Results 151 to 160 of about 457,931 (292)

Expression and characterization of pantothenate energy‐coupling factor transporters as an anti‐infective drug target

open access: yesProtein Science
This study investigates the potential of energy‐coupling factor (ECF) transporters as promising anti‐infective targets to combat antimicrobial resistance (AMR).
Atanaz Shams   +7 more
semanticscholar   +1 more source

Extracellular vesicles in pharmacology: Innovations in drug delivery and therapeutic applications in cancer

open access: yesBritish Journal of Pharmacology, EarlyView.
Extracellular vesicles (EVs) are a diverse population of membrane nanoparticles secreted by nearly all cell types, playing a key role in intercellular communication by transferring bioactive macromolecular cargo. In cancer, EVs shape both the local tumour microenvironment and distant premetastatic niches.
Evangelia Pantazaka   +3 more
wiley   +1 more source

Metformin Use During Pregnancy and Early‐Life Nutritional Status: A Systematic Review of Randomized Clinical Trials

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background and Aims Metformin is increasingly used to treat gestational diabetes mellitus and other insulin‐resistant conditions during pregnancy. Because it crosses the placenta, concerns remain regarding its potential effects on offspring growth and metabolic programming.
Otilia Perichart‐Perera   +2 more
wiley   +1 more source

Periodontal Salutogenesis: Why Are Some People Resistant to Oral Microbial Dysbiosis and Destructive Inflammation?

open access: yesJournal of Periodontal Research, EarlyView.
Emerging evidence suggests that periodontal health is not simply the absence of disease, but the result of a dynamic interaction between biological resilience, healthy lifestyles, adaptive coping mechanisms, and supportive environments. This results in a strong sense of coherence, which is not only a psychological state but also a biological state ...
Bruno G. Loos   +4 more
wiley   +1 more source

Serum Folate Concentration Corresponding to the Red Blood Cell Folate Threshold for Increased Risk of Neural Tube Defects Among Ethiopian Women of Reproductive Age

open access: yesMaternal &Child Nutrition, EarlyView.
ABSTRACT Neural tube defects (NTDs) are severe birth defects linked to insufficient maternal folate status during early pregnancy. Red blood cell (RBC) folate concentration is the recommended biomarker for predicting NTD risk, with a threshold of 748 nmol/L using the US Centers for Disease Control and Prevention (CDC) microbiological assay. However, in
Biniyam Tesfaye   +5 more
wiley   +1 more source

Mutations in SUMO conjugating enzyme reveal contributions of sumoylation to plant stress resilience and yield

open access: yesNew Phytologist, EarlyView.
Mutations in small ubiquitin‐related modifier (SUMO) conjugating enzyme that increase or decrease functionality reveal SUMO contributions to growth and stress resilience. Summary Small ubiquitin‐related modifier (SUMO) conjugation is a fundamental process in all metazoa, with multiple roles in development and stress responses.
Lilian Nehlin   +6 more
wiley   +1 more source

Identification of Genetic Loci Conveying Resistance to Fusarium oxysporum f. sp. ciceris Race 0 in Chickpea

open access: yesPlant Breeding, EarlyView.
ABSTRACT Chickpea (Cicer arietinum L.) is a legume that is widely consumed around the world due to its nutritional content. Fusarium oxysporum f. sp. ciceris is a serious, destructive pathogen that causes fusarium wilt disease and affects chickpea production.
Selda Kurt Ozyaramis   +5 more
wiley   +1 more source

Novel contributions to understanding the mechanism of folate transport and anti-folate resistance in Plasmodium falciparum

open access: yes, 2008
The primary focus of the PhD thesis has exclusively been on studies on Plasmodium falciparum with a remit to build a clear understanding on some of the critical and relevant questions relating to folates transport and antifolates resistance.
Ochong, Edwin Omondi
core  

Phototherapies mediated by metallic nanoparticles and near‐infrared radiation in skin cancer: A systematic review

open access: yesPhotochemistry and Photobiology, EarlyView.
Recent studies demonstrate that near‐infrared (NIR—750–980 nm)‐mediated photodynamic (PDT) and photothermal (PTT) therapies, combined with metallic nanoparticles (MNPs), show promising results against skin cancer, particularly melanoma, in both in vitro and in vivo models.
Tamyris Devincenzi   +3 more
wiley   +1 more source

Dietary amino acid patterns and epilepsy among the PERSIAN cohort population: A cross‐sectional study

open access: yesExperimental Physiology, EarlyView.
Abstract Epilepsy is characterized by the occurrence of at least two unprovoked seizures occurring more than 24 h apart, reflecting a predisposition to recurrent epileptic events. The role of dietary amino acids (AAs) in epilepsy is not clearly understood. To the best of our knowledge, this study is the first to investigate the link between the odds of
Hamid Abbasi   +4 more
wiley   +1 more source

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