Results 161 to 170 of about 1,278,750 (244)

[The characteristics of focal adhesion kinase (FAK) and its role in carcinogenesis].

Postepy higieny i medycyny doswiadczalnej (Online), 2007
Focal adhesion kinase (FAK) is a 125-kDa cytoplasmic tyrosine kinase located in cells which create attachments with the extracellular matrix (ECM) or with other cells. The primary function of FAK is to transmit the signal coming from the integrine receptor, participating in adhesion, to the intracellular protein cascade.
Ewa, Totoń, Maria, Rybczyńska
openaire   +1 more source

Atherosclerosis: From Pathogenesis to Therapeutic Interventions

MedComm, Volume 7, Issue 11, November 2026.
The diagram outlines the core mechanisms driving atherosclerosis, including endothelial dysfunction, inflammatory responses, phenotypic switching of smooth muscle cells, and the gut–vascular axis. It also presents the corresponding therapeutic approaches now under development, such as gene therapies, immunotherapies, and nanotechnology platforms ...
Enge Zhou, Chenxi Zhan, Yuting Li, Yi Zeng, Renfei Luo, Xin Ouyang, Shixing Liu, Renqiang Yang, Nianlong Yan, Long Jiang   +9 more
wiley   +1 more source

Tendinopathy: Types, Epidemiology, Molecular Mechanisms, and Future Precision‐Oriented Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
This review presents tendinopathy as a heterogeneous disorder driven by dynamic interactions among mechanical sensing, inflammation, angiogenesis and innervation, and extracellular matrix remodeling. Integrating clinical phenotypes with imaging, biomarkers, and multi‐omics may enable molecular subtyping and mechanism‐guided interventions, advancing ...
Yang Wu, Junyi Long, Meng Yang, Hongjie Huang, Jianquan Wang   +4 more
wiley   +1 more source

Focal Adhesion Kinase (FAK) Over-Expression and Prognostic Implication in Pediatric Hepatocellular Carcinoma. [PDF]

Int J Mol Sci, 2020
Francalanci P, Giovannoni I, De Stefanis C, Romito I, Grimaldi C, Castellano A, D'Oria V, Alaggio R, Alisi A.   +8 more
europepmc   +1 more source

The Role of Endothelial Focal Adhesion Kinase (FAK) and FAK Related Non-Kinase (FRNK) in Leukocyte Recruitment

, 2017
Endothelial cells form the first barrier that leukocytes have to breach in order to reach the site of inflammation. Focal adhesions are the cellular structures that connect the endothelial cytoskeleton to the extracellular matrix. Focal adhesion kinase (FAK) is a signalling protein that is localized to focal adhesions and becomes phosphorylated during ...
openaire   +2 more sources

Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin, Xingya Wang, Yangtao Wu, Qian Liu, Qian Ren, Hui Wang, Jingbo Zhai   +6 more
wiley   +1 more source

Neutrophils: Heterogeneity, Biology, Diseases, and Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Neutrophils exhibit remarkable functional plasticity and play dual roles in tissue protection and disease progression. This review summarizes their key biological functions and highlights the shift from conventional broad‐spectrum interventions to neutrophil‐based drug delivery systems.
Yibing Zhang, Siwen Wu, Yusi Wang, Die Hu, Li Yang   +4 more
wiley   +1 more source

Therapeutic effects of tyroservatide on metastasis of lung cancer and its mechanism affecting integrin–focal adhesion kinase signal transduction

Drug Design, Development and Therapy, 2016
Yu-ting Huang,1,* Lan Zhao,1,* Zheng Fu,1 Meng Zhao,1 Xiao-meng Song,1 Jing Jia,1 Song Wang,1 Jin-ping Li,1 Zhi-feng Zhu,1 Gang Lin,1,2 Rong Lu,1,2 Zhi Yao1,3 1Department of Immunology, Tianjin Medical University, Tianjin, 2Shenzhen Kangzhe ...
Huang YT, Zhao L, Fu Z, Zhao M, Song XM, Jia J, Wang S, Li JP, Zhu ZF, Lin G, Lu R, Yao Z   +11 more
doaj  

New Treatment Strategy and Future Research Direction for BRAF‐Mutated Cancer

Cancer Science, Volume 117, Issue 11, Page 2901-2909, November 2026.
Treatment with BRAF inhibitor plus MEK inhibitor is currently used in BRAF‐mutated various malignancies except colorectal cancer, and treatments with BRAF and/or MEK inhibitors and anti‐EGFR antibody are used in BRAF‐mutated colorectal cancer. Despite recent advances in BRAF‐targeted therapies, their efficacy is still limited.
Masanobu Takahashi, Sakura Hiraide Taniguchi, Yuya Yoshida   +2 more
wiley   +1 more source

The novel role of T2R14 antagonism, by LW129, on VEGF‐induced lung endothelial neovascularisation processes in vitro

Physiological Reports, Volume 14, Issue 21, November 2026.
Abstract Pulmonary vascular remodelling, driven by dysregulated angiogenesis, is a hallmark of several cardiopulmonary diseases, yet the molecular pathways regulating endothelial responses remain incompletely understood. Bitter taste receptors (T2Rs), traditionally recognised as chemosensory receptors, have emerged as important modulators of vascular ...
Lewis Spurrier‐Best, Ellizabeth O. Harrington, Havovi Chichger   +2 more
wiley   +1 more source