Results 181 to 190 of about 1,278,750 (244)

Healthy Participant Versus Patient Selection for Clinical Pharmacology Studies in Small‐Molecule Oncology Drug Development

Clinical and Translational Science, Volume 19, Issue 11, November 2026.
Paridhi Gupta, Zheyi Hu, Li Zhu, Lora Hamuro   +3 more
wiley   +1 more source

Immunohistochemistry identifies E-cadherin, N-cadherin and focal adhesion kinase (FAK) as predictors of stage I non-small cell lung carcinoma spread through the air spaces (STAS), and the combinations as prognostic factors. [PDF]

Transl Lung Cancer Res
Meng Y, Wang Y, Liu L, Wu R, Zhang Q, Chen Z, Yao Y, Li X, Gong Y, Li H, Wang Z, Liu H.   +11 more
europepmc   +1 more source

Focal adhesion kinase (FAK) phosphorylation is a key regulator of embryonal rhabdomyosarcoma (ERMS) cell viability and migration. [PDF]

J Cancer Res Clin Oncol, 2019
Al-Ghabkari A, Qasrawi DO, Alshehri M, Narendran A.   +3 more
europepmc   +1 more source

AKT2^S128/CCTα^S315/319/323-positive cancer-associated fibroblasts (CAFs) mediate focal adhesion kinase (FAK) inhibitors resistance via secreting phosphatidylcholines (PCs). [PDF]

Signal Transduct Target Ther
Chen J, Zhang L, Zhu Y, Zhao D, Zhang J, Zhu Y, Pang J, Xiao Y, Wu Q, Wang Y, Zhan Q.   +10 more
europepmc   +1 more source

Randomized, Open-Label, Crossover Studies Evaluating the Effect of Food and Liquid Formulation on the Pharmacokinetics of the Novel Focal Adhesion Kinase (FAK) Inhibitor BI 853520. [PDF]

Target Oncol, 2019
Verheijen RB, van der Biessen DAJ, Hotte SJ, Siu LL, Spreafico A, de Jonge MJA, Pronk LC, De Vos FYFL, Schnell D, Hirte HW, Steeghs N, Lolkema MP.   +11 more
europepmc   +1 more source

Daurinol blocks breast and lung cancer metastasis and development by inhibition of focal adhesion kinase (FAK). [PDF]

Oncotarget, 2017
Woo JK, Jung HJ, Park JY, Kang JH, Lee BI, Shin D, Nho CW, Cho SY, Seong JK, Oh SH.   +9 more
europepmc   +1 more source

PINK1 promotes the progression of lung squamous cell carcinoma through the FAK/AKT/RhoA/vinculin pathway. [PDF]

Oncol Rep
Li X, Ma Y.
europepmc   +1 more source

A marine-derived sesterterpenoid inhibits migration and invasion of triple-negative breast cancer cells by suppressing the FAK signaling pathway. [PDF]

Front Cell Dev Biol
Wen H, Zeng F, Lan Y, Yin Y, Huang Y, Hu Y, Yin J, Li J, Zhou S, Hong K.   +9 more
europepmc   +1 more source

Prognostic Value of Focal Adhesion Kinase (FAK) in Human Solid Carcinomas: A Meta-Analysis. [PDF]

PLoS One, 2016
Zeng XQ, Li N, Ma LL, Tseng YJ, Zhao NQ, Chen SY.   +5 more
europepmc   +1 more source