Results 1 to 10 of about 51,195 (186)

FAK acts as a suppressor of RTK-MAP kinase signalling in Drosophila melanogaster epithelia and human cancer cells. [PDF]

PLoS Genetics, 2014
Receptor Tyrosine Kinases (RTKs) and Focal Adhesion Kinase (FAK) regulate multiple signalling pathways, including mitogen-activated protein (MAP) kinase pathway. FAK interacts with several RTKs but little is known about how FAK regulates their downstream
Juan Pablo Macagno, Jesica Diaz Vera, Yachuan Yu, Iain MacPherson, Emma Sandilands, Ruth Palmer, Jim C Norman, Margaret Frame, Marcos Vidal   +8 more
doaj   +6 more sources

Phosphorylation of p130Cas initiates Rac activation and membrane ruffling [PDF]

BMC Cell Biology, 2008
Background Non-receptor tyrosine kinases (NTKs) regulate physiological processes such as cell migration, differentiation, proliferation, and survival by interacting with and phosphorylating a large number of substrates simultaneously.
Sharma Alok, Mayer Bruce J
doaj   +3 more sources

Inhibition of focal adhesion kinase enhances antitumor response of radiation therapy in pancreatic cancer through CD8+ T cells

Cancer Biology & Medicine, 2021
Objective: Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy, due in large part to its resistance to conventional therapies, including radiotherapy (RT).
Arsen Osipov, Alex B. Blair, Juliane Liberto, Jianxin Wang, Keyu Li, Brian Herbst, Yao Xu, Shiqi Li, Nan Niu, Rufiaat Rashid, Ding Ding, Yanan Liu, Zaiqi Wang, Christopher L. Wolfgang, Richard A. Burkhart, Daniel Laheru, Lei Zheng   +16 more
doaj   +1 more source

A role for the protein tyrosine phosphatase CD45 in macrophage adhesion through the regulation of paxillin degradation. [PDF]

PLoS ONE, 2013
CD45 is a protein tyrosine phosphatase expressed on all cells of hematopoietic origin that is known to regulate Src family kinases. In macrophages, the absence of CD45 has been linked to defects in adhesion, however the molecular mechanisms involved ...
Joëlle St-Pierre, Hanne L Ostergaard
doaj   +1 more source

Regulation of Fibroblast Cell Polarity by Src Tyrosine Kinase

Biomedicines, 2021
Src protein tyrosine kinases (SFKs) are a family of nonreceptor tyrosine kinases that are localized beneath the plasma membrane and are activated during cell adhesion, migration, and elongation.
Kazuo Katoh
doaj   +1 more source

PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility

Cells, 2020
Paraspeckle protein 1 (PSPC1) overexpression in cancers is known to be the pro-metastatic switch of tumor progression associated with poor prognosis of cancer patients.
Hsin-Wei Jen, De-Leung Gu, Yaw-Dong Lang, Yuh-Shan Jou   +3 more
doaj   +1 more source

SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes. [PDF]

PLoS ONE, 2014
Reactive oxygen species (ROS) regulate diverse cellular functions by triggering signal transduction events, such as Src and mitogen-activated protein (MAP) kinases.
Ara Jo, Hyunju Park, Sung-Hee Lee, So-Hee Ahn, Hee Ja Kim, Eun-Mi Park, Youn-Hee Choi   +6 more
doaj   +1 more source

CB1 Cannabinoid Receptors Stimulate Gβγ-GRK2-Mediated FAK Phosphorylation at Tyrosine 925 to Regulate ERK Activation Involving Neuronal Focal Adhesions

Frontiers in Cellular Neuroscience, 2020
CB1 cannabinoid receptors (CB1) are abundantly expressed in the nervous system where they regulate focal adhesion kinase (FAK) and the mitogen-activated protein kinases (MAPK) extracellular signal-regulated kinase 1 and 2 (ERK1/2).
George D. Dalton, Skyla T. Carney, Jamie D. Marshburn, Derek C. Norford, Allyn C. Howlett   +4 more
doaj   +1 more source

DUSP3 regulates phosphorylation-mediated degradation of occludin and is required for maintaining epithelial tight junction

Journal of Biomedical Science, 2022
Background Tight junctions (TJ) are multi-protein complexes that hold epithelial cells together and form structural and functional barriers for maintaining proper biological activities.
Hsiao-Chin Chou, Chun-Mei Cheng, Chi-Hwa Yang, Tzu-Yin Lin, Ya-Wen Liu, Tse-Hua Tan, Yi-Rong Chen   +6 more
doaj   +1 more source

ADAM15 modulates outside-in signalling in chondrocyte–matrix interactions [PDF]

, 2008
ADAM15 belongs to a family of transmembrane multi-domain proteins implicated in proteolysis, cell–cell and cell–matrix interactions in various disease conditions.
Burkhardt, Harald, Böhm, Beate B., Schirner, Andrea   +2 more
core   +1 more source