Results 131 to 140 of about 1,278,750 (244)

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Focal Adhesion Kinase: Potential Cancer Inhibitors

, 2012
Focal Adhesion Kinase (FAK) is a non-receptor protein kinase that plays a critical role in cell signaling, and the regulation of many cellular processes.
Globerson, Jeffrey
core  

Vascular smooth muscle cell mechanotransduction: Pathways, phenotypes and emerging technologies

The Journal of Physiology, EarlyView.
Abstract figure legend Vascular smooth muscle cells are exposed to mechanical stimuli from the blood flow and the extracellular matrix. The cells sense the signals from cyclic stretch, shear stress, hydrostatic pressure and matrix stiffness through specialized mechanosensors, such as mechanosensitive ion channels or cell surface receptors including ...
Nivethitha Kota Lakshminaraasimulu, Rachel E. A. Smyth, Aishwarya Prakash, Thomas Iskratsch   +3 more
wiley   +1 more source

Focal Adhesion Kinase (FAK) Inhibition Synergizes with KRAS G12C Inhibitors in Treating Cancer through the Regulation of the FAK-YAP Signaling. [PDF]

Adv Sci (Weinh), 2021
Zhang B, Zhang Y, Zhang J, Liu P, Jiao B, Wang Z, Ren R.   +6 more
europepmc   +1 more source

Cancer‐associated fibroblast heterogeneity across solid and haematological malignancies: Lessons from colorectal cancer and multiple myeloma

The Journal of Physiology, EarlyView.
Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo, Haoyan Han, Michael O'Dwyer, Eileen Reidy, Aideen E. Ryan   +4 more
wiley   +1 more source

Structural and mechanistic insights into mechanoactivation of focal adhesion kinase

, 2019
Focal adhesion kinase (FAK) is a key signaling molecule regulating cell adhesion, migration, and survival. FAK localizes into focal adhesion complexes formed at the cytoplasmic side of cell attachment to the ECM and is activated after force generation ...
Durner Ellis, Milles Lukas Frederik, Baumann Fabian, Lietha Daniel, Pippig Diana Angela, Bauer Magnus Sebastian, Graeter Frauke, Gaub Hermann Eduard, Daday Csaba, Jobst Markus Andreas, Mercadante D, Redondo Pilar   +11 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, Volume 20, Issue 11, Page 2569-2583, November 2026.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Inhibiting focal adhesion kinase (FAK) blocks IL-4 induced VCAM-1 expression and eosinophil recruitment in vitro and in vivo

, 2018
Leukocyte recruitment plays a critical role during both normal inflammation and chronic inflammatory diseases, and ongoing studies endeavor to better understand the complexities of this process.
Pina Colarusso, Björn Petri, James J Lee, Katarzyna M Wojcik, Gurpreet K Aulakh, Kamala D Patel   +5 more
core   +1 more source

Research progress of PYK2 in digestive system diseases

Frontiers in Immunology
Belonging to the focal adhesion kinase (FAK) family, proline-rich tyrosine kinase 2 (PYK2) is a non-receptor tyrosine kinase, has become a focal point in cancer research owing to its essential participation in the formation and dissemination of tumors ...
Yiyao Duan, Yiyao Duan, Mingzhu Xie, Hui Wang, Hui Wang, Sijing Chen, Sijing Chen, Jun Hu, Xujia Chen, Xujia Chen, Hong Ping Jia, Hong Ping Jia, Ningyan Zhang, Ningyan Zhang, Ling Peng, Ling Peng, Xiang Li, Hameed Ullah Khan, Hameed Ullah Khan, Die Hu, Rong Qin, Rong Qin   +21 more
doaj   +1 more source

Focal Adhesion Kinase (FAK)-Hippo/YAP transduction signaling mediates the stimulatory effects exerted by S100A8/A9-RAGE system in triple-negative breast cancer (TNBC). [PDF]

J Exp Clin Cancer Res, 2022
Rigiracciolo DC, Nohata N, Lappano R, Cirillo F, Talia M, Adame-Garcia SR, Arang N, Lubrano S, De Francesco EM, Belfiore A, Gutkind JS, Maggiolini M.   +11 more
europepmc   +1 more source