Results 31 to 40 of about 457,931 (292)
The Concept of Folic Acid in Health and Disease
Molecules, 2021 Folates have a pterine core structure and high metabolic activity due to their ability to accept electrons and react with O-, S-, N-, C-bounds.
Yulia Shulpekova +9 more
doaj +1 more source
Identification of Transport-critical Residues in a Folate Transporter from the Folate-Biopterin Transporter (FBT) Family [PDF]
Journal of Biological Chemistry, 2010 The Synechocystis Slr0642 protein and its plastidial Arabidopsis (Arabidopsis thaliana) ortholog At2g32040 belong to the folate-biopterin transporter (FBT) family within the major facilitator superfamily. Both proteins transport folates when expressed in Escherichia coli.
Eudes, Aymerick +7 more
openaire +4 more sources
Molecular mechanism of substrate recognition by folate transporter SLC19A1
Cell Discovery, 2022 Folate (vitamin B9) is the coenzyme involved in one-carbon transfer biochemical reactions essential for cell survival and proliferation, with its inadequacy causing developmental defects or severe diseases. Notably, mammalian cells lack the ability to de
Yu Dang +9 more
doaj +1 more source
eLife, 2020 Energy-coupling factor (ECF) transporters mediate import of micronutrients in prokaryotes. They consist of an integral membrane S-component (that binds substrate) and ECF module (that powers transport by ATP hydrolysis).
Inda Setyawati +7 more
doaj +1 more source
Folate receptor alpha is more than just a folate transporter [PDF]
Neurogenesis, 2017 Until recently folate receptor alpha (FRα) has only been considered as a folate transporter. However, a novel role of FRα as a transcription factor was reported by our lab. More recently our lab showed a novel pleiotropic role of FRα: (a) direct transcriptional activation of Oct4, Sox2, and Klf4 genes; and (b) repression of biogenesis of miRNAs that ...
Vineet, Mohanty +3 more
openaire +2 more sources
Heliyon, 2021 Cancer is one of the main causes of human mortality worldwide and novel chemotherapeutics are required due to the limitations of conventional cancer therapies.
Ali Razaghi +4 more
doaj +1 more source
Folate transporter dynamics and therapy with classic and tumor-targeted antifolates
Scientific Reports, 2021 There are three major folate uptake systems in human tissues and tumors, including the reduced folate carrier (RFC), folate receptors (FRs) and proton-coupled folate transporter (PCFT). We studied the functional interrelationships among these systems for
Carrie O’Connor +7 more
doaj +1 more source
The mechanism of folate transport in rabbit reticulocytes [PDF]
Journal of Clinical Investigation, 1972 Folate transport in phenylhydrazine-induced rabbit reticulocytes was studied with the non-metabolized folate-analog, methotrexate. The time-course of methotrexate uptake into a mixed population of reticulocytes and mature erythrocytes is a two-component process consisting of a small, but rapid, initial uptake phase followed by a much slower uptake ...
W F, Bobzien, I D, Goldman
openaire +2 more sources
Protective effects of pyrroloquinoline quinone in brain folate deficiency
Fluids and Barriers of the CNS, 2023 Background Folates (Vitamin B9) are critical for normal neurodevelopment and function, with transport mediated by three major pathways: folate receptor alpha (FRα), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC).
Vishal Sangha +3 more
doaj +1 more source
Folate catabolites in spot urine as non-invasive biomarkers of folate status during habitual intake and folic acid supplementation. [PDF]
, 2013 Folate status, as reflected by red blood cell (RCF) and plasma folates (PF), is related to health and disease risk. Folate degradation products para-aminobenzoylglutamate (pABG) and para-acetamidobenzoylglutamate (apABG) in 24 hour urine have recently ...
Berthold Koletzko (144194) +36 more
core +2 more sources