Results 71 to 80 of about 21,903 (205)

Voltage-independent SK-channel dysfunction causes neuronal hyperexcitability in the hippocampus of Fmr1 knock-out mice [PDF]

, 2019
Neuronal hyperexcitability is one of the major characteristics of fragile X syndrome (FXS), yet the molecular mechanisms of this critical dysfunction remain poorly understood. Here we report a major role of voltage-independent potassium (
Carlin, Dan, Cavalli, Valeria, Deng, Pan-Yue, Klyachko, Vitaly A, Myrick, Leila K, Oh, Young Mi, Warren, Stephen T   +6 more
core   +1 more source

Controlled trial of lovastatin combined with an open-label treatment of a parent-implemented language intervention in youth with fragile X syndrome. [PDF]

, 2020
BackgroundThe purpose of this study was to conduct a 20-week controlled trial of lovastatin (10 to 40 mg/day) in youth with fragile X syndrome (FXS) ages 10 to 17 years, combined with an open-label treatment of a parent-implemented language intervention (
Abbeduto, Leonard, Banasik, Amy, Bullard, Lauren, Hagerman, Randi, Kim, Kyoungmi, McDuffie, Andrea, Nguyen, Vivian, Potter, Laura A, Potter, Sarah Nelson, Tassone, Flora, Thurman, Angela John   +10 more
core  

Dynamic scaffolds for neuronal signaling: in silico analysis of the TANC protein family [PDF]

, 2017
The emergence of genes implicated across multiple comorbid neurologic disorders allows to identify shared underlying molecular pathways. Recently, investigation of patients with diverse neurologic disorders found TANC1 and TANC2 as possible candidate ...
Gasparini, Alessandra, Leonardi, Emanuela, Murgia, Alessandra, Tosatto, Silvio C. E.   +3 more
core   +1 more source

Dietary and biomarker‐guided strategies as supportive measures in the fragile X syndrome

Food Biomacromolecules, EarlyView.
Abstract The fragile X syndrome (FXS) is an inherited neurodevelopmental disorder that primarily affects males, often resulting in an IQ below 55, while about two‐thirds of females also experience intellectual disability. Physical features may include an elongated face, prominent ears, finger joint laxity, and enlarged testes in males.
Jailan E. El Halawani, Reem R. AlOlaby
wiley   +1 more source

AIP1 is a novel Agenet/Tudor domain protein from Arabidopsis that interacts with regulators of DNA replication, transcription and chromatin remodeling [PDF]

, 2015
Background: DNA replication and transcription are dynamic processes regulating plant development that are dependent on the chromatin accessibility. Proteins belonging to the Agenet/Tudor domain family are known as histone modification "readers" and ...
Barroso-Neto, Ito Liberato, Brasil, Juliana Nogueira, Cabral, Luiz Mors, Eloy, Nubia Barbosa, Ferreira, Paulo CG, Gonzalez Sanchez, Nathalie, Hemerly, Adriana S, Inzé, Dirk, Perdigão Grangeiro, Leticia P, Primo, Luiza MF   +9 more
core   +3 more sources

Generative Artificial Intelligence–Driven Clinical Case Simulation in Temporomandibular Disorder Education: ChatGPT Versus Real Patients

Journal of Dental Education, EarlyView.
ABSTRACT Background Temporomandibular disorders (TMDs) and orofacial pain (OFP) demand advanced diagnostic and clinical reasoning skills in dental education. Traditional simulations with real patients face limitations in availability and standardization.
Paula Rodrigues‐Pereira, Maria Amália Pereira Dias‐Calças, Alex Moreira Mélo, Melissa de Oliveira Melchior, Lucas Gaspar Ribeiro, Antônio Pazin‐Filho, Jardel Francisco Mazzi‐Chaves, Laís Valencise Magri   +7 more
wiley   +1 more source

Evaluating the Air Respiratory Capacity of Awaous (Chonophorus) tajasica (Gobiiformes: Oxudercidae): A Morpho‐Functional Study

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
We demonstrated that Awaous tajasica performs facultative air breathing under experimental conditions of dissolved oxygen limitation, retaining air bubbles in the buccal cavity during gill ventilation. Morpho‐functional evidence indicates the use of atmospheric oxygen as a respiratory support under conditions of low water oxygenation.
João Pedro Trevisan, Diego Venturelli, Wilfried Klein, André Luis da Cruz   +3 more
wiley   +1 more source

FMRP protects breast cancer cells from ferroptosis by promoting SLC7A11 alternative splicing through interacting with hnRNPM

Redox Biology
Ferroptosis is a unique modality of regulated cell death that is driven by iron-dependent phospholipid peroxidation. N6-methyladenosine (m6A) RNA modification participates in varieties of cellular processes. However, it remains elusive whether m6A reader
Nan Wang, Bin Shi, Lu Ding, Xu Zhang, Xiaolan Ma, Songlin Guo, Xia Qiao, Libin Wang, Duan Ma, Jia Cao   +9 more
doaj   +1 more source

Characterization of Fragile X Mental Retardation Protein granules formation and dynamics in Drosophila

Biology Open, 2012
Summary FMRP is an evolutionarily conserved protein that is highly expressed in neurons and its deficiency causes fragile X mental retardation syndrome.
Cristina Gareau, David Martel, Laetitia Coudert, Samia Mellaoui, Rachid Mazroui   +4 more
doaj   +1 more source

Clinical and molecular correlates in fragile X premutation females. [PDF]

, 2017
The prevalence of the fragile X premutation (55-200 CGG repeats) among the general population is relatively high, but there remains a lack of clear understanding of the links between molecular biomarkers and clinical outcomes.
AlOlaby, Reem R, Chutabhakdikul, Nuanchan, Durbin-Johnson, Blythe, Espinal, Glenda M, Hagerman, Paul J, Hagerman, Randi J, Hessl, David, Jiraanont, Poonnada, Rivera, Susan M, Schneider, Andrea, Silva, Marisol, Sweha, Stefan R, Tang, Hiu-Tung, Tassone, Flora   +13 more
core   +2 more sources