Results 191 to 200 of about 5,116 (221)

MiR-143-3p/FNDC5 axis: a novel regulator of insulin sensitivity

Endocrine, 2023
Insulin resistance is a key hallmark in type 2 diabetes. In recent decades, there have been numerous studies of the causes of insulin resistance. microRNAs (miRNAs) participate in the regulation of multiple aspects of energy metabolism and miR-143-3p has been shown to induce insulin resistance.
Biao Li, Ying Dong, Siyuan Hu, Tiancai Liu   +3 more
openaire   +2 more sources

Auricular acupuncture induces FNDC5/irisin and attenuates obese inflammation in mice

Acupuncture in Medicine, 2020
Objective: To investigate whether auricular acupuncture (AA) attenuates bodyweight and obese inflammation through the release of irisin from muscle tissue in mice. Methods: Sixty 4-week-old mice were fed a high fat diet (HFD) for 4 weeks. These animals were divided into six groups that remained untreated (HFD) or underwent electrical AA (HFD+EAA), sham
Yi, Lu, Guohua, Li
openaire   +2 more sources

The Expression Characteristics and Interrelationships of FNDC5 and Pyroptosis-Associated Molecules in the Peripheral Blood of Patients with Coronary Heart Disease.

Current protein and peptide science
OBJECTIVES The aim of this study was to investigate the expression characteristics and interrelationships of FNDC5 and pyroptosis-associated molecules in peripheral blood mononuclear cells of patients with coronary heart disease (CHD). METHODS Patients
Yujia Pan, Hangjun Ou, Danan Liu
semanticscholar   +1 more source

The cerebroprotection and prospects of FNDC5/irisin in stroke

Neuropharmacology
Stroke, the leading cause of disability and cognitive impairment, is also the second leading cause of death worldwide. The drugs with multi-targeted brain cytoprotective effects are increasingly being advocated for the treatment of stroke. Irisin, a newly discovered myokine produced by cleavage of fibronectin type III domain 5, has been shown to ...
Yuanyuan Liu, Yang Liu, Xiangyu Zhang, Gaili Yan, Lingxiao Qi, V. Wee Yong, Mengzhou Xue   +6 more
openaire   +2 more sources

Role of Irisin/FNDC5 (rs3480) Single Nucleotide Polymorphism in Breast Cancer.

SECI Oncology Journal
: Background: Breast cancer is the most common malignancy among women and remains a leading cause of cancer-related mortality. Previous studies suggest that the FNDC5/irisin gene may exert a protective role against breast cancer, as reduced expression ...
AH Abdelall, AH Fathy, Abdallah Aam, SB Hemdan, A. Abdelall, Asmaa Hussein Fathy, Ahmed Alamir, Mahmoud Abdallah, S. Hemdan   +8 more
semanticscholar   +1 more source

Fndc5 overexpression facilitated neural differentiation of mouse embryonic stem cells

Cell Biology International, 2015
AbstractFndc5 has been recently recognized as a myokine which could be cleaved and secreted into blood stream. It is termed as irisin with an important role in thermogenesis and energy homeostasis. Increased expression of Fndc5 has been reported upon retinoic acid treatment during neural differentiation and its knockdown decreased neural ...
Mahboobeh, Forouzanfar, Farzaneh, Rabiee, Kamran, Ghaedi, Siamak, Beheshti, Somayeh, Tanhaei, Alireza, Shoaraye Nejati, Mohammad, Jodeiri Farshbaf, Hossein, Baharvand, Mohammad Hossein, Nasr-Esfahani   +8 more
openaire   +2 more sources

Association of metabolic parameters and rs726344 in FNDC5 with serum irisin concentrations

International Journal of Obesity, 2015
Irisin has been suggested as a novel myokine with beneficial effects in rodents. However, previous data in humans showed conflicting results regarding its association with metabolic phenotypes and regulation of secretion. Furthermore, although an association of rs726344 in FNDC5 (fibronectin type III domain containing 5) coding for irisin with insulin ...
T Ebert, S Kralisch, U Wurst, M Scholz, M Stumvoll, P Kovacs, M Fasshauer, A Tönjes   +7 more
openaire   +2 more sources

Effects of Aerobic Exercise and Resistance Training on Cognitive Function: Comparative Study Based on FNDC5/Irisin/BDNF Pathway

Dementia and Geriatric Cognitive Disorders
Introduction: Exercise has been recommended to suppress or prevent cognitive decline. Aerobic exercise (AE) may suppress cognitive decline via the fibronectin type III domain-containing protein 5 (FNDC5)/irisin/brain-derived neurotrophic factor (BDNF ...
Shotaro Izawa, K. Nishii, Naoki Aizu, Takumi Kito, Daiki Iwata, Takeshi Chihara, Hirohide Sawada, Runhong Yao, Kouji Yamada   +8 more
semanticscholar   +1 more source

Exosomal irisin from FNDC5-engineered BMSCs improves ischemic stroke via inhibiting YAP/EGR1/ACSL4-mediated ferroptosis

Experimental Neurology
Cuini Fang, Lei Huang, Jiayi Gu, Tao Song   +3 more
semanticscholar   +1 more source

Irisin/FNDC5 regulate carbohydrate metabolism in the exocrine pancreas

Pancreatology, 2023
Avital Horwitz, Ruth Birk
openaire   +1 more source