Results 81 to 90 of about 27,806 (222)

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, Volume 13, Issue 10, 18 February 2026.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

Fanconi Syndrome After a Single Exposure to Intravenous Zoledronic Acid

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Bisphosphonates are commonly used to reduce fracture risk in patients with osteoporosis, in those with malignant metastatic bone disease and for treatment of malignant hypercalcaemia. We present the case of a woman in her 80s admitted with recurrent falls who developed Fanconi syndrome after a single dose of intravenous Zoledronic acid despite
Rita Deb, Muhammad Elboghdady, Alvin Shrestha   +2 more
wiley   +1 more source

C4d expression in focal segmental glomerulosclerosis

Nefrología (English Edition)
Background: There is a little information about of expression of C4d (complement fragment) in Focal segmental glomerulosclerosis (FSGS) subtypes. Our aim was to determine the expression of C4d in FSGS subtypes in percutaneous native renal biopsies in a ...
Venice Chávez Valencia, Victoriano Pérez-Vázquez, Anel Gómez García, Katya Vargas-Ortiz, Martha Arisbeth Villanueva Pérez, Marisol Godínez Rubí, Leonardo Pazarín Villaseñor, Sergio Gutiérrez Castellanos, Citlalli Orizaga de la Cruz   +8 more
doaj   +1 more source

A Case of Nephrotic Syndrome, Showing Evidence of Response to Saquinavir

Case Reports in Nephrology, 2015
The treatment of primary nephrotic syndrome such as minimal change nephropathy, membranous nephropathy, and focal segmental glomerulosclerosis nephropathy remains challenging.
Giles Walters, Faisal A. Choudhury, Budhima Nanayakkara   +2 more
doaj   +1 more source

Peritoneal Dialysis‐Related Mycobacterium fortuitum Exit‐Site/Tunnel Infection in a Pediatric Patient: A Case Report

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT In patients in peritoneal dialysis (PD) who develop exit site and/or catheter tunnel infections, expeditious identification of the causative organism and early implementation of treatment are important to ensure good outcomes. Among the many causative organisms, the diagnosis of Mycobacterium fortuitum is particularly challenging, with its ...
Rina Takahashi, Hiroshi Tamura, Keishiro Furuie, Hiroko Nagata, Shohei Kuraoka   +4 more
wiley   +1 more source

Primary focal segmental glomerulosclerosis in second trimester pregnancy presenting as rapidly progressive renal failure: diagnostic and therapeutic challenges: a case report

Journal of Medical Case Reports
Background Proteinuria in pregnancy is often attributed to preeclampsia, but primary glomerular diseases such as focal segmental glomerulosclerosis can also present during pregnancy, complicating diagnosis and management.
Adane Petros, Addisu Melkie, Yidnekachew Asrat, Fitsum A. Gemechu, Yewondwossen Tadesse   +4 more
doaj   +1 more source

Genetic testing for nephrotic syndrome and FSGS in the era of next-generation sequencing [PDF]

, 2014
The haploid human genome is composed of three billion base pairs, about one percent of which consists of exonic regions, the coding sequence for functional proteins, also now known as the “exome”.
Barua, Moumita, Brown, Elizabeth J., Pollak, Martin R.   +2 more
core   +1 more source

Expanded Phenotype of PAX2‐Related Papillorenal Syndrome: A Case Featuring FSGS, Atypical Retinopathy, Cerebellar Hypoplasia, and ADHD

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Papillorenal syndrome (PAPRS), or renal coloboma syndrome, is a rare autosomal dominant disorder caused by PAX2 mutations. It classically manifests with renal hypodysplasia and optic nerve anomalies. However, recent literature suggests an expanding phenotypic spectrum.
Nadira Sultana, Abdullah Al Mamun, Afroza Begum   +2 more
wiley   +1 more source

Clinical and pathological characteristics of patients with glomerular diseases at a university teaching hospital: 5-year prospective review [PDF]

, 1999
OBJECTIVE. To examine the prevalence of glomerular disease in Hong Kong. DESIGN. Prospective review. SETTING. University teaching hospital, Hong Kong. PATIENTS. All patients who presented with suspected glomerular disease from 1993 through 1997. MAIN
Chan, DTM, Chan, KW, Cheng, IKP
core  

Therapeutic Potential of Mesenchymal Stem Cells in Pediatric Kidney Disorders: A Comprehensive Review

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background Kidney diseases in children present significant health challenges, often leading to complications and reduced quality of life. Mesenchymal stem cell (MSC) therapy shows promise for pediatric kidney disorders. This review evaluates current evidence on MSC applications in pediatric nephrology, focusing on mechanisms, delivery methods,
Mahboube Bahroudi, Mastaneh Moghtaderi
wiley   +1 more source