Results 141 to 150 of about 1,278,750 (244)

Focal adhesion kinase (FAK) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling

Advanced Science, Volume 13, Issue 61, 3 November 2026.
ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.
Lei Gao, Qinying Han, Yunpeng Wang, Xuemei Li, Bofang Wang, Baohong Gu, Weidong Li, Lin Xiang, Ying Zhang, Hao Chen   +9 more
wiley   +1 more source

Focal adhesion kinase (FAK) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

Nanofabricated Biomaterials Model Tumor Extracellular Matrix Topography

Advanced NanoBiomed Research, Volume 6, Issue 11, November 2026.
The unique structure and composition of the tumor microenvironment and its associated extracellular matrix (ECM) exert profound effects on cancer cell behavior that are difficult to model in vitro. This perspective discusses the utility of nanofabricated biosubstrates, such as the novel collagen‐coated nanogrooved array, for recapitulating the ...
Vic Zamloot, JinSeok Park
wiley   +1 more source

Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK)

, 2016
Analogues structurally related to anaplastic lymphoma kinase (ALK) inhibitor 1 were optimized for metabolic stability. The results from this endeavor not only led to improved metabolic stability, pharmacokinetic parameters, and in vitro activity against ...
Joseph G. Lisko (2080012), Nathan Anderson (540525), Mark S. Albom (2080009), Jason Wagner (2941464), Jay Friedman (32982), Lisa D. Aimone (2167555), Elizabeth Bruckheimer (2941461), Mark A. Ator (2080039), Keith S. Learn (2941467), Eugen F. Mesaros (2125468), Zeqi Huang (2125459), Weihua Wan (2080021), Bruce D. Dorsey (2080042), Gregory R. Ott (2080024), Matthew Curry (2941455), Sandra V. Fernandez (2941458), Matthew R. Quail (2125474), Lihui Lu (2080033), Arup K. Ghose (1265196), Thelma S. Angeles (2080027), Diane E. Gingrich (2080018), Mangeng Cheng (411194), Pawel Dobrzanski (2941452), Bruce A. Ruggeri (2167558), Kevin Wells-Knecht (2080036)   +24 more
core   +1 more source

Using QCM‐D for Real‐Time Analysis of Cell Adhesion Dynamics at Biointerfaces

Advanced Materials Interfaces
Efficient cell adhesion is crucial for host tissue attachment and improving implant integration. This study aims at investigating adhesion of human gingival fibroblasts to functionalized biomaterial surfaces using quartz crystal microbalance with ...
Agnes Rogala, Hanna Tiainen, Daria Zaytseva‐Zotova   +2 more
doaj   +1 more source

Focal adhesion kinase (FAK) [PDF]

Science-Business eXchange, 2011
openaire   +1 more source

Mechanisms of Tumor Cell Invasion: Insights From the Perspective of Epithelial‐to‐Mesenchymal Transition

Cell Biochemistry and Function, Volume 44, Issue 11, November 2026.
ABSTRACT Tumor invasion implies aberrantly increased cell motility, and is the first step of the cascade of events culminating in the development of distant metastases. The emergence of migratory capacity in epithelial carcinomas, consisting essentially of stationary cells, is linked to the activation of the epithelial‐to‐mesenchymal transition (EMT ...
Marcello Guarino
wiley   +1 more source

Focal Adhesion Kinase (FAK) Binds RET Kinase via Its FERM Domain, Priming a Direct and Reciprocal RET-FAK Transactivation Mechanism

, 2010
Whether RET is able to directly phosphorylate and activate downstream targets independently of the binding of proteins that contain Src homology 2 or phosphotyrosine binding domains and whether mechanisms in trans by cytoplasmic kinases can modulate RET ...
Isacke, Clare M., Phillip Knowles, Iván Plaza-Menacho, Neil Q. McDonald, Luca Mologni, Anthony I. Magee, Robert M.W. Hofstra, Plaza-Menacho, Ivan, Mologni, Luca, Magee, Anthony I., Morandi, Andrea, Hatakeyama, Shinji, Knowles, Phillip, Boender, Piet, Piet Boender, Gambacorti-Passerini, Carlo, Hofstra, Robert M. W., Carlo Gambacorti-Passerini, Andrea Morandi, Clare M. Isacke, Piet, Boender, McDonald, Neil Q.   +21 more
core   +1 more source

Combined inhibition of focal adhesion kinase and RAF/MEK elicits synergistic inhibition of melanoma growth and reduces metastases

Cell Reports Medicine
Summary: This study addresses the urgent need for effective therapies for patients with brain metastases from cutaneous melanoma, a major cause of treatment failure despite recent therapeutic advances.
Jared Almazan, Tursun Turapov, David A. Kircher, Karly A. Stanley, Katie Culver, A. Paulina Medellin, MiKaela N. Field, Gennie L. Parkman, Howard Colman, Silvia Coma, Jonathan A. Pachter, Sheri L. Holmen   +11 more
doaj   +1 more source