Folate Transporters in Placentas from Preterm Newborns and Their Relation to Cord Blood Folate and Vitamin B12 Levels. [PDF]
PLoS ONE, 2017 Folate deficiency during pregnancy has been related to low birth weight, preterm (PT) birth and other health risks in the offspring; however, it is unknown whether prematurity is related to low folate transport through the placenta due to altered ...
Erika Castaño +5 more
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Pteridines, 2015 Folate receptors and transporters as well as folate enzymes play an essential role in human disease and form important targets for the treatment of immune diseases and cancer.
Godefridus Johannes Peters
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Interaction between dolutegravir and folate transporters and receptor in human and rodent placenta [PDF]
EBioMedicine, 2022 Summary: Background: Due to the critical role of folates in neurodevelopment, it is important to understand potential interactions between anti-HIV drugs used during pregnancy, and folate delivery pathways in the placenta.
Julian C. Gilmore +6 more
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The upregulated intestinal folate transporters direct the uptake of ligand-modified nanoparticles for enhanced oral insulin delivery [PDF]
Acta Pharmaceutica Sinica B, 2022 Transporters are traditionally considered to transport small molecules rather than large-sized nanoparticles due to their small pores. In this study, we demonstrate that the upregulated intestinal transporter (PCFT), which reaches a maximum of 12.3-fold ...
Jingyi Li +11 more
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Journal of Experimental & Clinical Cancer Research, 2019 Folate receptors and transporters and one-carbon metabolism continue to be important areas of study given their essential roles in an assortment of diseases and as targets for treatment of cancer and inflammation.
Barbara Frigerio +7 more
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Biology of the Major Facilitative Folate Transporters SLC19A1 and SLC46A1 [PDF]
Current Topics in Membranes, 2014 This chapter focuses on the biology of the major facilitative membrane folate transporters, the reduced folate carrier (RFC), and the proton-coupled folate transporter (PCFT). Folates are essential vitamins, and folate deficiency contributes to a variety
Zhanjun Hou, Larry H Matherly
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Characterization of folic acid, 5-methyltetrahydrofolate and synthetic folinic acid in the high-affinity folate transporters: impact on pregnancy and development. [PDF]
Reprod Dev Med, 2023 Objectives: Folates are B vitamins that are essential for several molecular, cellular, and biological processes, including nucleotide synthesis, methylation, and methionine cycling.
Palacios AM, Feiner RA, Cabrera RM.
europepmc +2 more sources
Folate Transporters Are Found Throughout the Colon of Humans and Their mRNA Expression Appears to Be Unaffected by Low Dose Folic Acid Supplementation [PDF]
Curr Dev Nutr, 2021 A large depot of folate resides in the colon and can exceed dietary intake. Little is known about the capacity of the colon to absorb folate. We aimed to determine the expression of key folate transporters, reduced folate carrier (RFC) and proton ...
Colleen M Farrell +10 more
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Down-regulation of placental folate transporters in intrauterine growth restriction. [PDF]
J Nutr Biochem, 2018 Folate deficiency in pregnancy is associated with neural tube defects, restricted fetal growth and fetal programming of diseases later in life. Fetal folate availability is dependent on maternal folate levels and placental folate transport capacity ...
Chen YY +4 more
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Folate transporters at the plasma membrane of fungi and plants: specificity, mechanism of transport, and importance [PDF]
Biochem Soc TransFolates are essential metabolites of the cell and need to be acquired either by transport or biosynthesis. All metazoa including humans, some bacteria, and some protozoa acquire it solely through specific transporters. Plants and fungi, in contrast, have
Vashist N, Bachhawat A.
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