Results 101 to 110 of about 6,156 (251)

Association of the fibronectin type III domain–containing protein 5 rs1746661 single nucleotide polymorphism with reduced brain glucose metabolism in elderly humans [PDF]

, 2023
Fibronectin type III domain–containing protein 5 (FNDC5) and its derived hormone, irisin, have been associated with metabolic control in humans, with described FNDC5 single nucleotide polymorphisms being linked to obesity and metabolic syndrome ...
Benedet, Andréa L., De Bastiani, Marco Antônio, De Felice, Fernanda Guarino, Ferreira, Danielle Cozachenco, Ferreira, Sérgio Teixeira, Lima Filho, Ricardo André Santana, Lourenço, Mychael Vinícius da Costa, Povala, Guilherme, Rosa Neto, Pedro, Zimmer, Eduardo Rigon   +9 more
core  

Aerobic Exercise Restores Hippocampal Neurogenesis and Cognitive Function by Decreasing Microglia Inflammasome Formation Through Irisin/NLRP3 Pathway

Aging Cell, EarlyView.
Exercise improved PD pathology and memory by reducing microglial inflammation, apoptosis, and the formation of the NLRP3 inflammasome via irisin signaling. Irisin administration partially replicated the beneficial effects of exercise on PD pathology.
Renqing Zhao, Xin Tian, Haocheng Xu, Yuanxin Wang, Junjie Lin, Bin Wang   +5 more
wiley   +1 more source

Treadmill Exercise Alleviates Cognition Disorder by Activating the FNDC5: Dual Role of Integrin αV/β5 in Parkinson’s Disease

International Journal of Molecular Sciences, 2023
Parkinson’s disease with cognitive impairment (PD-CI) results in several clinical outcomes for which specific treatment is lacking. Although the pathogenesis of PD-CI has not yet been fully elucidated, it is related to neuronal plasticity decline in the ...
Chuanxi Tang, Mengting Liu, Zihang Zhou, Hao Li, Chenglin Yang, Li Yang, Jie Xiang   +6 more
semanticscholar   +1 more source

FNDC5/irisin mediates the protective effects of Innovative theta-shaking exercise on mouse memory

Heliyon
Runhong Yao, Kouji Yamada, Sho Izawa, Takumi Kito, Hirohide Sawada, Takeshi Chihara, Naoki Aizu, Daiki Iwata, Kazuhiro Nishii   +8 more
openalex   +2 more sources

Housing temperature influences exercise‐induced glucose regulation and expression of exerkines in mice

Experimental Physiology, EarlyView.
Abstract The impact of housing temperature on exercise‐induced metabolic adaptations is not well understood, despite extensive research on the benefits of exercise for metabolic health. The aim of this study was to elucidate how housing temperatures influence the molecular responses and metabolic benefits of exercise in mice.
Zhijian Rao, Xue Geng, Peng Huang, Qiangman Wei, Shijie Liu, Chaoyi Qu, Jiexiu Zhao   +6 more
wiley   +1 more source

Differential mitochondrial adaptation and FNDC5 production in brown and white adipose tissue in response to cold and obesity

Obesity
Fibronectin type III domain‐containing protein 5 (FNDC5) modulates adipocyte metabolism by increasing white and brown adipose tissue (WAT and BAT) browning and activity, respectively.
Gabriela Neira, Ana Wenting Hernández-Pardos, S. Becerril, B. Ramírez, V. Valentí, R. Moncada, V. Catalán, J. Gómez-Ambrosi, M. A. Burrell, Camilo Silva, J. Escalada, G. Frühbeck, Amaia Rodríguez   +12 more
semanticscholar   +1 more source

FNDC5/Irisin Inhibits the Inflammatory Response and Mediates the Aerobic Exercise-Induced Improvement of Liver Injury after Myocardial Infarction

International Journal of Molecular Sciences, 2023
Myocardial infarction (MI) causes peripheral organ injury, in addition to cardiac dysfunction, including in the liver, which is known as cardiac hepatopathy.
Tao Wang, Mengyuan Yu, Hangzhuo Li, Shuguang Qin, Wujing Ren, Yixuan Ma, Wenyan Bo, Yue Xi, Mengxin Cai, Zhenjun Tian   +9 more
semanticscholar   +1 more source

Irisin enhances longevity by boosting SIRT1, AMPK, autophagy and telomerase [PDF]

, 2022
Ageing is characterised by the accumulation of molecular and cellular damage through time, leading to a decline in physical and mental abilities. Currently, society has experienced a rapid increase in life expectancy, which has led to an increase in age ...
Cano Rodríguez, Mercedes, Muñoz Pinto, Mario Faustino, Sánchez Aliena   +2 more
core   +1 more source

The central benefit of physiologically induced ketogenic states

The Journal of Physiology, EarlyView.
Abstract figure legend This review describes the association between ketogenic states induced by physiological interventions such as fasting or aerobic exercise, exogenous ketone supply and ketogenic diets, as well as increased cognition through increased activity of brain‐derived neurotrophic factor (BDNF).
Antonia Giacco, Giuseppe Petito, Rosalba Senese, Maria Moreno, Assunta Lombardi, Antonia Lanni, Pieter de Lange   +6 more
wiley   +1 more source

CRISPRa‐based activation of Fgf21 and Fndc5 ameliorates obesity by promoting adipocytes browning

Clinical and Translational Medicine, 2023
Background Skeletal muscle‐secreted myokines widely participate in lipids metabolism through autocrine, paracrine and endocrine actions. The myokines represented by FGF21 and Irisin can promote the browning of adipocytes and serve as promising targets ...
Hongtao Zhu, Dan Liu, Ming Sui, Meiling Zhou, Beibei Wang, Qinqin Qi, Ting Wang, Guo Zhang, Feng Wan, Bin Zhang   +9 more
semanticscholar   +1 more source