Results 211 to 220 of about 1,278,750 (244)
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Focal Adhesion: Eph Kinases Suppress the FAKs.
Science Signaling, 2000Eph kinases and their cognate ligands, ephrins, are located at the surface of cells in reciprocal compartments of embryos where they define organ boundaries by restricting cell migration. Though it remains unknown how Eph kinases and ephrins delineate these boundaries, it is likely that intracellular cell adhesion proteins are substrates ...
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Focal Adhesion Kinase (FAK) Tyrosine 397E Mutation Restores the Vascular Leakage Defect in Endothelium-Specific FAK-Kinase Dead Mice [PDF]
Journal of Pathology, 2017 Focal adhesion kinase (FAK) inhibitors have been developed as potential anti-cancer agents and are in clinical trials. In vitro activation of FAK kinase domain triggers autophosphorylation of tyrosine 397 (Y397), Src activation and subsequent ...
Natalia Bodrug +2 more
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Role of focal adhesion kinase (FAK) in renal ischaemia and reperfusion
Pflügers Archiv - European Journal of Physiology, 2007Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, plays important roles in cell migration, cell proliferation and cell survival. Because these processes participate in the restoration of tubular integrity in renal ischaemia and reperfusion, FAK expression and phosphorylation at Tyr-397, the latter indicative of its activity, were examined in
Konstantin, Holzapfel +4 more
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Focal Adhesion Kinase (FAK) Expression and Phosphorylation in Sea Urchin Embryos
Gene Expression Patterns, 2004We have cloned three cDNA isoforms of focal adhesion kinase (FAK) from the sea urchin, Lytechinus variegatus. The sea urchin FAK is more closely related to FAK from other deuterostomes than from invertebrate protostomes or to cell adhesion kinase beta (CAKbeta/Pyk2/FAK2).
María Guadalupe, García +2 more
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Focal adhesion kinase (FAK): its structure, characteristics, and signaling in skeletal system
Cellular Signalling, 2023Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and distributes important regulatory functions in skeletal system. Mesenchymal stem cell (MSC) possesses significant migration and differentiation capacity, is an important source of distinctive bone cells production and a prominent bone development pathway.
Yuping, Huang +3 more
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Progress in the Development of Small Molecular Inhibitors of Focal Adhesion Kinase (FAK)
Journal of Medicinal Chemistry, 2020Focal adhesion kinase (FAK) is a nonreceptor intracellular tyrosine kinase that plays an essential role in cancer cell adhesion, survival, proliferation, and migration through both its enzymatic activities and scaffolding functions. Overexpression of FAK has been found in many human cancer cells from different origins, which promotes tumor progression ...
Yang Lu, Haiying Sun
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Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor
Biochemical and Biophysical Research Communications, 2009Recent studies have shown a direct association between IGF-1R and FAK, two important mediators of cell growth, survival and migration. However, the mechanism by which FAK affects IGF-1R function remains unknown. This study investigates the potential role of FAK in mediating activation and stability of IGF-1R.
Sandra, Andersson +3 more
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Focal Adhesion Kinase (FAK) and c-Src Dependent Signal Transduction in Cell Adhesion
Discovery MedicineThis review predominantly acquaints the role of focal adhesion kinase (FAK) and cellular-Src (c-Src) in cell adhesion. Cell adhesion is a crucial phenomenon that causes the cells to interact with the extracellular matrix (ECM) or with each other. There are different proteins involved in cell adhesion including cell adhesion molecules (CAMs)/receptors ...
Kazuo Katoh
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Focal adhesion kinase (FAK) perspectives in mechanobiology: implications for cell behaviour
Cell and Tissue Research, 2014Mechanobiology is a scientific interface discipline emerging from engineering and biology. With regard to tissue-regenerative cell-based strategies, mechanobiological concepts, including biomechanics as a target for cell and human mesenchymal stem cell behaviour, are on the march.
Tomakidi, Pascal +4 more
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[Focal adhesion kinase (FAK), a multifunctional protein].
Medecine sciences : M/S, 2003Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase localized to regions called focal adhesions. Many stimuli can induce tyrosine phosphorylation and activation of FAK, including integrins and growth factors. The major site of autophosphorylation, tyrosine 397, is a docking site for the SH2 domains of Src family proteins.
Jérôme, Cornillon +2 more
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