Results 261 to 270 of about 156,176 (352)

Abstract 115: A CD40 agonist potentiates the efficacy and immune-stimulatory capacity of chemotherapy in combination with a focal adhesion kinase inhibitor in a mouse model of pancreatic ductal adenocarcinoma

, 2019
Meredith L. Stone, Kathleen Graham, Daniel L. Aldridge, Kanika Jain, Xiaoqing Pan, Jonathan A. Pachter, Gregory L. Beatty   +6 more
openalex   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Focal Adhesion Kinase Intersects With the BRD4-MYC Axis and YAP1 to Drive Tumor Cell Growth, Phenotypic Plasticity, Stemness, and Metastatic Potential in Colorectal Cancer. [PDF]

Cancer Med
Han R, Shi J, Cheng K, Wang Z, Chen Y, Spellecy O, Faisal ASM, Aryal I, Chen J, Craven R, Thibault O, Baldwin L, Brewer LD, Erfani S, Wang C, Guo Z, Chen E, Yang B, Ueland F, Guo R, Yang X.   +20 more
europepmc   +1 more source

Table S3 from Co-targeting Phosphoinositide 3-Kinase and Focal Adhesion Kinase Pathways Inhibits Proliferation of NF2 Schwannoma Cells

Haley M. Hardin, Christine T. Dinh, Julianne Huegel, Alejandra M. Petrilli, Olena Bracho, Abdulrahman Allaf, Matthias A. Karajannis, Anthony J. Griswold, Michael E. Ivan, Jacques J. Morcos, Sakir H. Gultekin, Fred F. Telischi, Xue Zhong Liu, Cristina Fernández‐Valle   +13 more
openalex   +1 more source

The Focal Adhesion Kinase Suppresses Transformation-associated, Anchorage-independent Apoptosis in Human Breast Cancer Cells

, 2000
Li‐Hui Xu, Xihui Yang, Cynthia A. Bradham, David A. Brenner, Albert S. Baldwin, Rolf J. Craven, William G. Cance   +6 more
openalex   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Supplementary Table S2 from Development of Combination Strategies for Focal Adhesion Kinase Inhibition in Diffuse Gastric Cancer

Ke Peng, Feifei Zhang, Yichen Wang, Pranshu Sahgal, Tianxia Li, Jin Zhou, Xiaoyan Liang, Yanxi Zhang, Nilay S. Sethi, Tianshu Liu, Haisheng Zhang, Adam J. Bass   +11 more
openalex   +1 more source

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

Focal adhesion kinase promotes ribosome biogenesis to drive advanced thyroid cancer cell growth and survival. [PDF]

Front Oncol
Kellett MD, Sharma V, Sherlock ME, Pugazhenthi U, Rose MM, Joshi MU, Dzieciatkowska M, Nguyen V, Reigan P, Hansen KC, Kieft JS, Schweppe RE.   +11 more
europepmc   +1 more source

KSHV ‐ TK is a tyrosine kinase that disrupts focal adhesions and induces Rho‐mediated cell contraction

, 2014
Michael B. Gill, R D Turner, Philip G. Stevenson, Michael Way   +3 more
openalex   +2 more sources