Results 71 to 80 of about 1,381,729 (387)

Myxococcus xanthus gliding motors are elastically coupled to the substrate as predicted by the focal adhesion model of gliding motility

, 2014
Myxococcus xanthus is a model organism for studying bacterial social behaviors due to its ability to form complex multi-cellular structures. Knowledge of M.
Balagam, Rajesh, Czerwinski, Fabian, Igoshin, Oleg A., Kaplan, Heidi B., Litwin, Douglas B., Shaevitz, Joshua W., Sun, Mingzhai   +6 more
core   +3 more sources

An evolutionary and physiological perspective on cell-substrate adhesion machinery for cell migration

Frontiers in Cell and Developmental Biology, 2022
Cell-substrate adhesion is a critical aspect of many forms of cell migration. Cell adhesion to an extracellular matrix (ECM) generates traction forces necessary for efficient migration.
Julio C. Fierro Morales, Qian Xue, Minna Roh-Johnson   +2 more
doaj   +1 more source

Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo. [PDF]

, 1995
The NPXY sequence is highly conserved among integrin beta subunit cytoplasmic tails, suggesting that it plays a fundamental role in regulating integrin-mediated function.
Brooks, PC, Cheresh, DA, Damsky, C, Deming, SL, Filardo, EJ   +4 more
core   +2 more sources

Focal adhesions are controlled by microtubules through local contractility regulation

The EMBO Journal
Microtubules regulate cell polarity and migration via local activation of focal adhesion turnover, but the mechanism of this process is insufficiently understood.
Julien Aureille, Srinivas S Prabhu, Sam F Barnett, Aaron J Farrugia, Isabelle Arnal, Laurence Lafanechère, Boon Chuan Low, Pakorn Kanchanawong, Alex Mogilner, Alexander D Bershadsky   +9 more
doaj   +1 more source

Distinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions. [PDF]

, 1993
Integrin-mediated cell adhesion often results in cell spreading and the formation of focal adhesions. We exploited the capacity of recombinant human alpha IIb beta 3 integrin to endow heterologous cells with the ability to adhere and spread on fibrinogen
Chen, Y, Ginsberg, MH, Loftus, JC, O'Toole, TE, Takada, Y, Ylänne, J   +5 more
core  

ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion [PDF]

, 2016
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a dismal survival rate. Persistent activation of pancreatic stellate cells (PSCs) can perturb the biomechanical homoeostasis of the tumour microenvironment to favour cancer ...
Attwood, S, Auernheimer, V, Chronopoulos, A, Cortes, E, Del Rio Hernandez, AE, Fabry, B, Garcia, R, Ghassemi, S, Lachowski, D, Robinson, B, Sarper, M   +10 more
core   +1 more source

Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover

Journal of Cell Science, 2000
ABSTRACT Focal adhesion kinase (FAK) is activated and localized at focal adhesions upon cell adhesion to extracellular matrices. Cells lacking FAK show increased focal adhesion number and decreased cell migration, functions that are regulated by the small GTPase Rho.
X D, Ren, W B, Kiosses, D J, Sieg, C A, Otey, D D, Schlaepfer, M A, Schwartz   +5 more
openaire   +3 more sources

Exploring Preferences for a Digital Single‐Session Intervention for Adolescent Siblings of Youth With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Adolescent siblings of children with cancer are at elevated risk for psychosocial problems. Unfortunately, various barriers such as limited family time and resources, conflicting schedules, and psychosocial staffing constraints at cancer centers hinder sibling access to support.
Christina M. Amaro, Sarah Silver, Prishi Patel, Meredith K. Reffner Collins, Kimberly S. Canter, Stephanie Fooks‐Parker, Michael Amylon, Shawna V. Hudson, Jessica L. Schleider, Melissa A. Alderfer, Katie A. Devine   +10 more
wiley   +1 more source

Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity

Journal of Cell Biology, 2016
The cytoskeletal adapter protein talin plays a prominent role in adhesive structures connecting integrins to the actin cytoskeleton. In this work, Kumar et al.
Abhishek Kumar, Mingxing Ouyang, K. van den Dries, E. McGhee, Keiichiro Tanaka, M. D. Anderson, A. Groisman, B. Goult, K. Anderson, M. Schwartz   +9 more
semanticscholar   +1 more source

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation [PDF]

, 2014
The force-dependent interaction between talin and vinculin plays a crucial role in the initiation and growth of focal adhesions. Here we use magnetic tweezers to characterise the mechano-sensitive compact N-terminal region of the talin rod, and show that
A Banno, A Carisey, A Del Rio, A Kishino, AD Bershadsky, AR Gingras, BD Hoffman, BT Goult, BT Goult, C Ciobanasu, C Grashoff, E Goksoy, F Margadant, GCK Roberts, H Chen, H Chen, H Chen, H Fu, H Hirata, H-S Lee, H-S Lee, J Han, JD Humphries, NJ Anthis, PR Elliott, PRJ Bois, PRJ Bois, SE Lee, SJ Ellis, T Wieprecht, TJ Proszynski, V Vogel, Y Gao, Y Sawada, Y Sawada   +34 more
core   +2 more sources