Results 11 to 20 of about 51,195 (186)

Protein tyrosine phosphatase 1B targets focal adhesion kinase and paxillin in cell–matrix adhesions

Journal of Cell Science, 2021
ABSTRACT Protein tyrosine phosphatase 1B (PTP1B, also known as PTPN1) is an established regulator of cell-matrix adhesion and motility. However, the nature of substrate targets at adhesion sites remains to be validated. Here, we used bimolecular fluorescence complementation assays, in combination with a substrate trapping mutant of PTP1B,
Ana E. González Wusener, Ángela González, María E. Perez Collado, Melina R. Maza, Ignacio J. General, Carlos O. Arregui   +5 more
openaire   +2 more sources

Protein-tyrosine Phosphatase PTPD1 Regulates Focal Adhesion Kinase Autophosphorylation and Cell Migration [PDF]

Journal of Biological Chemistry, 2008
PTPD1 is a cytosolic nonreceptor tyrosine phosphatase and a positive regulator of the Src-epidermal growth factor transduction pathway. We show that PTPD1 localizes along actin filaments and at adhesion plaques. PTPD1 forms a stable complex via distinct molecular modules with actin, Src tyrosine kinase, and focal adhesion kinase (FAK), a scaffold ...
Carlucci A, Gedressi C, Lignitto L, Nezi L, Villa Moruzzi E, AVVEDIMENTO, VITTORIO ENRICO, Gottesman M, GARBI, CORRADO, FELICIELLO, ANTONIO   +8 more
openaire   +4 more sources

Cloning and Characterization of Cell Adhesion Kinase β, a Novel Protein-tyrosine Kinase of the Focal Adhesion Kinase Subfamily [PDF]

Journal of Biological Chemistry, 1995
A second protein-tyrosine kinase (PTK) of the focal adhesion kinase (FAK) subfamily, cell adhesion kinase beta (CAK beta), was identified by cDNA cloning. The rat CAK beta is a 115.7-kDa PTK that contains N- and C-terminal domains of 418 and 330 amino acid residues besides the central kinase domain.
H, Sasaki, K, Nagura, M, Ishino, H, Tobioka, K, Kotani, T, Sasaki   +5 more
openaire   +2 more sources

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions. [PDF]

Proceedings of the National Academy of Sciences, 1992
Expression of the Rous sarcoma virus-encoded oncoprotein, pp60v-src, subverts the normal regulation of cell growth, which results in oncogenic transformation. This process requires the intrinsic protein-tyrosine kinase activity of pp60v-src and is associated with an increase in tyrosine phosphorylation of a number of cellular proteins, candidate ...
M D, Schaller, C A, Borgman, B S, Cobb, R R, Vines, A B, Reynolds, J T, Parsons   +5 more
openaire   +2 more sources

Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT [PDF]

Oncogene, 2012
Protein tyrosine kinase 6 (PTK6) is a non-receptor tyrosine kinase expressed in epithelial cancers. Disruption of Ptk6 decreases azoxymethane-induced colon tumorigenesis in mice by preventing signal transducer and activator of transcription 3 activation. Relocalization of PTK6 in prostate cancers contributes to increased growth.
Zheng, Yu, Gierut, Jessica, Wang, Zebin, Miao, Jianjun, Tyner, Angela L., Asara, John   +5 more
openaire   +3 more sources

Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin. [PDF]

Proceedings of the National Academy of Sciences, 1992
A homology-based cDNA cloning approach was used to identify a widely expressed protein-tyrosine kinase designated as "focal adhesion kinase" (FadK). The entire mouse FadK amino acid sequence was deduced from cDNA clones, revealing a large (119-kDa) non-membrane-spanning protein-tyrosine kinase that lacks Src-homology SH2 and SH3 domains. Immunostaining
S K, Hanks, M B, Calalb, M C, Harper, S K, Patel   +3 more
openaire   +2 more sources

Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK. [PDF]

Molecular and Cellular Biology, 1993
Integrins play a central role in cellular adhesion and anchorage of the cytoskeleton and participate in the generation of intracellular signals, including tyrosine phosphorylation. We have recently isolated a cDNA encoding a unique, focal adhesion-associated protein tyrosine kinase (FAK) that is a component of an integrin-mediated signal transduction ...
M D, Schaller, C A, Borgman, J T, Parsons   +2 more
openaire   +2 more sources

Angiotensin II Type I Receptor (AT1R): The Gate towards COVID-19-Associated Diseases

Molecules, 2022
The binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein to its cellular receptor, the angiotensin-converting enzyme 2 (ACE2), causes its downregulation, which subsequently leads to the dysregulation of the renin–
George El-Arif, Shaymaa Khazaal, Antonella Farhat, Julien Harb, Cédric Annweiler, Yingliang Wu, Zhijian Cao, Hervé Kovacic, Ziad Abi Khattar, Ziad Fajloun, Jean-Marc Sabatier   +10 more
doaj   +1 more source

FUS-CHOP promotes invasion in myxoid liposarcoma through a SRC/FAK/RHO/ROCK-dependent pathway [PDF]

, 2017
Deregulated SRC/FAK signaling leads to enhanced migration and invasion in many types of tumors. In myxoid and round cell liposarcoma (MRCLS), an adipocytic tumor characterized by the expression of the fusion oncogene FUS-CHOP, SRC have been found as one ...
González, M. Victoria, Hermida Prado, Francisco, Singh Singh, Ranjit, Tornin Cavielles, Juan   +3 more
core   +2 more sources

Interactions of the Protein-tyrosine Phosphatase-α with the Focal Adhesion Targeting Domain of Focal Adhesion Kinase Are Involved in Interleukin-1 Signaling in Fibroblasts [PDF]

Journal of Biological Chemistry, 2014
Interleukin-1 (IL-1) signaling in fibroblasts is mediated through focal adhesions, organelles that are enriched with adaptor and cytoskeletal proteins that regulate signal transduction. We examined interactions of the focal adhesion kinase (FAK) with protein-tyrosine phosphatase-α (PTP-α) in IL-1 signaling.
Qin, Wang, Yongqiang, Wang, Dominik, Fritz, Dhaarmini, Rajshankar, Gregory P, Downey, Christopher A, McCulloch   +5 more
openaire   +2 more sources