Results 41 to 50 of about 1,404,808 (156)

Folate-Guided Protein Degradation by Immunomodulatory Imide Drug-Based Molecular Glues and Proteolysis Targeting Chimeras

, 2021
Molecular glues and proteolysis targeting chimeras (PROTACs) are promising new therapeutic modalities. However, the lack of specificity for molecular glue- or PROTAC-mediated proteolysis in cancer cells versus normal cells raises potential toxicity ...
Wenyi Wei (6911471), Jian Jin, He Chen (104732), H. Ümit Kaniskan, Jing Liu, He Chen, Wenyi Wei, Jing Liu (38537), H. Ümit Kaniskan (1476325), Jian Jin (351142)   +9 more
core   +2 more sources

folate

, 2015
comparison of folate vs.
Azita Hekmatdoost (825771)
core   +1 more source

Imaging of folate receptor expressing macrophages in the rat groove model of osteoarthritis: Using a new DOTA-folate conjugate [PDF]

, 2017
Objective. To evaluate the presence and localization of folate receptor expressing macrophages in the rat groove model of osteoarthritis and determine the suitability of a new folate conjugate with albumin-binding entity (cm09) for in vivo SPECT (single ...
Lafeber, F.P.J.G. (author), Weinans, Harrie (author), de Visser, Huub M., Müller, C. (author), Mastbergen, S.C. (author), Lafeber, Floris P J G, Krijger, G.C. (author), Simon C. Mastbergen, LS Equine Muscoskeletal Biology, Freek J. Beekman, dES RMSC, Mastbergen, Simon C., Harrie Weinans, Beekman, F.J. (author), Korthagen, Nicoline M, Nicoline M. Korthagen, Krijger, Gerard C, Weinans, Harrie, Korthagen, Nicoline M., Gerard C. Krijger, de Visser, H.M. (author), Krijger, Gerard C., Lafeber, Floris P.J.G., de Visser, Huub M, Beekman, Freek J, Huub M. de Visser, Müller, Cristina, Cristina Müller, Beekman, Freek J., Ramakers, R.M. (author), Korthagen, NM (author), Floris P. J. G. Lafeber, Mastbergen, Simon C, Ramakers, Ruud M, Ramakers, Ruud M., Ruud M. Ramakers, Brain, Krijger, Gerard C. (author), Mastbergen, Simon C. (author), Lafeber FPJG, Translational Neuroscience, Korthagen, Nicoline M. (author), Weinans H, Radionuclide Apotheek, Krijger GC, Korthagen NM, Mastbergen SC, Müller, Cristina (author), Ramakers, Ruud M. (author), Regenerative Medicine and Stem Cells, Ramakers RM, Lab Reumatologie/Klinische Immunologie, Müller C, Other research (not in main researchprogram), Beekman FJ, de Visser, Huub M. (author), Beekman, Freek J. (author), Lafeber, Floris P.J.G. (author), Infection & Immunity, de Visser HM, Verpleegafd Orthopaedie D4 west, Cancer   +61 more
core   +1 more source

The therapeutic effect of methotrexate-conjugated Pluronic-based polymeric micelles on the folate receptor-rich tumors treatment

International Journal of Nanomedicine, 2015
Yanzuo Chen,1–3 Wei Zhang,2,4 YuKun Huang,1 Feng Gao,1 Xianyi Sha,2 Kaiyan Lou,1 Xiaoling Fang21Department of Pharmaceutics, School of Pharmacy, East China University of Science and Technology, 2Key Laboratory of Smart Drug Delivery, Ministry of ...
Chen YZ, Zhang W, Huang YK, Gao F, Sha XY, Lou KY, Fang XL   +6 more
doaj  

Predict the Progression of Cervical Intraepithelial Neoplasia by a Novel Marker Folate Combine with FRα, p16 and Ki-67

International Journal of General Medicine, 2022
Tingting Liu, Mengjie Chen, Xueqin Li, He Wang Department of Gynecology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, People’s Republic of ChinaCorrespondence: He Wang, Department of Gynecology, Guangxi Medical University Cancer Hospital,
Liu T, Chen M, Li X, Wang H
doaj  

Targeted tumor theranostics using folate-conjugated and camptothecin-loaded acoustic nanodroplets in a mouse xenograft model

, 2017
In this study, we aimed to validate the feasibility of receptor-targeted tumor theranostics with folate-conjugated (FA) and camptothecin-loaded (CPT) acoustic nanodroplets (NDs) (collectively termed FA-CPT-NDs).
Chen, Wei-Tsung;Kang, Shih-Tsung;Lin, Jian-Liang;Wang, Chung-Hsin;Chen, Ran-Chou;Yeh, Chih-Kuang
core   +1 more source

Targeting diamond nanoparticles into folate-receptor expressing HeLa cells

, 2022
S.414-418We have studied binding of synthesized folic acid-diamond nanoparticle conjugates to proliferatively active HeLa cells. In order to determine the binding of the complex to the cells, we used spectral luminescence methods and microscopy, which ...
Vorobey, A.V., Pavich, T.A., Opitz, J., Lapina, V.A.   +3 more
core   +1 more source

Folate Receptor Targeting Probes for Two-Photon Fluorescence Bioimaging

, 2010
Two approaches to design folic acid conjugates for specific intracellular uptake against folate receptor-over expressing cancer cells are reported along with two-photon fluorescence microscopy imaging of HeLa cells demonstrated their uptake and folate ...
Kevin D. Belfield, Xuhua Wang, Belfield, Kevin D., Wang, Xuhua, Alma R. Morales, Morales, Alma R.   +5 more
core   +1 more source

PET Molecular Probes Targeting Folate Receptor

Journal of Isotopes, 2016
Folic acid can combine specifically with folate receptors (FRs) which are overexpressed on the epithelial cells of the tumor. The FRs are confirmed to be the tumor-associated antigens that bind folate and folate conjugates with very high affinity and ...
YIN Ji-lin1;WANG Cheng2;WANG Xin-lu1
doaj   +1 more source

Formulation Strategies for Folate-Targeted Liposomes and Their Biomedical Applications

Pharmaceutics, 2019
The folate receptor (FR) is a tumor-associated antigen that can bind with folic acid (FA) and its conjugates with high affinity and ingests the bound molecules inside the cell via the endocytic mechanism. A wide variety of payloads can be delivered to FR-
Parveen Kumar, Peipei Huo, Bo Liu
doaj   +1 more source