Results 41 to 50 of about 5,116 (221)
Biomolecules, 2021 Irisin is an exercise-induced myokine, suggested to exert beneficial effects on metabolism. However, the studies on the regulation of irisin secretion and the expression of its precursor FNDC5 have shown conflicting data. The discrepancies among previous
Songling Jiang +4 more
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FNDC5/Irisin: A New Protagonist in Acute Brain Injury [PDF]
Stem Cells and Development, 2020 Acute brain injury (ABI), including stroke and traumatic brain injury, which accounts for a heavy burden of morbidity and mortality, results in a great loss of productive life and serious health problem worldwide. To improve patients' survival and ameliorate their outcome, effective clinical treatment strategies and new therapeutic targets are urgently
Tianqi, Tu, Jianhua, Peng, Yong, Jiang
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Stem Cell Research & Therapy, 2020 Background The beneficial functions of bone marrow mesenchymal stem cells (BM-MSCs) decline with decreased cell survival, limiting their therapeutic efficacy for myocardial infarction (MI).
Jingyu Deng +9 more
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Acute Effects of Aerobic Treadmill Exercise Intensity on Expression of Irisin and FNDC5 in Male Mouse [PDF]
운동과학, 2018 PURPOSE The purpose of this study was to compare the differences in the expression of FNDC5 and irisin according to the intensity of exercise and to determine the most effective exercise intensity for the expression of FNDC5 and irisin immediately after ...
Hyun Namgoong +3 more
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Glucocorticoid receptor positively regulates transcription of FNDC5 in the liver [PDF]
Scientific Reports, 2017 AbstractIrisin is secreted by skeletal muscle during exercise and influences energy and metabolic homeostasis. This hormone is a cleaved and secreted fragment of fibronectin type III domain-containing 5 (FNDC5). Elucidation of the FNDC5 gene regulation mechanism is necessary to clarify the function of irisin as a potential therapeutic target in human ...
Kim, Hyoung Kyu +6 more
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FNDC5 Promotes Adipogenic Differentiation of Primary Preadipocytes in Mashen Pigs
Genes, 2022 Fibronectin type III domain-containing protein 5 (FNDC5) plays an important role in fat deposition, which can be cut to form Irisin to promote fat thermogenesis, resulting in a decrease in fat content. However, the mechanism of FNDC5 related to fat deposition in pigs is still unclear.
Hei, Wei +12 more
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Antioxidants, 2022 Irisin, a novel myokine, is secreted by the muscle following proteolytic cleavage of fibronectin type III domain containing 5 (FNDC5) and is considered a novel regulator of glucose homeostasis.
Rajesh Parsanathan, Sushil K. Jain
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Corrigendum to "FNDC5/irisin mitigates the cardiotoxic impacts of cancer chemotherapeutics by modulating ROS-dependent and -independent mechanisms" [Redox Biol. 80 (2025) 103527]. [PDF]
Redox BiolKumar M +9 more
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Raspberry ketone promotes FNDC5 protein expression via HO-1 upregulation in 3T3-L1 adipocytes
Chinese Journal of Physiology, 2022 Obesity is a global health problem and a risk factor for cardiovascular diseases and cancers. Exercise is an effective intervention to combat obesity. Fibronectin type III domain containing protein 5 (FNDC5)/irisin, a myokine, can stimulate the browning ...
Yung-Chieh Tsai +4 more
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PLoS ONE, 2014 The transmembrane protein FNDC5 was recently characterized as precursor of an exercise induced myokine named irisin. Previous studies found a relationship between circulating irisin levels and muscle mass in humans. Consequently, we tested the hypothesis
Katrin Komolka +5 more
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