Results 221 to 230 of about 1,221,131 (252)

Focal adhesion kinase signaling - tumor vulnerabilities and clinical opportunities.

J Cell Sci
Schlaepfer DD, Ojalill M, Stupack DG.
europepmc   +1 more source

Focal adhesion kinase regulates tendon cell mechanoresponse and physiological tendon development. [PDF]

FASEB J
Leahy TP, Chenna SS, Soslowsky LJ, Dyment NA.   +3 more
europepmc   +1 more source

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis

Advanced Science, EarlyView.
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang, Siteng Li, Wenzhong Chen, Qingcheng Song, Haiyue Zhao, Peng Wang, Yiran Zhang, Wenquan Liang, Shaowei Zheng, Juan Wang, Wei Chen, Yanbin Zhu, Yingze Zhang   +12 more
wiley   +1 more source

Combined inhibition of focal adhesion kinase and RAF/MEK elicits synergistic inhibition of melanoma growth and reduces metastases. [PDF]

Cell Rep Med
Almazan J, Turapov T, Kircher DA, Stanley KA, Culver K, Medellin AP, Field MN, Parkman GL, Colman H, Coma S, Pachter JA, Holmen SL.   +11 more
europepmc   +1 more source

Unravelling the Distinct Phenotype and Mechanosensitive Properties of Different Tendon Cell Populations

Advanced Science, EarlyView.
Tendon interfascicular and fascicular matrix cells are isolated and cultured, revealing distinct phenotypes and mechanosensitive responses. Interfascicular matrix cells exhibit marked stiffness‐dependent phenotypic plasticity, whereas fascicular matrix cells remain comparatively stable.
S. E. Grossemy, D. E. Zamboulis, N. S. Khatib, M. R. Fazal, C. C. Gains, A. Giannopoulos, T. Hopkins, C. Bevan, Y. Aggarwal, M. M. Knight, H. R. C. Screen   +10 more
wiley   +1 more source

Focal adhesion kinase as a new player in the biology of onco-hematological diseases: the starting evidence. [PDF]

Front Oncol
Capasso G, Mouawad N, Castronuovo M, Ruggeri E, Visentin A, Trentin L, Frezzato F.   +6 more
europepmc   +1 more source

COL8A1 overexpression promotes glioma cell growth by activating focal adhesion kinase signaling cascade. [PDF]

NPJ Precis Oncol
Qian J, Xing H, Wang Y, Li C, Chen H, Rong J, Qian C.   +6 more
europepmc   +1 more source

<i>O</i>-GlcNAcylation of Focal Adhesion Kinase Regulates Cell Adhesion, Migration, and Proliferation via the FAK/AKT Pathway. [PDF]

Biomolecules
Zhang Z, Isaji T, Oyama Y, Liu J, Xu Z, Sun Y, Fukuda T, Lu H, Gu J.   +8 more
europepmc   +1 more source

Focal Adhesion Kinase and Colony Stimulating Factors: Intestinal Homeostasis and Innate Immunity Crosstalk. [PDF]

Cells
Brown ND, Vomhof-DeKrey EE.
europepmc   +1 more source

Cytoarchitecture of Breast Cancer Cells under Diabetic Conditions: Role of Regulatory Kinases-Rho Kinase and Focal Adhesion Kinase. [PDF]

Cancers (Basel)
Dutta D, Ziemke M, Sindelar P, Vargas H, Lim JY, Chandra S.   +5 more
europepmc   +1 more source