Results 151 to 160 of about 1,278,750 (244)

Integrin αvβ3 Engagement Regulates Glucose Metabolism and Migration through Focal Adhesion Kinase (FAK) and Protein Arginine Methyltransferase 5 (PRMT5) in Glioblastoma Cells. [PDF]

Cancers (Basel), 2021
Che P, Yu L, Friedman GK, Wang M, Ke X, Wang H, Zhang W, Nabors B, Ding Q, Han X.   +9 more
europepmc   +1 more source

Focal adhesion kinase (FAK) [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

Colonic Barrier Dysfunction and Inflammation Induced by Nano‐/Micro‐Plastics Fibers in Mice via the FAK/NF‐κB/iNOS and TLR4/NF‐κB/iNOS Pathways

Journal of Applied Toxicology, Volume 46, Issue 11, Page 4144-4159, November 2026.
ABSTRACT As emerging environmental contaminants, nano‐ and micro‐plastics (NMPs) have drawn increasing research attention due to potential hazards to organisms. Particle shape is a key factor influencing the toxic effects of NMPs, and NMPs of different shapes cause varying degrees of tissue damage. We investigated the specific mechanisms of polystyrene
Yuting Li, Shibo Bao, Puyang Huang, Jiahui Wang, Hongfeng Li, Yahong Liu, Kai Wang, Jianjun Du, Lingjun Yan, Guowei Pan, Wei Sun   +10 more
wiley   +1 more source

Development of a high-throughput TR-FRET assay to identify inhibitors of the FAK-paxillin protein-protein interaction

SLAS Discovery
Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase and scaffolding protein that is primarily regulated by integrin signaling. FAK signaling increases cell motility in both normal and cancer cells, and FAK is often overexpressed and/or ...
Rukayat Aromokeye, Martha Ackerman-Berrier, Rosa del Carmen Araujo, Maria Lambousis, Savio Cardoza, L. Charlie Chen, Matthew E. Kaplan, Haining Zhu, Christopher Penton, Celina Zerbinatti, Gregory R.J. Thatcher, Timothy Marlowe   +11 more
doaj   +1 more source

Hydrocalumite‐Like Material Induces Early Osteogenic Priming and ECM Remodeling Without Effective Mineralization in Preosteoblasts

Journal of Biomedical Materials Research Part A, Volume 114, Issue 11, November 2026.
ABSTRACT Hydrocalumite‐like phases, belonging to the layered double hydroxide family, are potential biomaterials for bone repair; however, their cellular effects remain incompletely understood. Here, we evaluated a hydrocalumite‐like material of composition [Ca2Al(OH)₆]Cl·nH2O (abbreviated Ca2Al–Cl) in preosteoblastic MC3T3‐E1 cells, assessing ...
C. J. da Costa Fernandes, G. S. de Almeida, M. Pires Figueiredo, V. R. L. Constantino, W. F. Zambuzzi   +4 more
wiley   +1 more source

The Efferocytosis‐Driven Macrophage Polarization: A Concerto in the Tumor Immunosuppressive Microenvironment

MedComm, Volume 7, Issue 11, November 2026.
Efferocytosis is a key process for macrophages to clear apoptotic cells, which undergoes the “ Find Me” chemotaxis signal stage, the “eat me” phagocytosis recognition stage and the “digest me” digestion stage in turn. During the aforementioned three stages, various signaling molecules released by apoptotic cells can promote the phenotypic polarization ...
Qiuping Chen, Chunzhi Wu, Changquan Huang, Hang Zhou   +3 more
wiley   +1 more source

Focal adhesion kinase and cancer [PDF]

, 2009
Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that resides at the sites of integrin clustering, known as focal adhesions. The FAK protein has a molecular mass of 125kDa and is encoded by the FAK gene located on human chromosome 8q24 ...
Kweh, Frederick A., Cance, William G., Golubovskaya1, Vita M.   +2 more
core  

Differential Regulation of Pyk2 and Focal Adhesion Kinase (FAK) [PDF]

Journal of Biological Chemistry, 1998
Chuanhai Zheng, Zheng Xing, Z. Christine Bian, Chunmei Guo, Aysegul Akbay, Laurie Warner, Jun-Lin Guan   +6 more
openaire   +1 more source

The PIEZO1/CISD1/IP3R Mechanotransduction Axis Drives Macrophage Mitochondrial Dysfunction and Inflammatory Activation in Pulmonary Fibrosis

MedComm, Volume 7, Issue 11, November 2026.
In the pulmonary fibrotic microenvironment, mechanical signals activate PIEZO1 to mediate Ca2+ entry into macrophages. Increased CISD1/IP3R activity promotes Ca2+ transfer from the endoplasmic reticulum to mitochondria, leading to mitochondrial Ca2+ overload and opening of the mitochondrial permeability transition pore (MPTP). Consequently, macrophages
Yungeng Wei, Chao Xie, Xiangsheng Yang, Xiao Xiao Tang   +3 more
wiley   +1 more source

Focal adhesion kinase (FAK); Src [PDF]

Science-Business eXchange, 2011
openaire   +1 more source