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Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase
Nature Cell Biology, 2005Imaging studies implicate microtubule targeting of focal adhesions in focal adhesion disassembly, although the molecular mechanism is unknown. Here, we develop a model system of focal adhesion disassembly based on the finding that microtubule regrowth after nocodazole washout induces disassembly of focal adhesions, and that this disassembly occurs ...
Ellen J, Ezratty +2 more
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Focal adhesion kinase in cancer
Emerging Therapeutic Targets, 2000Focal adhesion kinase (FAK) has received much attention as a transducer of integrin-mediated signals. FAK becomes autophosphorylated on tyrosine 397 (Y397) in response to cell adhesion to the extracellular matrix (ECM) and in response to certain growth factors.
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Focal adhesion kinase in keratinocyte adhesion
Journal of the American College of Surgeons, 2000Lawrence T Kim +2 more
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Structural basis of Focal Adhesion Kinase activation on lipid membranes
EMBO Journal, 2020OSCAR Llorca +2 more
exaly
Spatiotemporal dynamics of focal adhesion kinase
Nature Chemical Biology, 2023openaire +2 more sources
Focal adhesion kinase inhibitors in the treatment of solid tumors: Preclinical and clinical evidence
Drug Discovery Today, 2022Martin Lavecchia, Ignacio Leon
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