Results 121 to 130 of about 1,278,750 (244)

Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer

, 2013
We previously found focal adhesion kinase (FAK) inhibition sensitizes ovarian cancer to taxanes; however, the mechanisms are not well ...
Wu, Sherry Y., Pecot, Chad V., Lu, Chunhua, Jennings, Nicholas B., Dalton, Heather J., Huang, Jie, Sood, Anil K., Miyake, Takahito, Huang, Jianfei, Pradeep, Sunila, Wen, Yunfei, Kang, Yu, Zand, Behrouz, Hu, Wei, Liu, Jinsong, Taylor, Morgan, Liu, Tao, Rupaimoole, Rajesha, Ivan, Cristina   +18 more
core   +1 more source

Focal adhesion kinase signaling in cardiac hypertrophy and failure

Brazilian Journal of Medical and Biological Research, 2009
Focal adhesion kinase (FAK) is a broadly expressed tyrosine kinase implicated in cellular functions such as migration, growth and survival. Emerging data support a role for FAK in cardiac development, reactive hypertrophy and failure.
K.G. Franchini, C.F.M.Z. Clemente, T.M. Marin   +2 more
doaj  

Focal adhesion kinase (FAK) promotes cholangiocarcinoma development and progression via YAP activation. [PDF]

J Hepatol, 2021
Song X, Xu H, Wang P, Wang J, Affo S, Wang H, Xu M, Liang B, Che L, Qiu W, Schwabe RF, Chang TT, Vogl M, Pes GM, Ribback S, Evert M, Chen X, Calvisi DF.   +17 more
europepmc   +1 more source

Hyaluronic Acid Modulates IL1β‐Induced Cytokine Profile of Gingival Mesenchymal Stem Cells

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim Hyaluronic acid (HA) possesses anti‐inflammatory properties critical for periodontal wound healing. In this study, we aimed to evaluate the role of cross‐linked high‐molecular‐weight (HMW) HA on cytokine mRNA expression, cell viability and migration in IL‐1β‐stimulated gingival mesenchymal stem cells (gMSCs).
Sema S. Hakki, Darko Božić, Anton Sculean, Serife Buket Bozkurt   +3 more
wiley   +1 more source

Fibrinogen activates focal adhesion kinase (FAK) promoting colorectal adenocarcinoma growth. [PDF]

J Thromb Haemost, 2021
Sharma BK, Mureb D, Murab S, Rosenfeldt L, Francisco B, Cantrell R, Karns R, Romick-Rosendale L, Watanabe-Chailland M, Mast EM, Flick MJ, Whitlock PW, Palumbo JS.   +12 more
europepmc   +1 more source

Impact of systemic diseases on periodontal remodeling: Mechanisms, mediators, and clinical relevance

Periodontology 2000, EarlyView.
Abstract Background Periodontal remodeling is a continuous, adaptive process essential for maintaining the structural and functional integrity of periodontal tissues. While external factors such as bacterial biofilm, excessive forces, and poor oral hygiene are recognized triggers of periodontal pathologies, they do not fully explain their persistent ...
Michael Wolf, Ulrike Schulze‐Späte, Thomas Van Dyke, Stefan Wolfart, Thomas Dietrich, Alberto Ortiz, Zhuojun Wu, Joachim Jankowski   +7 more
wiley   +1 more source

Focal adhesion kinase (FAK) [PDF]

Science-Business eXchange, 2012
openaire   +3 more sources

Periodontitis and metabolic dysfunction‐associated steatotic liver disease

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis is a chronic inflammatory disease with systemic effects that extend beyond the oral cavity and contribute to systemic immune and metabolic dysregulation. Chronic liver diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive phenotypes, have emerged as major global ...
Rafael Scaf de Molon, Erica Dorigatti de Avila, Davi da Silva Barbirato, Mariana Fampa Fogacci, Jamil Awad Shibli, Anton Sculean, Alpdogan Kantarci   +6 more
wiley   +1 more source

Putting the brakes on muscle growth: Myostatin as regulator of disuse atrophy

Experimental Physiology, EarlyView.
Abstract Skeletal muscle is a highly plastic tissue that rapidly adapts to changes in mechanical loading and metabolic activity. Periods of inactivity, including bed rest, limb immobilization or microgravity, induce a pronounced loss of muscle mass and function.
Derk H. C. Nieuwenhuijsen, Moritz Eggelbusch, Rob C. I. Wüst   +2 more
wiley   +1 more source

Serine-Threonine Kinase Receptor Associate Protein (STRAP) confers an aggressive phenotype in neuroblastoma via regulation of Focal Adhesion Kinase (FAK). [PDF]

J Pediatr Surg, 2022
Bownes LV, Marayati R, Quinn CH, Hutchins SC, Stewart JE, Anderson JC, Willey CD, Datta PK, Beierle EA.   +8 more
europepmc   +1 more source