Results 211 to 220 of about 25,087 (234)

Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

Nature, 1992
Increasing evidence indicates that the integrin family of cell adhesion receptors can transduce biochemical signals from the extracellular matrix to the cell interior to modulate cell growth and differentiation. We have shown that integrin/ligand interactions can trigger tyrosine phosphorylation of a protein of M(r) 120,000 (pp120), so it is possible ...
Jun-Lin Guan, David Shalloway, Guan Jun-Lin   +2 more
exaly   +3 more sources

Focal adhesion kinase: an integrin-linked protein tyrosine kinase

Trends in Cell Biology, 1993
Recent evidence has shown that binding of integrins to components of the extracellular matrix serves to initiate cellular signals, resulting in changes in cytoskeletal architecture and activation of intracellular signalling pathways. Here we review the evidence that protein tyrosine kinases, including focal-adhesion-associated kinases, play a central ...
Michael D Schaller, J T Parsons
exaly   +3 more sources

Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma

Cancer, 1999
Focal adhesion kinase (FAK) is a tyrosine kinase that is important to such key functions such as cell adhesion, motility, and invasion. A MEDLINE search of the years 1980-1998 found no previous reports of FAK expression in human ovarian carcinoma. The authors performed experiments to determine whether FAK expression is elevated in this disease.Ten ...
Xiaping He, William G Cance, W G Cance
exaly   +3 more sources

Rat oligodendroglia express c-met and focal adhesion kinase, protein tyrosine kinases implicated in regulating epithelial cell motility

Neuroscience Letters, 2000
Oligodendrocytes, the myelinating cells of the central nervous system, arise from a profilerating pool of motile progenitor cells. The proliferation and survival of these cells is dependent on signal transduction via several protein tyrosine kinases (PTKs) including receptors for fibroblast growth factor -2, the platelet-derived growth factor receptors
Trevor J Kilpatrick, Cary Lai, Greg Lemke   +2 more
exaly   +3 more sources

Focal Adhesion Kinase–Related Protein Tyrosine Kinase Pyk2 in T-Cell Activation and Function

Immunologic Research, 2005
Pyk2 is a protein tyrosine kinase expressed primarily in brain and hematopoietic cells. It becomes activated in response to stimulation through numerous receptors, including integrins, chemokine receptors, and antigen receptors, and is found in association with src-family kinases. Although this enzyme associates with many proteins known to be important
Hanne L, Ostergaard, Tara L, Lysechko
openaire   +2 more sources

Targeting Vascular Cell Migration as a Strategy for Blocking Angiogenesis: The Central Role of Focal Adhesion Protein Tyrosine Kinase Family

Current Pharmaceutical Design, 2007
The formation of capillary-like structures during angiogenesis requires a series of well-orchestrated cellular events allowing endothelial cells and pericytes to migrate into the perivascular space. The proper activation of the migratory machinery in these cells is fine controlled by the presence of angiogenic challenges and by the interactions with ...
ANGELUCCI, ADRIANO, BOLOGNA, Mauro
openaire   +3 more sources

The focal adhesion kinase Pyk2 links Ca2+ signalling to Src family kinase activation and protein tyrosine phosphorylation in thrombin-stimulated platelets

Biochemical Journal, 2015
In blood platelets, stimulation of G protein-coupled receptors (GPCRs) by thrombin triggers the activation of Src family kinases (SFKs), resulting in the tyrosine-phosphorylation of multiple substrates, but the mechanism underlying this process is still poorly understood.
Canobbio, I., Cipolla, L., Guidetti, G., Manganaro, D., Visconte, C., Kim, S., Okigaki, M., Falasca, Marco, Kunapuli, S., Torti, M.   +9 more
openaire   +3 more sources

Melanoma cell spreading on fibronectin induced by 12(S)‐HETE involves both protein kinase C‐ and protein tyrosine kinase‐dependent focal adhesion formation and tyrosine phosphorylation of focal adhesion kinase (pp125^FAK)

Journal of Cellular Physiology, 1995
AbstractOur previous work demonstrated that 12(S)‐HETE, a lipoxygenase metabolite of arachidonic acid, promoted B16 amelanotic melanoma (B16a) cell spreading on fibronectin. In the current study, we investigated the biochemical mechanisms of the 12(S)‐HETE induced response.
D G, Tang, M, Tarrien, P, Dobrzynski, K V, Honn   +3 more
openaire   +2 more sources

[Expression analysis of protein tyrosine kinases of the FAK (focal adhesion kinase) family in osteosarcoma].

Der Pathologe, 2002
Expression analysis of the protein tyrosine kinases, focal adhesion kinase (FAK) and proline-rich tyrosine kinase2 (Pyk2) in high grade osteosarcomas.Expression of the kinases was evaluated qualitatively by immunohistochemical staining and quantitatively by real-time PCR.Osteoblastic cells of high grade osteosarcomas show a distinct FAK expression but ...
A, Schröder, G, Delling, E A, Kaiser
openaire   +1 more source

Abstract A249: BI 853520, a potent and highly selective inhibitor of protein tyrosine kinase 2 (focal adhesion kinase), shows efficacy in multiple xenograft models of human cancer.

Molecular Cancer Therapeutics, 2011
Abstract PTK2/FAK is a widely expressed non-receptor tyrosine kinase located mainly at focal adhesions. Sensing upstream signals from growth factor receptors as well as integrins, the enzyme contributes to activation of multiple downstream signaling pathways involved in the regulation of cell survival, proliferation and motility.
Ulrich A. Hirt, Juergen Braunger, Michael Schleicher, Ulrike Weyer-Czernilofsky, Pilar Garin-Chesa, Bojan Bister, Heinz Stadtmueller, Ioannis Sapountzis, Norbert Kraut, Guenther R. Adolf   +9 more
openaire   +1 more source