more source