Results 211 to 220 of about 7,212 (245)

The cerebroprotection and prospects of FNDC5/irisin in stroke

Neuropharmacology
Stroke, the leading cause of disability and cognitive impairment, is also the second leading cause of death worldwide. The drugs with multi-targeted brain cytoprotective effects are increasingly being advocated for the treatment of stroke. Irisin, a newly discovered myokine produced by cleavage of fibronectin type III domain 5, has been shown to ...
Yuanyuan Liu, Yang Liu, Xiangyu Zhang, Gaili Yan, Lingxiao Qi, V. Wee Yong, Mengzhou Xue   +6 more
openaire   +2 more sources

Quercetin enhances muscle FNDC5/irisin, partly through AMPK activation, and induces white adipose tissue browning in high-fat-fed rats.

Archives of Biochemistry and Biophysics
Irisin is a myokine released during physical activity that contributes to the browning of white adipose tissue (WAT), providing various metabolic benefits.
Victoria Muscia Saez, D. J. Perdicaro, Cecilia Rodríguez Lanzi, E. Cremonini, Patricia I. Oteiza, Marcela A Vazquez Prieto   +5 more
semanticscholar   +1 more source

Fndc5 overexpression facilitated neural differentiation of mouse embryonic stem cells

Cell Biology International, 2015
AbstractFndc5 has been recently recognized as a myokine which could be cleaved and secreted into blood stream. It is termed as irisin with an important role in thermogenesis and energy homeostasis. Increased expression of Fndc5 has been reported upon retinoic acid treatment during neural differentiation and its knockdown decreased neural ...
Mahboobeh, Forouzanfar, Farzaneh, Rabiee, Kamran, Ghaedi, Siamak, Beheshti, Somayeh, Tanhaei, Alireza, Shoaraye Nejati, Mohammad, Jodeiri Farshbaf, Hossein, Baharvand, Mohammad Hossein, Nasr-Esfahani   +8 more
openaire   +2 more sources

The Expression Characteristics and Interrelationships of FNDC5 and Pyroptosis-Associated Molecules in the Peripheral Blood of Patients with Coronary Heart Disease.

Current protein and peptide science
OBJECTIVES The aim of this study was to investigate the expression characteristics and interrelationships of FNDC5 and pyroptosis-associated molecules in peripheral blood mononuclear cells of patients with coronary heart disease (CHD). METHODS Patients
Yujia Pan, Hangjun Ou, Danan Liu
semanticscholar   +1 more source

Role of Irisin/FNDC5 (rs3480) Single Nucleotide Polymorphism in Breast Cancer.

SECI Oncology Journal
: Background: Breast cancer is the most common malignancy among women and remains a leading cause of cancer-related mortality. Previous studies suggest that the FNDC5/irisin gene may exert a protective role against breast cancer, as reduced expression ...
AH Abdelall, Ahmed Fathy, Abdallah Aam, SB Hemdan, A. Abdelall, Asmaa Hussein Fathy, A. Alamir, M. Abdallah, S. Hemdan   +8 more
semanticscholar   +1 more source

Epigenetic upregulation of FNDC5/irisin via CRISPR-dCas9 as a therapeutic approach for Alzheimer’s disease

Dementia & Neuropsychologia
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting over 50 million people globally, with no effective treatment. It is well established that exercise improves brain health and protects against AD, partly by increasing levels ...
Thyago Leal-Calvo, R. L. Franco, Ilana Burg, Viviana Salinas-Rios, Fyodor D. Urnov, F. D. Felice   +5 more
semanticscholar   +1 more source

In vitro Activation of Brown Adipocyte Thermogenesis by Fermented Hypholomine B-enriched Sanghuangporus sanghuang Mycelia Through FNDC5/Irisin Pathway.

Molecular and Cellular Endocrinology
In the face of the global obesity epidemic (globesity), we present the first comprehensive investigation of fermented Sanghuangporus sanghuang mycelia extract (SS-IM1) and its novel bioactive compound hypholomine B in brown adipose tissue activation ...
I-Chen Li, Y. Chan, Yu-Li Lin, Tzong-Yuan Wu, Liang Wu, Ching-Yi Tsai, Hsin-Tang Lin, Chin-Chu Chen   +7 more
semanticscholar   +1 more source

Reduced FNDC5-AMPK signaling in diabetic atrium increases the susceptibility of atrial fibrillation by impairing mitochondrial dynamics and activating NLRP3 inflammasome.

Biochemical Pharmacology
Fibronectin type III domain-containing protein 5 (FNDC5) exerts potential anti-arrhythmic effects. However, the function and mechanism of FNDC5 in diabetes-associated atrial fibrillation (AF) remain unknown.
Shan Meng, Xin Chen, Jikai Zhao, Xinyi Huang, Yuting Huang, Tao Huang, Zijun Zhou, Wenpu Ren, Tao Hong, Jinfeng Duan, Liming Yu, Huishan Wang   +11 more
semanticscholar   +1 more source

Association of metabolic parameters and rs726344 in FNDC5 with serum irisin concentrations

International Journal of Obesity, 2015
Irisin has been suggested as a novel myokine with beneficial effects in rodents. However, previous data in humans showed conflicting results regarding its association with metabolic phenotypes and regulation of secretion. Furthermore, although an association of rs726344 in FNDC5 (fibronectin type III domain containing 5) coding for irisin with insulin ...
T Ebert, S Kralisch, U Wurst, M Scholz, M Stumvoll, P Kovacs, M Fasshauer, A Tönjes   +7 more
openaire   +2 more sources

Exercise training alleviates symptoms and cognitive decline in a reserpine-induced fibromyalgia model by activating hippocampal PGC-1α/FNDC5/BDNF pathway.

Neuroscience
The purpose of this study was to assess, from a behavioral, biochemical, and molecular standpoint, how exercise training affected fibromyalgia (FM) symptoms in a reserpine-induced FM model and to look into the potential involvement of the hippocampal PGC-
M. Belviranlı, N. Okudan, Tuğba Sezer
semanticscholar   +1 more source