Results 11 to 20 of about 457,931 (292)

Reduced expression of folate transporters in kidney of a rat model of folate oversupplementation. [PDF]

Genes Nutr, 2014
Folic acid is the key one-carbon donor required for de novo nucleotide and methionine synthesis. Its deficiency is associated with megaloblastic anemia, cancer and various complications of pregnancy. However, its supplementation results in reduction of neural tube defects and prevention of several types of cancer.
Thakur S, Thakur SD, Wani NA, Kaur J.
europepmc   +5 more sources

Ischemia-Reperfusion Injury Reduces Kidney Folate Transporter Expression and Plasma Folate Levels [PDF]

Frontiers in Immunology, 2021
Acute or chronic kidney disease can cause micronutrient deficiency. Patients with end-stage renal disease, kidney transplantation or on dialysis have reduced circulating levels of folate, an essential B vitamin.
Cheng Yang, Cheng Yang, Charith U. B. Wijerathne, Charith U. B. Wijerathne, Guo-wei Tu, Connie W. H. Woo, Yaw L. Siow, Yaw L. Siow, Yaw L. Siow, Susara Madduma Hewage, Susara Madduma Hewage, Kathy K. W. Au-Yeung, Kathy K. W. Au-Yeung, Tongyu Zhu, Tongyu Zhu, Karmin O, Karmin O, Karmin O   +17 more
doaj   +2 more sources

Structure-Guided Optimization of Small-Molecule Folate Uptake Inhibitors Targeting the Energy-Coupling Factor Transporters [PDF]

Journal of Medicinal Chemistry, 2021
Here, we report on a potent class of substituted ureidothiophenes targeting energy-coupling factor (ECF) transporters, an unexplored target that is not addressed by any antibiotic in the market.
A. Kiefer, Spyridon Bousis, M. Hamed, Eleonora Diamanti, Jörg Haupenthal, A. Hirsch   +5 more
semanticscholar   +3 more sources

STRUCTURAL COMPARISON OF PROKARYOTIC AND EUKARYOTIC FOLATE TRANSPORTERS BY COMPUTATIONAL APPROACH [PDF]

Asian Journal of Pharmaceutical and Clinical Research, 2018
Objective: In silico approach has particularly drawn attention in providing a realistic representation needed to understand the fundamental molecular structure of a transporter.
D. Agarwal, A. Jha
semanticscholar   +3 more sources

Maternal folate deficiency causes inhibition of mTOR signaling, down-regulation of placental amino acid transporters and fetal growth restriction in mice

Scientific Reports, 2017
Maternal folate deficiency is linked to restricted fetal growth, however the underlying mechanisms remain to be established. Here we tested the hypothesis that mTOR functions as a folate sensor in vivo in mice and that maternal folate deficiency inhibits
Fredrick J. Rosario, Peter W. Nathanielsz, Theresa L. Powell, Thomas Jansson   +3 more
doaj   +3 more sources

Relationship between folate transporters expression in human placentas at term and birth weights. [PDF]

Placenta, 2016
BACKGROUND Adequate folate levels are essential for successful pregnancy outcomes. We aimed to study the relationship between placental mRNA and protein levels of folate transporters to birth weight.
Lorena Caviedes, G. Iñiguez, P. Hidalgo, J. Castro, Erika Castaño, M. Llanos, S. Hirsch, A. Ronco   +7 more
semanticscholar   +2 more sources

Enantioselective Drug Recognition by Drug Transporters

Molecules, 2018
Drug transporters mediate the absorption, tissue distribution, and excretion of drugs. The cDNAs of P-glycoprotein, multidrug resistance proteins (MRPs/ABCC), breast cancer resistance protein (BCRP/ABCG2), peptide transporters (PEPTs/SLC15), proton ...
Yuichi Uwai
doaj   +2 more sources

Effects of folic acid on body folate status, ovarian function, and organ indexes of offspring during embryonic stage

Frontiers in Veterinary Science
This experiment aimed to investigate the effect of dietary folic acid supplementation on maternal folate status and ovarian function in female broiler breeders.
Jianfei Zhao, Zhongqian Lu, Jialin Wu, Yufei Zhu, Yufei Zhu   +4 more
doaj   +2 more sources

Regulation of folate transport at the mouse arachnoid barrier

Fluids and Barriers of the CNS
Background Folates are a family of B9 vitamins essential for normal growth and development in the central nervous system (CNS). Transport of folates is mediated by three major transport proteins: folate receptor alpha (FRα), proton-coupled folate ...
Vishal Sangha, Sara Aboulhassane, Reina Bendayan   +2 more
doaj   +2 more sources

Folate metabolism in plants: an Arabidopsis homolog of the mammalian mitochondrial folate transporter mediates folate import into chloroplasts.

The Journal of biological chemistry, 2005
The distribution of folates in plant cells suggests a complex traffic of the vitamin between the organelles and the cytosol. The Arabidopsis thaliana protein AtFOLT1 encoded by the At5g66380 gene is the closest homolog of the mitochondrial folate transporters (MFTs) characterized in mammalian cells.
Bedhomme, Mariette, Hoffmann, Michaela, Mccarthy, Erin A., Gambonnet, Bernadette, Moran, Richard G., Rébeillé, Fabrice, Ravanel, Stéphane   +6 more
openaire   +7 more sources