Results 61 to 70 of about 457,931 (292)

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Angewandte Chemie, EarlyView.
This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu   +3 more
wiley   +2 more sources

Luteolin Enhances Choroid Plexus 5-MTHF Brain Transport to Promote Hippocampal Neurogenesis in LOD Rats

Frontiers in Pharmacology, 2022
Folates, provided by food, are commonly used antidepressant synergists in late-onset depression (LOD). However, increased intake of folic acid in the elderly population might lead to the accumulation of unmetabolized folic acid in the systemic ...
Hui-Zhen Li, Kai-Ge Liu, Ning-Xi Zeng, Xiao-Feng Wu, Wen-Jun Lu, Han-Fang Xu, Can Yan, Li-Li Wu   +7 more
doaj   +1 more source

Package delivered: folate receptor-mediated transporters in cancer therapy and diagnosis

Chemical Science
Neoplasias pose a significant threat to aging society, underscoring the urgent need to overcome the limitations of traditional chemotherapy through pioneering strategies. Targeted drug delivery is an evolving frontier in cancer therapy, aiming to enhance
Mohsen Ahmadi, C. Ritter, T. von Woedtke, S. Bekeschus, K. Wende   +4 more
semanticscholar   +1 more source

Utilization of cognitive support in episodic free recall as a function of apolipoprotein E and vitamin B12 or folate among adults aged 75 years and older [PDF]

, 2004
Apolipoprotein E (APOE), vitamin B12, and folate were examined in relation to free recall among 167 community-based older adults. Cognitive support at encoding and retrieval was also taken into account.
Kivipelto, M, Wahlin, A, Bunce, D
core   +3 more sources

Folate homeostasis of cancer cells affects sensitivity to not only antifolates but also other non-folate drugs: effect of MRP expression

Pteridines, 2013
Sensitivity to antifolates can be decreased by endogenous or exogenous folates. Leucovorin protects cancer patients against toxicity of the dihydrofolate reductase inhibitor methotrexate (MTX), while folic acid is used to protect rheumatoid arthritis ...
Peters Godefridus J., Kathmann Ietje, Lemos Clara, Hooijberg Jan Hendrik, Losekoot Nienke, Jansen Gerrit   +5 more
doaj   +1 more source

Energy-coupling factor transporters: exploration of the mechanism of vitamin uptake and inhibitory potential of novel binders [PDF]

, 2021
This thesis presents investigations of small molecule ligands that inhibit vitamin uptake by Energy Coupling Factor (ECF) transporters, which form a subclass of ATP-binding cassette (ABC) transporters.
Setyawati, Inda; id_orcid, Inda Setyawati, null null   +2 more
core   +1 more source

Cross‐Scale Hierarchical Targeted Delivery System Based on Small‐Scale Magnetic Robots

Advanced Robotics Research, EarlyView.
This article reviews a cross‐scale hierarchical targeted delivery system that integrates magnetic continuum robots and magnetic microrobots. By combining rapid long‐range navigation with precise microscale targeting, the system overcomes key limitations of single‐scale approaches.
Junjian Zhou, Zhiqiang Chen, Yuanbiao Ma, Zhiqiang Tang, Qianqian Wang   +4 more
wiley   +1 more source

African animal trypanocide resistance: A systematic review and meta-analysis

Frontiers in Veterinary Science, 2023
BackgroundAfrican animal trypanocide resistance (AATr) continues to undermine global efforts to eliminate the transmission of African trypanosomiasis in endemic communities. The continued lack of new trypanocides has precipitated drug misuse and overuse,
Keneth Iceland Kasozi, Keneth Iceland Kasozi, Ewan Thomas MacLeod, Susan Christina Welburn, Susan Christina Welburn   +4 more
doaj   +1 more source

Performance, serum biochemical responses, and gene expression of intestinal folate transporters of young and older laying hens in response to dietary folic acid supplementation and challenge with Escherichia coli lipopolysaccharide.

Poultry Science, 2014
The present study was conducted to investigate the effects of dietary folic acid (FA) supplementation on performance, serum biochemical indices, and mRNA abundance of intestinal folate transporters in young and older laying hens after acute ...
M. Jing, P. Munyaka, G. Tactacan, J. Rodríguez-Lecompte, K. O, J. D. House   +5 more
semanticscholar   +1 more source

Transport of Folates and Antifolates in Liver

Experimental Biology and Medicine, 1993
The characteristics and mechanisms of hepatic transport of folates and antifolate cancer drugs, for example, methotrexate, have been studied in perfused liver, isolated hepatocytes (in both freshly isolated cells and in primary cell culture), and membrane vesicles isolated from the basolateral membrane.
openaire   +2 more sources