Results 41 to 50 of about 457,931 (292)

Novel localization of folate transport systems in the murine central nervous system

Fluids and Barriers of the CNS, 2022
Background Folates are a family of B9 vitamins that serve as one-carbon donors critical to biosynthetic processes required for the development and function of the central nervous system (CNS) in mammals.
Vishal Sangha, Md. Tozammel Hoque, Jeffrey T. Henderson, Reina Bendayan   +3 more
doaj   +1 more source

Tetrahydrofolate Recognition by the Mitochondrial Folate Transporter [PDF]

Journal of Biological Chemistry, 2011
A mitochondrial carrier family (MCF) of transport proteins facilitates the transfer of charged small molecules across the inner mitochondrial membrane. The human genome has ∼50 genes corresponding to members of this family. All MCF proteins contain three repeats of a characteristic and conserved PX(D/E)XX(K/R) motif thought to be central to the ...
Scott A, Lawrence, John C, Hackett, Richard G, Moran   +2 more
openaire   +2 more sources

Metabolic effects of a high-fat diet post-weaning after low maternal dietary folate during pregnancy and lactation [PDF]

, 2014
Scope Investigate the influence of low-folate supply during pregnancy and lactation on obesity and markers of the metabolic syndrome in offspring, and how provision of a high-fat diet post weaning may exacerbate the resultant phenotype.
Sabine A. S. Langie, Caroline Manus, Jill A. McKay, Mckay, Jill A., Maxwell, Ross J., Manus, Caroline, Dianne Ford, Maxwell, Ross, Long Xie, Ross J. Maxwell, Langie, Sabine A.S.; id_orcid, Xie, Long, Mathers, John C., McKay, Jill, Langie, Sabine, Ford, Dianne, John C. Mathers   +16 more
core   +1 more source

Membrane Transport of Folate Compounds

Journal of Nutritional Science and Vitaminology, 1992
All eukaryotic cells and some prokaryotes that are unable to synthesize folic acid utilize membrane-associated transport systems for acquisition of the pre-formed vitamin or its coenzyme forms from external sources. These transport systems, in addition to providing folates essential for cell replication, are also important because of their role in the ...
HUENNEKENS, F. M., VITOLS, K. S., POPE, L. E., FAN, J.   +3 more
openaire   +2 more sources

Placental Folate Transport during Pregnancy [PDF]

Bioscience, Biotechnology, and Biochemistry, 2008
The aim of this study was to elucidate the mechanism of folate transport in the placenta over the course of pregnancy. We found that folate receptor alpha (FRalpha) and reduced folate carrier (RFC) localized on the apical side of human placental villi.
YASUDA, Satoru, HASUI, Satoko, YAMAMOTO, Chiaki, YOSHIOKA, Chihiro, KOBAYASHI, Masaki, ITAGAKI, Shirou, HIRANO, Takeshi, ISEKI, Ken   +7 more
openaire   +2 more sources

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Physiological responses to folate overproduction in Lactobacillus plantarum WCFS1 [PDF]

, 2010
Background Using a functional genomics approach we addressed the impact of folate overproduction on metabolite formation and gene expression in Lactobacillus plantarum WCFS1.
Vos, W.M., de, Willem M de Vos, Smid Eddy J, Eddy J Smid, Smid, E.J., Faijes Magda, Vos, R.C.H., de, Mars Astrid E, de Vos, R.C.H.., Klaus, M.J., Molenaar, D., Mars, A.E., Sebastian MJ Klaus, Molenaar, D.; id_orcid, Hanson, A.D., Wegkamp Arno, Douwe Molenaar, Astrid E Mars, Wegkamp, H.B.A., Molenaar Douwe, Klaus, S.M.J., Hanson Andrew D, Wegkamp, A., Magda Faijes, Faijes, M., Vos, W.M., Arno Wegkamp, de Vos Willem M, de Vos Ric CH, Andrew D Hanson, Klaus Sebastian MJ, Ric CH de Vos   +31 more
core   +1 more source

New insights into methotrexate accumulation in leukemia cells in vivo

Molecular & Cellular Oncology, 2021
Measuring the amount of methotrexate polyglutamates (MTXPG) in leukemia cells after high-dose methotrexate (HDMTX) revealed that molecular subtype and lineage of acute lymphoblastic leukemia (ALL), the ratio of expression of folate influx and efflux ...
Elixabet Lopez-Lopez, William E. Evans
doaj   +1 more source

Maternal Folic Acid Supplementation Improves the Intestinal Health of Offspring Porcine by Promoting the Proliferation and Differentiation of Intestinal Stem Cells

Animals, 2023
Maternal folic acid intake has important effects on offspring growth and development. The mechanism involved in the renewal of intestinal epithelial cells remains unclear.
Yuhui Zhang, Xiaofeng Zhang, Jianjun Chen, Shouchuan Jiang, Yu Han, Huahua Du   +5 more
doaj   +1 more source

Intracellular Metabolomics Identifies Efflux Transporter Inhibitors in a Routine Caco-2 Cell Permeability Assay—Biological Implications

Cells, 2022
Caco-2 screens are routinely used in laboratories to measure the permeability of compounds and can identify substrates of efflux transporters. In this study, we hypothesized that efflux transporter inhibition of a compound can be predicted by an ...
Afia Naseem, Akos Pal, Sharon Gowan, Yasmin Asad, Adam Donovan, Csilla Temesszentandrási-Ambrus, Emese Kis, Zsuzsanna Gaborik, Gurdip Bhalay, Florence Raynaud   +9 more
doaj   +1 more source