Results 201 to 210 of about 7,212 (245)

Cleavage of FNDC5 and insights into its maturation process

Molecular and Cellular Endocrinology, 2020
FNDC5 corresponds to an irisin precursor that increases with exercise. Studies suggest that irisin mediates beneficial effects in adipose tissues, skeletal muscle, bone, and brain. However, the cleavage and maturation processes of FNDC5 have not been clearly identified.
Yongwei Nie
exaly   +3 more sources

Sestrin/FNDC5: An ancient axis connecting exercise and thermoregulation

Acta Physiologica, 2022
Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/172016/1/apha13804.pdf ; http://deepblue.lib.umich.edu/bitstream/2027.42/172016/2/apha13804_am ...
Robert J. Wessells, Jun‐Hee Lee
openaire   +3 more sources

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway [PDF]

Cell Metabolism, 2013
Exercise can improve cognitive function and has been linked to the increased expression of brain-derived neurotrophic factor (BDNF). However, the underlying molecular mechanisms driving the elevation of this neurotrophin remain unknown. Here we show that FNDC5, a previously identified muscle protein that is induced in exercise and is cleaved and ...
Christiane D Wrann, Jun Wu, Yan Lu
exaly   +3 more sources

FNDC5/Irisin inhibits pathological cardiac hypertrophy

Clinical Science, 2019
Abstract Cardiac hypertrophy is a common pathophysiological process in various cardiovascular diseases, which still has no effective therapies. Irisin is a novel myokine mainly secreted by skeletal muscle and is believed to be involved in the regulation of energy metabolism.
Qing Yu, Wenxin Kou, Xu Xu, Shunping Zhou, Peipei Luan, Xiaopeng Xu, Hailing Li, Jianhui Zhuang, Jun Wang, Yifan Zhao, Yawei Xu, Wenhui Peng   +11 more
openaire   +2 more sources

MiR-143-3p/FNDC5 axis: a novel regulator of insulin sensitivity

Endocrine, 2023
Insulin resistance is a key hallmark in type 2 diabetes. In recent decades, there have been numerous studies of the causes of insulin resistance. microRNAs (miRNAs) participate in the regulation of multiple aspects of energy metabolism and miR-143-3p has been shown to induce insulin resistance.
Biao Li, Ying Dong, Siyuan Hu, Tiancai Liu   +3 more
openaire   +2 more sources

Exosomal irisin from FNDC5-engineered BMSCs improves ischemic stroke via inhibiting YAP/EGR1/ACSL4-mediated ferroptosis.

Experimental Neurology
BACKGROUND BMSCs-derived exosomes play an important role in ischemic stroke. Irisin and its precursor fibronectin type III domain-containing protein 5 (FNDC5) are implicated in neuroprotective effect.
Cuini Fang, Lei Huang, Jiayi Gu, Tao Song   +3 more
semanticscholar   +1 more source

Targeting the muscle-brain axis to improve post-stroke cognition via the FNDC5/irisin/BDNF pathway.

Journal of Advanced Research
INTRODUCTION The muscle-brain axis involving FNDC5/irisin/BDNF supports brain health and cognition. Stroke often causes hemiplegic muscle atrophy, which may disrupt this axis and impair cognition.
Jiating Wei, Yuangui Cai, Zimu Jiang, Jia Xie, D. Xie, Fubing Ouyang, Jianle Li, Zhiyi Xiong, Xiya Long, Miaoxian Yang, L. Zha, Yingxin He, Weixian Huang, J. Zeng   +13 more
semanticscholar   +1 more source

Auricular acupuncture induces FNDC5/irisin and attenuates obese inflammation in mice

Acupuncture in Medicine, 2020
Objective: To investigate whether auricular acupuncture (AA) attenuates bodyweight and obese inflammation through the release of irisin from muscle tissue in mice. Methods: Sixty 4-week-old mice were fed a high fat diet (HFD) for 4 weeks. These animals were divided into six groups that remained untreated (HFD) or underwent electrical AA (HFD+EAA), sham
Yi, Lu, Guohua, Li
openaire   +2 more sources

Exercise-induced interactions between skeletal muscle and bone via myokines and osteokine in mice: Role of FNDC5/irisin, IGF-1, and osteocalcin.

Bone
Skeletal muscle and bone interact to maintain their structure and function. Physical exercise is the most effective and easily applicable strategy to maintain their functions; however, exercise-induced interactions by soluble factors remained elusive ...
Junpei Hatakeyama, Shota Inoue, Hanlin Jiang, Ryo Yokoi, Hideki Moriyama   +4 more
semanticscholar   +1 more source

Association of the FNDC5 rs1746661 single nucleotide polymorphism with reduced brain glucose metabolism in elderly humans

Dementia & Neuropsychologia
Fibronectin type III domain—containing protein 5 (FNDC5) and its derived hormone, irisin, have been associated with metabolic control in humans, with described FNDC5 single nucleotide polymorphisms being linked to obesity and metabolic syndrome ...
R. Lima-Filho, A. Benedet, Marco Antônio de Bastiani, G. Povala, Danielle Cozachenco, S. Ferreira, F. D. Felice, P. Rosa-Neto, E. Zimmer, Mychael V. Lourenco   +9 more
semanticscholar   +1 more source