Results 241 to 250 of about 156,176 (352)

Silencing profilin-1 inhibits gastric cancer progressionviaintegrin β1/focal adhesion kinase pathway modulation

, 2015
Yajun Cheng
openalex   +2 more sources

Focal Adhesion Kinase–Mediated Activation of Glycogen Synthase Kinase 3β Regulates IL-33 Receptor Internalization and IL-33 Signaling [PDF]

, 2014
Jing Zhao, Jianxin Wei, Rachel K. Bowser, Russell S. Traister, Ming-Hui Fan, Yutong Zhao   +5 more
openalex   +1 more source

ETV4 Promotes Colorectal Cancer Progression by Reprogramming Asparagine Metabolism to Remodel the Stromal Microenvironment

Advanced Science, EarlyView.
ETV4 coordinates a dual transcriptional program by upregulating MET and asparagine synthetase (ASNS). The resulting asparagine (Asn) secretion acts as a metabolic signal, reprogramming hepatic stellate cells (HSCs) and primary cancer‐associated fibroblasts (CAFs) toward an inflammatory phenotype. These activated stromal cells release HGF to sustain the
Dujiang Fu, Meijia Zhang, Maoping Cai, Miao Wang, Ziao Huang, Zesheng Lin, Yixin Liu, Wang Qian, Guopeng Chen, Yuxing Liang, Dongyi Wei, Jing xie, Picheng Yan, Yuanyuan Qu, Yongchang Wei   +14 more
wiley   +1 more source

Focal adhesion kinase inhibition induces membrane accumulation of aquaporin-2 in renal epithelial cells by actin depolymerization and endocytosis inhibition. [PDF]

Am J Physiol Renal Physiol
Tchakal-Mesbahi A, He J, Zhu S, Huang M, Fukushima K, Bouley R, Brown D, Lu HAJ.   +7 more
europepmc   +1 more source

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Focal adhesion kinase (FAK): emerging target for drug-resistant malignant tumors. [PDF]

Mol Biol Rep
Aakriti J, Vithalkar MP, Maity S, Baby K, Nagareddy PR, Nayak Y.   +5 more
europepmc   +1 more source

Focal adhesion kinase autophosphorylation inhibition decreases colon cancer cell growth and enhances the efficacy of chemotherapy [PDF]

, 2013
Melissa Heffler, Vita Golubovskaya, Kelli M. Bullard Dunn, William G. Cance   +3 more
openalex   +1 more source

Mitochondrial CircRNA CircMT‐RNR2 Safeguards Antioxidant Defense to Support Fibroblast Functions in Wound Repair

Advanced Science, EarlyView.
CircMT‐RNR2 promotes wound healing by enhancing fibroblast proliferation, migration, contraction, and extracellular matrix (ECM) production. It sustains mitochondrial redox balance by stabilizing the antioxidant protein PRDX3, thereby reducing ROS‐induced damage. In diabetic foot ulcers, hypoxia, hyperglycemia, and reduced FGF2 and EGF expression lower
Guanglin Niu, Jennifer Geara, Yongjian Chen, Lihua Luo, Yanwei Xiao, Zhuang Liu, Margaux Gaborieau, Ling Pan, Edmund Loh, Dongqing Li, Pehr Sommar, Aoxue Wang, Xiaowei Zheng, Ning Xu Landén   +13 more
wiley   +1 more source

Focal adhesion kinase/Src family kinase axis-mediated tyrosine phosphorylation of metabolic enzymes facilitates tumor metastasis. [PDF]

Signal Transduct Target Ther
Chen J, Zhang J, Zhu Y, Zhu Y, Pang J, Wu Q, Wang Y, Zhan Q.   +7 more
europepmc   +1 more source

The effect of focal adhesion kinase gene silencing on 5‐fluorouracil chemosensitivity involves an Akt/NF‐κB signaling pathway in colorectal carcinomas [PDF]

, 2009
Yuying Chen, Zhanxiang Wang, Pingan Chang, Liuxin Xiang, Feng Pan, Jianjun Li, Jinyan Jiang, Lan Zou, Yang Li, Zhiheng Bian, Houjie Liang   +10 more
openalex   +1 more source