Results 101 to 110 of about 5,116 (221)

FNDC5/irisin ameliorates bone loss of type 1 diabetes by suppressing endoplasmic reticulum stress‑mediated ferroptosis

Journal of Orthopaedic Surgery and Research
Ferroptosis is known to play a crucial role in diabetic osteopathy. However, key genes and molecular mechanisms remain largely unclear. This study aimed to identify a crucial ferroptosis-related differentially expressed gene (FR-DEG) in diabetic ...
Qianqian Dong, Ziqi Han, Mingdong Gao, Limin Tian   +3 more
semanticscholar   +1 more source

Effect of exercise training on the FNDC5/BDNF pathway in spontaneously hypertensive rats

Physiological Reports, 2019
Increased sympathetic activity contributes to the development of cardiovascular diseases such as hypertension. Exercise training lowers sympathetic activity and is beneficial for the prevention and treatment of hypertension and associated cognitive ...
Tao Wang, Melissa T. Maltez, Heow Won Lee, Monir Ahmad, Hong‐Wei Wang, Frans H. H. Leenen   +5 more
doaj   +1 more source

FNDC5 induces M2 macrophage polarization and promotes hepatocellular carcinoma cell growth by affecting the PPARγ/NF-κB/NLRP3 pathway

, 2021
Huayuan Liu, Mengya Wang, Zhipeng Jin, Dongxu Sun, Ting Zhu, Xinyue Liu, Xueying Tan, Guangjun Shi   +7 more
openalex   +1 more source

Increased FNDC5 is associated with insulin resistance in high fat-fed mice

Physiological Reports, 2017
FNDC5/irisin, has recently been identified as a novel protein that stimulates the "browning" of white adipose by inducing thermogenesis via increased uncoupling protein 1 (UCP1). We tested the hypothesis that high fat diet-induced prediabetic mice would exhibit increased FNDC5 and this effect would be attenuated by chronic exercise.
Guilford, Brianne L., Parson, Jake C., Grote, Caleb W., Vick, Stephanie N., Ryals, Janelle M., Wright, Douglas E.   +5 more
openaire   +2 more sources

Effect of saffron aqueous extract during resistance training on the expression of fibronectin type III domain-containing protein 5 in the hippocampus of rats with type 2 diabetes [PDF]

Complementary Medicine Journal of Faculty of Nursing and Midwifery
Introduction: It has been demonstrated that fibronectin type III domain-containing protein 5 (FNDC5) improves cognitive function by increasing neurotrophic factors. Furthermore, type 2 diabetes causes a decrease in cognitive function. The combined effect
Farzad Baratyan, Vahid Valipour dehnou, Amir Khosravi   +2 more
doaj  

Therapeutic potential of exercise-hormone irisin in Alzheimer’s disease

Neural Regeneration Research
Irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type III domain-containing protein 5 (FNDC5) in response to physical exercise.
Eunhee Kim, Rudolph E. Tanzi, Se Hoon Choi   +2 more
doaj   +1 more source

The Effects of Irisin Hormone and the FNDC5 Gene on Brain Functions and Exercise: A Systematic Review

, 2022
Özgür Eken
openalex   +2 more sources

Effects of High-Intensity Interval Vs. Moderate-Intensity Continuous Training on Body Composition and Gene Expression of ACE2, NLRP3, and FNDC5 in Obese Adults: A Randomized Controlled Trial [PDF]

, 2022
Fariba Armannia, Farshad Ghazalian, Mahdi Shadnoush, Hossein Keyvani, Mandana Gholami   +4 more
openalex   +1 more source

Increased FNDC5 (irisin) expression in subcutaneous adipose tissue in obese patients with type 2 diabetes 1 year after bariatric surgery [PDF]

, 2015
Julia Muenzker, Alexandra Harger, Alexandru Tuca, Lisa Lindheim, Verena Zachhuber, Eva Švehlíková, Oana Freisinger, J. Fruhmann, Friedrich Tadler, Thomas R. Pieber, Barbara Obermayer‐Pietsch   +10 more
openalex   +1 more source

Iditarod , a Drosophila homolog of the Irisin precursor FNDC5 , is critical for exercise performance and cardiac autophagy

, 2023
Tyler Cobb, Irene Hwang, Michael Soukar, Sim Namkoong, Uhn‐Soo Cho, Maryam Safdar, Myungjin Kim, Robert Wessells, Jun Hee Lee   +8 more
openalex   +1 more source