Results 81 to 90 of about 21,903 (205)

Diagnostic Accuracy of Cough Frequency Monitors: A Systematic Review and Meta‐Analysis

Respirology, EarlyView.
ABSTRACT Background and Objective International guidelines emphasise the importance of objective cough assessment for evaluating therapeutic efficacy. Cough negatively impacts quality of life and generates high costs for healthcare systems. However, the accuracy of cough frequency monitors remains unclear.
Ana Lara Castro Rodrigues, Larisse Sousa Reis Passafaro, Daniele Oliveira dos Santos, Marcos Gontijo da Silva, Noé Mitterhofer Eiterer Ponce de Leon da Costa, Janne Marques Silveira, Arietta Spinou, Ada Clarice Gastaldi   +7 more
wiley   +1 more source

The malleable brain: plasticity of neural circuits and behavior: A review from students to students [PDF]

, 2017
One of the most intriguing features of the brain is its ability to be malleable, allowing it to adapt continually to changes in the environment. Specific neuronal activity patterns drive long-lasting increases or decreases in the strength of synaptic ...
Adeniyi, Philip A., Ali, Nilufar, Amini, Elham, Blumrich, Eva Maria, Datusalia, Ashok K., Fontanet, Paula, García Romero, Ezra Michelet, Ghosh, Shampa, Golpich, Mojtaba, Hegemann, Regina U., Jain, Vishal, Jamwal, Sumit, Joshi, Pooja, Kushwah, Neetu, Lepeta, Katarzyna, Loke, Hannah, Lourenco, Mychael V., Nawrotek, Katarzyna, Paid, Ramesh K., Pastor, Verónica, Piermartiri, Tetsade, Rotermund, Carola, Saini, Vedangana, Salamian, Ahmad, Schaefer, Natascha, Shahidzadeh, Sheila M., Sharma, Mahima, Sharma, Sorabh, Sinha, Jitendra K., Suárez Pozos, Edna, Turner, Anthony J., Vafadari, Benham, Wilson, Yvette   +32 more
core   +2 more sources

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Novel FMRP interaction networks linked to cellular stress

The FEBS Journal, 2020
Silencing of the fragile X mental retardation 1 (FMR1) gene and consequently lack of synthesis of FMR protein (FMRP) are associated with fragile X syndrome, which is one of the most prevalent inherited intellectual disabilities, with additional roles in increased viral infection, liver disease, and reduced cancer risk.
Mohamed S. Taha, Fereshteh Haghighi, Anja Stefanski, Saeideh Nakhaei‐Rad, Neda S. Kazemein Jasemi, Mohamed Aghyad Al Kabbani, Boris Görg, Masahiro Fujii, Phillip A. Lang, Dieter Häussinger, Roland P. Piekorz, Kai Stühler, Mohammad R. Ahmadian   +12 more
openaire   +3 more sources

Fragile X mental retardation protein interacts with the RNA-binding protein Caprin1 in neuronal RiboNucleoProtein complexes [corrected].

PLoS ONE, 2012
Fragile X syndrome is caused by the absence of the Fragile X Mental Retardation Protein (FMRP), an RNA-binding protein. FMRP is associated with messenger RiboNucleoParticles (mRNPs) present in polyribosomes and its absence in neurons leads to alteration ...
Rachid El Fatimy, Sandra Tremblay, Alain Y Dury, Samuel Solomon, Paul De Koninck, John W Schrader, Edouard W Khandjian   +6 more
doaj   +1 more source

Premature recruitment of oocyte pool and increased mTOR activity in Fmr1 knockout mice and reversal of phenotype with rapamycin. [PDF]

, 2018
While mutations in the fragile X mental retardation-1 (FMR1) gene are associated with varying reproductive outcomes in females, the effects of a complete lack of FMR1 expression are not known.
Ascano, M, Mok-Lin, E, Rosenwaks, Z, Serganov, A, Tuschl, T, Williams, Z   +5 more
core   +2 more sources

Temperature Dependence of Paramagnetic Species in the Human Brain Tissue: An X‐Band EPR Study

Magnetic Resonance in Medicine, Volume 95, Issue 5, Page 3031-3043, May 2026.
ABSTRACT Purpose Paramagnetic ions are distributed throughout the human brain. The increased accumulation of these metals, such as iron and copper, can induce cellular death and the development of neurological diseases. Electron Paramagnetic Resonance (EPR) is a spectroscopic technique capable of detecting these ions in a given biological sample ...
André Avanzine, José Henrique Monteiro de Azevedo, Martina Huber, Fábio Seiji Otsuka, Maria Concepción García Otaduy, Roberta Diehl Rodriguez, Carlos Ernesto Garrido Salmon   +6 more
wiley   +1 more source

FMRP is associated to the ribosomes via RNA [PDF]

Human Molecular Genetics, 1996
The FMR1 transcript is alternatively spliced and generates different splice variants coding for FMR1 proteins (FMRP) with a predicted molecular mass of 70-80 kDa. FMRP is widely expressed and localized in the cytoplasm. To study a possible interaction with other cellular components, FMRP was isolated and characterized under non-denaturing conditions ...
F, Tamanini, N, Meijer, C, Verheij, P J, Willems, H, Galjaard, B A, Oostra, A T, Hoogeveen   +6 more
openaire   +2 more sources

Paradoxical roles of the neutrophil in sepsis: protective and deleterious

Frontiers in Immunology, 2016
Sepsis, an overwhelming inflammatory response syndrome secondary to infection, is one of the costliest and deadliest medical conditions worldwide.
Fabiane eSônego, Fabiane eSônego, Fernanda Vargas e Silva Castanheira, Raphael Gomes Ferreira, Alexandre eKanashiro, Caio Abner Vitorino Golçalves Leite, Daniele Carvalho Nascimento, David Fernando Colón, Vanessa Fátima Borges, José C Alves-Filho, Fernando Queiróz Cunha   +10 more
doaj   +1 more source

Assessing Age‐Associated Influences on Paramagnetic and Diamagnetic Susceptibility Maps in Postmortem Human Brains

NMR in Biomedicine, Volume 39, Issue 5, May 2026.
We applied the APART‐QSM method to in situ postmortem MRI from 47 subjects (31–91 years) to assess age effects on paramagnetic and diamagnetic susceptibility. Diamagnetic susceptibility declined with age in basal ganglia, possibly reflecting shared biological factors.
José Henrique Monteiro de Azevedo, Maria Concepción Garcia Otaduy, Andre Avanzine, Roberta Diehl Rodriguez, Fábio Seiji Otsuka, Fernando Barbosa Jr., Chunlei Liu, Carlos Ernesto Garrido Salmon   +7 more
wiley   +1 more source