Results 171 to 180 of about 457,931 (292)

Application and Research Progress of Nucleic Acid‐Based Drug Delivery Systems in the Treatment of Intracerebral Hemorrhage

MedComm – Biomaterials and Applications, Volume 5, Issue 4, December 2026.
This review summarizes recent advances in NADDS for treating ICH, highlighting the advantages and applications of key delivery technologies including lipid nanoparticles, exosomes, and DNA nanostructures. ABSTRACT Intracerebral hemorrhage (ICH) is a devastating stroke subtype associated with high mortality and neurological disability, yet effective ...
Jingyan Wang, Xuejiao Zeng, Pengyu Niu, Jinjin Shi, Wenyan Yu   +4 more
wiley   +1 more source

Mucuna pruriens as a Sustainable Functional Food: Applications From Seed to Product

Modern Agriculture, Volume 4, Issue 2, December 2026.
This review highlights Mucuna pruriens as a nutrient‐rich legume with significant nutritional, therapeutic, and agricultural value. Its protein‐rich seeds contain essential minerals and L‐DOPA, but high antinutritional compounds require effective processing before consumption.
Crossby Osei Tutu, Reuben Acheampong, Papa Toah Akonor, Bernard Kwabena Asiedu, Rexford Obeng, Anthonia Helga Andoh‐Odoom, Dora Duah‐Bisiw, Jacob Ulzen, Michael Wiafe‐Kwagyan, Nii Korley Kortei, Justice Owusu‐Bempah   +10 more
wiley   +1 more source

The Major Facilitative Folate Transporters Solute Carrier 19A1 and Solute Carrier 46A1: Biology and Role in Antifolate Chemotherapy of Cancer

Drug Metabolism And Disposition, 2014
L. Matherly, M. Wilson, Z. Hou
semanticscholar   +1 more source

Microbial Mechanisms and Sensory Outcomes of Flavor Development in Fermented Plant‐Based Proteins

Sustainable Food Proteins, Volume 4, Issue 4, December 2026.
Fermentation improves the flavor and consumer appeal of plant‐based proteins by reducing off‐flavors and generating desirable taste and aroma compounds. This review summarizes microbial mechanisms of flavor development, factors influencing sensory quality, and emerging opportunities in precision fermentation, flavoromics, and microbial engineering ...
Nancy D. Asen
wiley   +1 more source

Minimally processed, human‐grade diet alters canine epigenetic ageing: Results from a pilot study

Veterinary Record Open, Volume 13, Issue 2, December 2026.
Abstract Background Diet plays a critical role in promoting wellness and longevity in both humans and canines. Epigenetic ageing clocks have emerged as accurate tools for assessing biological ageing and evaluating dietary and lifestyle interventions in humans and mice.
Aimee Chen, Wei Guo, Janina A. Krumbeck, Dan Su, Vincent Michels, Xiaojing Yang   +5 more
wiley   +1 more source

Metformin Use Is Associated With Better Cognitive Performance in Older Adults With Type 2 Diabetes: Exploratory Analysis of Vitamin B12 and Methylmalonic Acid Pathways in NHANES 2011–2014

Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 11808-11820, December 2026.
ABSTRACT Aims Metformin, the first‐line treatment for Type 2 diabetes mellitus (T2DM), may be neuroprotective but also lowers serum vitamin B12 by ~19%, raising concern that B12 depletion could offset this benefit. We used modern exploratory causal mediation methods in a nationally representative sample to test whether vitamin B12 and methylmalonic ...
Danial Fotros, Hanieh Sakhdari, Andrew C. Shin   +2 more
wiley   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, Volume 38, Issue 61, 2 November 2026.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3716-3732, November 2026.
Dolutegravir underpins modern first‐ and second‐line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the pharmacogenomics of dolutegravir, focusing on pharmacokinetics and pharmacodynamics, and methodological limitations ...
Ronald Kiguba, Mishael Ssesanga, Munir Pirmohamed   +2 more
wiley   +1 more source

Phenotype-Specific Pharmacogenetic Patterns of Methotrexate Neurotoxicity in Pediatric Acute Lymphoblastic Leukemia. [PDF]

J Clin Med
Gómez-Román J, Restrepo JC, González LM, González-Rodríguez L, Lacombe-Antoneli Á, Gutiérrez-Martín Y, de la Maya MD, Mesegué M, Dapena JL, Carbone A, González Martínez B, Lendínez Molinos F, Molinés Honrubia A, Abós García M, García Morín M, Navarro Noguera S, Sagaseta de Ilurdoz M, Astigarraga I, Baro Fernández M, Verdú Amorós J, Regueiro A, Ramírez Orellana M, Soler JLF, González Muñiz S, Nieto AC, Torrent Español M, González Méndez H, Vagace JM, Gervasini G.   +28 more
europepmc   +1 more source

Suspected Pentalogy of Cantrell With Ectopia Cordis in a Newborn: Diagnostic and Management Challenges in a Low Resource Setting in Northern Tanzania

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Suspected Pentalogy of Cantrell with ectopia cordis carries very high neonatal mortality. In low‐resource settings, absent antenatal ultrasound and limited access to imaging and pediatric cardiac surgery reduce diagnostic certainty and survival.
Tabitha Mshanga, Lightness Chuwa, Kajal Jethwa, Ronald Mbwasi   +3 more
wiley   +1 more source