Results 141 to 150 of about 84,022 (261)

Targeting focal adhesion kinase inhibits cell migration and non-angiogenic vascularization in malignant breast cancer. [PDF]

Breast Cancer
Masuyama M, Shimoda M, Seto I, Kikumori K, Abe K, Masunaga N, Mishima C, Tsukabe M, Yoshinami T, Sota Y, Miyake T, Tanei T, Shimazu K.   +12 more
europepmc   +1 more source

Nuclear Focal Adhesion Kinase [PDF]

Circulation Research, 2019
Sizhao Lu, Mary C.M. Weiser-Evans
openaire   +1 more source

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

Focal Adhesion Kinase Promotes Calcification of Vascular Smooth Muscle Cells via Regulation of Histone Deacetylase 4 and 5. [PDF]

Arterioscler Thromb Vasc Biol
Tian W, Singh K, Kajuluri LP, Lu J, Lee S, Roh K, Nicholson CJ, Jiang W, Barnes HJ, Sato T, Boerboom S, Ostrom K, Li RH, Birchenough C, Moore E, Tattersfield H, Sigurslid HH, Mahamdeh MS, Mosquera JV, Hodonsky CJ, Johnson AL, Chou EL, Nigwekar S, Lindsay ME, Bloch DB, Lino Cardenas CL, Ichinose F, Miller CL, Wein MN, Malhotra R.   +29 more
europepmc   +1 more source

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source

Recent advances in focal adhesion kinase (FAK)-targeting antitumor agents. [PDF]

RSC Adv
Zhu SK, Wu Q, Liu GX, Geng AQ, Wang PA.
europepmc   +1 more source

Aptamer‐Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis

Advanced Science, EarlyView.
This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai, Huan Yu, Zihan Ni, Kan Chen, I‐Chen Tsai, Zeyu Bao, Shuo Sun, Weichang Li, Yunhua Chen, Qiong Xu   +9 more
wiley   +1 more source

Context-specific targeting of focal adhesion kinase in brain tumors: lessons from glioblastoma and neurofibromatosis type 2-mutant meningioma. [PDF]

Front Oncol
Sagerer A, Eyüpoglu IY, Juratli TA, Cordes N.   +3 more
europepmc   +1 more source

GLS1 Orchestrates Exosome‐Mediated Tumor‐Endothelial Communication to Facilitate Angiogenesis

Advanced Science, EarlyView.
This study reveals a previously unappreciated, non‐metabolic function of GLS1 in the control of tumor angiogenesis via exosome‐mediated CAV1‐TNC signaling, indicating that therapeutic targeting of GLS1 may offer a dual benefit by simultaneously suppressing tumor metabolic activity and angiogenic processes in head and neck cancer. ABSTRACT Glutaminase 1
Jianqiang Yang, Zhenzhen Fu, Fanghui Chen, Soumya Vijaya Kumar, Fan Yang, Yaochao Zheng, Yunqi Li, Yao Yao, Nabil F. Saba, Yong Teng   +9 more
wiley   +1 more source

Focal adhesion kinase plays an essential role in Th17 cell differentiation by stimulating NF-κB signaling. [PDF]

Front Immunol
Kim HS, Lee JH, Sohn H, Lee WH, Kim GE, Lee W, Kim HR, Lee GR.   +7 more
europepmc   +1 more source