NPHS2 mutation analysis shows genetic heterogeneityof steroid-resistant nephrotic syndrome and lowpost-transplant recurrence [PDF]
NPHS2 mutation analysis shows genetic heterogeneity of steroid-resistant nephrotic syndrome and low post-transplant recurrence.BackgroundMutations of NPHS2 are causative in familial autosomal-recessive (AR) and sporadic steroid-resistant nephrotic ...
Weber, Stefanie +7 more
core +1 more source
Full-length soluble urokinase plasminogen activator receptor down-modulates nephrin expression in podocytes [PDF]
Increased plasma level of soluble urokinase-type plasminogen activator receptor (suPAR) was associated recently with focal segmental glomerulosclerosis (FSGS).
Alfano, Massimo +14 more
core +2 more sources
Idiopathic focal segmental glomerulosclerosis and HLA antigens
The objective of the present study was to investigate a possible association between HLA class II antigens and idiopathic focal segmental glomerulosclerosis (FSGS).
M. Gerbase-DeLima +5 more
doaj +1 more source
Active focal segmental glomerulosclerosis is associated with massive oxidation of plasma albumin [PDF]
The basic mechanism for idiopathic FSGS still is obscure. Indirect evidence in humans and generation of FSGS by oxidants in experimental models suggest a role of free radicals.
BRUSCHI M +12 more
core +1 more source
Activation of podocyte Notch mediates early Wt1 glomerulopathy [PDF]
The Wilms' tumor suppressor gene, WT1, encodes a zinc finger protein that regulates podocyte development and is highly expressed in mature podocytes. Mutations in the WT1 gene are associated with the development of renal failure due to the formation of ...
Alex K. Virasami +58 more
core +1 more source
Focal Segmental Glomerulosclerosis: Histopathology Discussion
Brian Mark Churchill +3 more
doaj +1 more source
Focal Segmental Glomerulosclerosis: A Single Center Experience
Aim: Focal segmental glomerulosclerosis (FSGS) is one of the most common glomerulonephritis (GNP) worldwide. Despite treatment, it may progress to end-stage renal disease. In the present study, we compared clinical and histopathological data on FSGS with
Yavuz Ayar +14 more
doaj +1 more source
Effects of intrauterine food restriction and long-term dietary supplementation with L-arginine on age-related changes in renal function and structure of rats [PDF]
We have previously demonstrated that restricting intrauterine food by 50% in 3-mo-old rats produced lower nephron numbers and early-onset hypertension, the latter being normalized by L-arginine administration.
Alpers CE +49 more
core +1 more source
Experimental rat models of chronic allograft nephropathy: a review [PDF]
Chronic allograft nephropathy (CAN) is the leading cause of late allograft loss after renal transplantation (RT), which continues to remain an unresolved problem. A rat model of CAN was first described in 1969 by White et al. Although the rat model of RT
Haylor, John, Shrestha, Badri
core +2 more sources
Brain and Lung Abscesses in a 48-year-old Man with Focal and Segmental Glomerulosclerosis. [PDF]
Focal segmental sclerosis (FSGS) is a common cause of idiopathic nephrotic syndrome in the adult population. A patient aged 48- year-old was admitted for evaluation of azotemia. Renal biopsy showed tip lesion FSGS and acute tubular necrosis. After methyl
Momeni, A., Nasri, H., Rahmani, F.
core +1 more source

