Results 141 to 150 of about 156,176 (352)

ETV2 Mediated Differentiation of Human Pluripotent Stem Cells Results in Functional Endothelial Cells for Engineering Advanced Vascularized Microphysiological Models

Advanced Healthcare Materials, EarlyView.
A robust method to generate functional human iPSC‐derived endothelial cells using inducible ETV2 expression. These cells self‐organize into stable, lumenized microvascular networks within microfluidic chips, surpassing conventional differentiation methods.
Shun Zhang, Zhengpeng Wan, Lei Wang, Caihong Wu, Junkai Zhang, Sarah Spitz, Xun Wang, Marie A. Floryan, Mark F. Coughlin, Francesca M. Pramotton, Liling Xu, Ron Weiss, Roger D. Kamm   +12 more
wiley   +1 more source

Integrin α9 Suppresses Hepatocellular Carcinoma Metastasis by Rho GTPase Signaling

Journal of Immunology Research, 2018
Integrin subunit alpha 9 (ITGA9) mediates cell-cell and cell-matrix adhesion, cell migration, and invasion through binding different kinds of extracellular matrix (ECM) components.
Yan-Li Zhang, Xin Xing, Li-Bo Cai, Lei Zhu, Xiao-Mei Yang, Ya-Hui Wang, Qin Yang, Hui-Zhen Nie, Zhi-Gang Zhang, Jun Li, Xue-Li Zhang   +10 more
doaj   +1 more source

Activation of p21‐activated kinase 1 is required for lysophosphatidic acid‐induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cells [PDF]

, 2004
In Duk Jung, Jangsoon Lee, Kyung‐Bok Lee, Chang Gyo Park, Yong Kee Kim, Dong Wan Seo, Dongeun Park, Hyang Woo Lee, Jeung‐Whan Han, Hoi Young Lee   +9 more
openalex   +1 more source

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Focal adhesion kinase signaling in cardiac hypertrophy and failure

Brazilian Journal of Medical and Biological Research, 2009
Focal adhesion kinase (FAK) is a broadly expressed tyrosine kinase implicated in cellular functions such as migration, growth and survival. Emerging data support a role for FAK in cardiac development, reactive hypertrophy and failure.
K.G. Franchini, C.F.M.Z. Clemente, T.M. Marin   +2 more
doaj  

Spatial restriction of alpha4 integrin phosphorylation regulates lamellipodial stability and alpha4beta1-dependent cell migration. [PDF]

, 2003
Integrins coordinate spatial signaling events essential for cell polarity and directed migration. Such signals from alpha4 integrins regulate cell migration in development and in leukocyte trafficking.
Ginsberg, Mark H, Goldfinger, Lawrence E, Han, Jaewon, Howe, Alan K, Kiosses, William B   +4 more
core   +1 more source

The Cytoskeletal/Non-muscle Isoform of α-Actinin Is Phosphorylated on Its Actin-binding Domain by the Focal Adhesion Kinase [PDF]

, 2001
Gonzalo Izaguirre, Lina Aguirre, Ya-Ping Hu, Hwa Young Lee, David D. Schlaepfer, Brian J. Aneskievich, Beatrice Haimovich   +6 more
openalex   +1 more source

Elucidation of Focal Adhesion Kinase as a Modulator of Migration and Invasion and as a Potential Therapeutic Target in Chronic Lymphocytic Leukemia [PDF]

, 2022
Thomas A. Burley, Andrew Hesketh, Giselda Bucca, Emma Kennedy, Eleni E Ladikou, Benjamin P. Towler, Simon Mitchell, Colin P. Smith, Chris Fegan, Rosalynd Johnston, Andrea Pepper, Chris Pepper   +11 more
openalex   +1 more source

Development of a Synthetic Hydrogel to Foster Microvascularization of an Endometriosis Microphysiological System

Advanced Healthcare Materials, EarlyView.
ABSTRACT The ascent of novel alternative methods in drug development spotlights the dual needs for improved biological fidelity to in vivo, along with reproducibility, especially in regulatory applications. The need for pre‐clinical models of patient‐derived endometriosis lesions motivates the development of a vascularizable, completely synthetic ...
Lauren Pruett, Laura Bahlmann, Ryan Ogi, Angela Jiao, Priyatanu Roy, Matthew Johnson, David Trumper, Linda Griffith   +7 more
wiley   +1 more source

Nuclear Focal Adhesion Kinase [PDF]

Circulation Research, 2019
Sizhao Lu, Mary C.M. Weiser-Evans
openaire   +1 more source