Results 111 to 120 of about 1,278,750 (244)

A luciferase fragment complementation assay to detect focal adhesion kinase (FAK) signaling events. [PDF]

Heliyon, 2023
Estep JA, Sun LO, Riccomagno MM.
europepmc   +1 more source

Opposing roles of acid phosphatase 1 (ACP1) and ACP3 in prostate cancer progression

BJU International, EarlyView.
Objectives To evaluate the roles of intracellular acid phosphatase 1 (ACP1) and ACP3 expression as biomarkers of prostate cancer progression through a systematic review and meta‐analysis assessing associations with disease presence, tumour aggressiveness, and patient prognosis.
Alessandra V. de S. Faria, Carmen V. Ferreira‐Halder, Maikel P. Peppelenbosch, Gwenny M. Fuhler   +3 more
wiley   +1 more source

Rôle de la protéine FAK (Focal Adhésion Kinase) dans les mécanismes d'invasion cellulaire [PDF]

, 2012
Cette thèse traite du rôle de la protéine FAK (Focal Adhésion Kinase) dans les mécanismes d'invasion cellulaire.This thesis is about the role of the protein FAK (Focal Adhesion Kinase) in the cellular mechanisms of invasion.STRASBOURG-Bib.electronique ...
KOLLI, Kaouther, RONDE, Philippe
core  

Targeted Focal Adhesion Kinase Activation in Cardiomyocytes Protects the Heart From Ischemia/Reperfusion Injury [PDF]

, 2012
We previously reported that cardiac-restricted deletion of focal adhesion kinase (FAK) exacerbated myocyte death following ischemia/reperfusion (I/R). Here we interrogated whether targeted elevation of myocardial FAK activity could protect the heart from
DiMichele, L. A., Hakim, Z. S., Cheng, Zhaokang, Rojas, M., Mack, C. P., Mack, Christopher P, Cheng, Z., Hakim, Zeenat S, Rojas, Mauricio, DiMichele, Laura A, Taylor, Joan M, Taylor, J. M.   +11 more
core   +1 more source

PF573,228 inhibits vascular tumor cell growth, migration as well as angiogenesis, induces apoptosis and abrogates PRAS40 and S6RP phosphorylation

Acta Pharmaceutica, 2016
PF573,228 is a compound that targets focal adhesion kinase (FAK), a non-receptor protein kinase, which is over-expressed in various tumors. The aim of this study was to evaluate the effects of PF573,228 on the cells derived from mouse vascular tumors ...
Mabeta Peace
doaj   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

An Inhibitory Role for FAK in Regulating Proliferation: A Link Between Limited Adhesion and RhoA-ROCK Signaling [PDF]

, 2006
Focal adhesion kinase (FAK) transduces cell adhesion to the extracellular matrix into proliferative signals. We show that FAK overexpression induced proliferation in endothelial cells, which are normally growth arrested by limited adhesion. Interestingly,
Lin Gao, Chen, Christopher S., Lewis H. Romer, Raghavan, Srivatsan, Wendy F. Liu, Pirone, Dana M, Dana M. Pirone, Lemmon, Christopher A, Christopher A. Lemmon, Liu, Wendy F, Ruiz, Sami Alom, Srivatsan Raghavan, Romer, Lewis H, Sami Alom Ruiz, Gao, Lin, Christopher S. Chen   +15 more
core   +1 more source

A novel drug-like water-soluble small molecule Focal Adhesion Kinase (FAK) activator promotes intestinal mucosal healing. [PDF]

Curr Res Pharmacol Drug Discov, 2023
Wang Q, Gallardo-Macias R, Vomhof-DeKrey EE, Gupta R, Golovko SA, Golovko MY, Oncel S, Gurvich VJ, Basson MD.   +8 more
europepmc   +1 more source

CD93—An emerging vascular target in cancer therapy

British Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira, Stefano Barbera, Roberta Lugano, Anna Dimberg   +3 more
wiley   +1 more source

The Biological Basis of the Merlin CP‐GEP Assay: Integrin Signaling and Early Metastatic Competence in Cutaneous Melanoma

International Journal of Dermatology, EarlyView.
Merlin CP‐GEP integrates mechanistic insights into a clinically actionable assay to predict SLN metastasis risk and inform personalized management of cutaneous melanoma. ABSTRACT The recent inclusion of the Merlin clinicopathologic–gene expression profile (CP‐GEP) assay in the National Comprehensive Cancer Network (NCCN) Melanoma Guidelines represents ...
Frank Z. Jing, Alexander Meves
wiley   +1 more source