Plasma membrane folate transport in fungi and plants is mediated by members of the oligopeptide transporter (OPT) family. [PDF]
Biochem JFolates are essential for all organisms. They are acquired either through de novo biosynthesis or from the diet. Yeast, fungi and plants make their own folates and it has not been clear if plasma membrane folate transporters exist in these organisms ...
Vashist N +5 more
europepmc +2 more sources
Folate receptor overexpression induces toxicity in a diet-dependent manner in C. elegans
Scientific ReportsFolate receptor (FR) alpha (FOLR1) and beta (FOLR2) are membrane-anchored folate transporters that are expressed at low levels in normal tissues, while their expression is strongly increased in several cancers.
Bideep Shrestha +2 more
doaj +2 more sources
Drugs inducing interstitial lung disease: in silico analysis of their structures and targets [PDF]
Molecular MedicineBackground The molecular mechanisms underlying many drug-induced diseases, namely, the adverse effects caused by medications, remain poorly understood. As we consider that adverse effects result from the unintended targets of a drug, we aimed to clarify ...
Mao Tanabe +3 more
doaj +2 more sources
Epi-nutrients in the oviductal environment: Folate levels and differential gene expression of its receptors and transporters in the bovine oviduct. [PDF]
Theriogenology, 2018 Recent studies have demonstrated that the oviductal environment plays an active role in modulating the epigenetic marks of the preimplantation embryo genome, but the molecular factors that mediate this epigenetic effect are unknown.
E. V. García +3 more
semanticscholar +2 more sources
PharmaceuticsA large percentage (~60%) of prescription drugs and new molecular entities are designed for oral delivery, which requires passage through a semi-impervious membrane bilayer in the gastrointestinal wall.
Kshitee Kharve +3 more
doaj +2 more sources
High folate receptor expression is associated with aggressive features in prostate cancer with low prostate‐specific membrane antigen expression [PDF]
BJUI CompassObjective This work aimed to analyse the expression of and correlation between folate transporters FOLR1, FOLR2, SLC19A1 (reduced folate carrier, RFC), and FOLH1 (PSMA mRNA) in a large cohort of prostate cancer samples, with the goal of better ...
Ashorne K. Mahenthiran +8 more
doaj +2 more sources
Congenital Heart Disease and Genetic Changes in Folate/Methionine Cycles
GenesCongenital heart disease is one of the most common congenital malformations and thus represents a considerable public health burden. Hence, the identification of individuals and families with an increased genetic predisposition to congenital heart ...
Nataša Karas Kuželički, Bojan Doljak
semanticscholar +2 more sources
American Journal of Clinical Nutrition, 2023 BACKGROUND Folic acid supplementation during the periconceptional period reduces risk of neural tube defects in infants, but concern over chronic folic acid exposure remains.
Colleen C. Farrell +11 more
semanticscholar +1 more source
Author correction to “The upregulated intestinal folate transporters direct the uptake of ligand-modified nanoparticles for enhanced oral insulin delivery” [Acta Pharm Sin B 12 (2022) 1460–1472] [PDF]
Acta Pharmaceutica Sinica BJingyi Li +11 more
doaj +2 more sources
Biochemical and molecular mechanisms of folate transport in rat pancreas; interference with ethanol ingestion. [PDF]
PLoS ONE, 2011 Folic acid is an essential nutrient that is required for one-carbon biosynthetic processes and for methylation of biomolecules. Deficiency of this micronutrient leads to disturbances in normal physiology of cell.
Nissar Ahmad Wani +2 more
doaj +1 more source