Results 221 to 230 of about 84,022 (261)

Focal adhesion kinase and associated proteins

Current Opinion in Cell Biology, 1994
Focal adhesion kinase (pp125FAK), a protein tyrosine kinase, has recently been suggested to regulate aspects of signalling induced by integrins and by certain growth factor and hormone receptors. New studies indicate that the domains of pp125FAK regulate its interactions with integrin subunits, other protein tyrosine kinases, and the focal adhesion ...
Michael D Schaller, J Thomas Parsons, J T Parsons   +2 more
exaly   +3 more sources

Focal adhesion kinase in cancer

Frontiers in Bioscience, 2003
Focal adhesion kinase (FAK) is a non-receptor cytoplasmic tyrosine kinase that transmits signals important in modulating several cell functions, including proliferation, migration, and survival. Several different types of malignant tumors have been reported to express elevated levels of FAK protein in vivo, potentially pointing to a role for FAK in ...
Timothy P, Hecker, Candece L, Gladson
openaire   +2 more sources

Focal adhesion kinase

The International Journal of Biochemistry & Cell Biology, 1997
Focal adhesion kinase (FAK) is a member of a growing family of non-receptor protein tyrosine kinases. Though originally identified as a putative substrate for the oncogenic tyrosine kinase pp60v-src, it is now well-established that FAK tyrosine phosphorylation is induced by adhesion of cell surface integrins to extracellular matrix and by a variety of ...
openaire   +2 more sources

Signaling through focal adhesion kinase

BioEssays, 1997
AbstractFocal adhesion kinase (FAK) is a nonreceptor protein‐tyrosine kinase implicated in controlling cellular responses to the engagement of cell‐surface integrins, including cell spreading and migration, survival and proliferation. Aberrant FAK signaling may contribute to the process of cell transformation by certain oncoproteins, including v‐Src ...
S K, Hanks, T R, Polte
openaire   +2 more sources

Focal Adhesion Kinase in Neuritogenesis

2007
The transduction of extracellular signals through adhesion and guidance receptors into cytoskeleton reorganization underlies axon outgrowth and pathfinding decisions. The cytoplasmic protein tyrosine kinase focal adhesion kinase (FAK), a central regulator of cell motility phenomena during morphogenesis, is highly expressed in the developing nervous ...
Bonanomi D., Valtorta F.
openaire   +1 more source

Focal adhesion kinase: Structure and signalling

Journal of Cell Science, 1994
Studies on the attachment and spreading of cells in culture have provided valuable insights into the mechanisms by which cells transmit information from the outside to the inside of the cell. This brief review considers recent information on the role of focal adhesion-associated protein tyrosine kinases in integrin-regulated cell signalling.
J T, Parsons, M D, Schaller, J, Hildebrand, T H, Leu, A, Richardson, C, Otey   +5 more
openaire   +2 more sources

Mechanisms of Focal Adhesion Kinase Regulation

Current Cancer Drug Targets, 2005
Focal adhesion kinase (FAK) is a tyrosine kinase whose phosphorylation state and activity is tightly linked to cell adhesion to the extracellular matrix through integrin receptors. FAK's regulation by adhesion places it in a key position to be able to influence cellular events that are either dependent on cell adhesion like cell proliferation and ...
Lee Ann, Cohen, Jun-Lin, Guan
openaire   +2 more sources

Focal adhesion kinase—An emerging viable target in cancer and development of focal adhesion kinase inhibitors

Chemical Biology & Drug Design, 2020
AbstractFocal adhesion kinase (FAK) is a non‐receptor tyrosine kinase located at the extracellular matrix cell adhesion site. This kinase mediates downstream signalling cascades on the cell‐extracellular matrix of integrins, cytokine receptors, growth factor receptors and G‐protein‐coupled receptors. Several studies have suggested the importance of FAK
Akshita Chauhan, Tabassum Khan
openaire   +2 more sources

Expression of focal adhesion kinase and phosphorylated focal adhesion kinase in squamous cell carcinoma of the larynx

The Laryngoscope, 2003
AbstractObjectives: Focal adhesion kinase (FAK) is overexpressed in a variety of human cancers including those derived from the oral cavity. The purpose of this work is to determine the expression patterns of FAK and its activated form, FAK pY397, in squamous cell carcinoma of the larynx and to correlate FAK expression with tumor differentiation and ...
Michael S, Aronsohn, Heather M, Brown, Garrett, Hauptman, Lori J, Kornberg   +3 more
openaire   +2 more sources

Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase

Nature Cell Biology, 2005
Imaging studies implicate microtubule targeting of focal adhesions in focal adhesion disassembly, although the molecular mechanism is unknown. Here, we develop a model system of focal adhesion disassembly based on the finding that microtubule regrowth after nocodazole washout induces disassembly of focal adhesions, and that this disassembly occurs ...
Ellen J, Ezratty, Michael A, Partridge, Gregg G, Gundersen   +2 more
openaire   +2 more sources