Results 41 to 50 of about 6,156 (251)

FNDC5/Irisin counteracts lipotoxic-induced apoptosis in hypoxic H9c2 cells [PDF]

Journal of Molecular Endocrinology, 2019
Irisin is a newly identified adipokine critical to modulate body metabolism, fatty acid metabolism and oxidative stress; recent evidence suggests a cardioprotective role in ischemic injury. Loss of cardiomyocytes during acute myocardial infarction is strongly associated with energetic changes and lipotoxic-induced apoptosis.
Isabel Moscoso, María Cebro-Márquez, Moisés Rodríguez‐Mañero, José Ramón González‐Juanatey, Ricardo Lage   +4 more
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FNDC5/Irisin in dementia and cognitive impairment: update and novel perspective [PDF]

Brazilian Journal of Medical and Biological Research
Epidemiological surveys show that the incidence of age-related dementia and cognitive impairment is increasing and it has been a heavy burden for society, families, and healthcare systems, making the preservation of cognitive function in an increasingly aging population a major challenge. Exercise is beneficial for brain health, and FDNC5/irisin, a new
Xiaofeng Guo, Xiaocheng Huang, Yachao Yang, Luying Dong, Dehuan Kong, Jianmei Zhang   +5 more
openaire   +4 more sources

Therapeutic potential of exercise-hormone irisin in Alzheimer’s disease [PDF]

Neural Regeneration Research
Irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type III domain-containing protein 5 (FNDC5) in response to physical exercise.
Eunhee Kim, Rudolph E. Tanzi, Se Hoon Choi   +2 more
doaj   +2 more sources

A role for FNDC5/Irisin in the beneficial effects of exercise on the brain and in neurodegenerative diseases [PDF]

Progress in Cardiovascular Diseases, 2019
The beneficial effects of exercise on the brain are well known. However, the underlying molecular mechanisms are much less well understood. Interestingly, myokines, hormones secreted by muscle in response to exercise, gained attention as such beneficial mediators.
Michael Young, Sophia Valaris, Christiane D. Wrann   +2 more
openalex   +4 more sources

Artificial Neural Network Inference (ANNI): A Study on Gene-Gene Interaction for Biomarkers in Childhood Sarcomas [PDF]

, 2014
Objective: To model the potential interaction between previously identified biomarkers in children sarcomas using artificial neural network inference (ANNI).
A Gupta, A Sengupta, A Uren, A Yoshida, B Djavan, B Matharoo-Ball, B Schwikowski, Christophe Lemetre, CM Milner, David J. Boocock, DJ Mahoney, DL Cottle, DN Lopes, Dong Ling Tong, DR Czuchlewski, E Clarkson, Francesco Pappalardo, Gopal Krishna R. Dhondalay, Graham R. Ball, H De Jong, IA Maraziotis, ID Coghill, J Khan, JG Taylor, JJ Johnston, JS Wei, JY Huh, K Nishii, L Cheng, M Fortier, M Geryk-Hall, M Stock, M Sáinz-Jaspeado, MC O’Neill, MJ Morgan, NJ Parkinson, P Sharp, Q Li, R Albert, R Rimokh, R Xu, S Bhattacharyya, S Krebs, S Neumann, SH Lecker, SP Kodithuwakku, T Breidthardt, TJ Pianta, V Gomes A, V Spirin, W Liu, X Li, Y Benjamini, Z-Z Wu   +53 more
core   +10 more sources

Expression of Irisin/FNDC5 in Breast Cancer

International Journal of Molecular Sciences, 2022
Irisin is a myokine formed from fibronectin type III domain-containing protein 5 (FNDC5), which can be found in various cancer tissues. FNDC5 and irisin levels have been poorly studied in the tumor tissues of breast cancer (BC). The aim of this study was to determine the levels of irisin expression in BC tissues and compare them to clinicopathological ...
Kamil Cebulski, Katarzyna Nowińska, Karolina Jablońska, Hanna Romanowicz, Beata Smolarz, Piotr Dzięgiel, Marzenna Podhorska-Okołów   +6 more
openaire   +2 more sources

Irisin/FNDC5: A participant in camel metabolism

Saudi Journal of Biological Sciences, 2021
The quantification, localization, production, function, and regulation of irisin/FNDC5 in camel species have not been previously studied. The objective of this study was to detect the irisin content in Arabian camel blood and tissues and study the gene expression of FNDC5 and PGC-1α in camel skeletal muscles and white adipose tissue depots under basal ...
Mohamed Hamada, Doaa Kirat, Amira Moustafa, Taku Miyasho   +3 more
openaire   +2 more sources

Significance of Irisin (FNDC5) Expression in Colorectal Cancer [PDF]

In Vivo, 2021
The role of irisin, the extracellular part of fibronectin type III domain containing 5 (FNDC5), in colorectal cancer (CRC) is unclear. The aim of this study was to investigate immunohistochemical (IHC) expression level of irisin and correlations with clinicopathological factors in patients with CRC.We collected 222 archived CRC samples and 26 control ...
Slawomir, Wozniak, Katarzyna, Nowinska, Mariusz, Chabowski, Piotr, Dziegiel   +3 more
openaire   +2 more sources

Exercise rescues cognitive deterioration in naturally aged rats via PGC1α/FNDC5/irisin/AMPK signaling pathway to restore redox, endothelial, and neuronal homeostasis [PDF]

Bulletin of Egyptian Society for Physiological Sciences
Background: Aging-associated cognitive impairments become a global phenomenon, especially with the increase in life expectancy and sedentary lifestyle. Thus, the present study aimed to assess the cognitive functions in aged rats and explore the potential
Marwa Muhammad, Nashwa Ahmed, Noha Osama El-Shaer   +2 more
openalex   +2 more sources

Early Movement Restriction Affects FNDC5/Irisin and BDNF Levels in Rat Muscle and Brain [PDF]

International Journal of Molecular Sciences
Interaction with the environment appears necessary for the maturation of sensorimotor and cognitive functions in early life. In rats, a model of sensorimotor restriction (SMR) from postnatal day 1 (P1) to P28 has shown that low and atypical sensorimotor ...
Orlane Dupuis, J. Girardie, Mélanie Van Gaever, Philippe Garnier, Jacques‐Olivier Coq, Marie‐Hélène Canu, Erwan Dupont   +6 more
openalex   +2 more sources