Results 141 to 150 of about 457,931 (292)

The Effects of Disinfection Byproduct 2,6-Dichloro-1,4-benzoquinone on the Cyanobacterium Microcystis aeruginosa: From the Perspectives of Biochemistry and Non-Targeted Metabolomics

Toxics
2,6-Dichloro-1,4-benzoquinone (2,6-DCBQ) is an emerging chlorinated disinfection byproduct (DBP) in bodies of water. However, this compound poses an unknown toxic effect on cyanobacteria.
Tianqi Zhang, Zhaoyang Wang, Liang Wu, Chaonan Liu, Liang Meng, Fuxiang Tian, Meifang Hou, Haizhuan Lin, Jing Ye   +8 more
doaj   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

Beyond folate antagonism: the unique pharmacological blueprint of methotrexate

International Journal of Basic & Clinical Pharmacology
Methotrexate (MTX) possesses a uniquely complex pharmacological profile characterized by nonlinear pharmacokinetics, saturable absorption, transporter-dependent distribution, and intracellular polyglutamation, all of which contribute to substantial ...
A. Menon, P. Murugesan, P. Tamilarasan, S. Palanisamy, A. Parthasarathy   +4 more
semanticscholar   +1 more source

Advances in research on layered double hydroxides for biomedical applications

Smart Molecules, EarlyView.
Layered double hydroxides (LDHs) are pH‐responsive nanomaterials with broad biomedical applications. This review summarizes LDH synthesis methods and compares their advantages. It highlights LDHs' progress in cancer therapy, including chemo‐photothermal, chemo‐immunotherapy, and photodynamic‐immunotherapy combinations and their potential in bone repair.
Xinhui Yang, Zhiping Zhang, Zhao Wang, Hao Zhang, Yen Leng Pak, Yingying Jing, Yurong Guo, Fang Li, Xiao Wang, Quanxiang Han, Lei Yu, Xuejiao Li, Xing Gao, Jibin Song   +13 more
wiley   +1 more source

Smart mesoporous silica nanoparticles for precision cancer therapy: Tumor targeting and stimuli‐responsive controlled release

Smart Molecules, EarlyView.
Smart mesoporous silica nanoparticles integrate tunable pore structures, molecular gates, targeting ligands, and stimuli‐responsive components to achieve controlled drug release for precision cancer therapy. This review highlights design principles, therapeutic applications, and future directions in immunotherapy, biodegradability, biosafety, and ...
Majdi Al‐Amili, Lei Lei, Zhu Jin
wiley   +1 more source

Engineering metal‐organic framework‐based smart porous nanoplatforms for targeted therapy and theranostic applications

Smart Molecules, EarlyView.
MOFs offer high porosity and tunability for biomedical applications, especially in cancer therapy via ROS generation and targeted delivery. Though toxicity, stability, and scalability remain key clinical challenges. Drug loading in MOFs exceeds 60%–70% with controlled release behavior.
Jagabandhu Bag, Subhasis Banerjee, Sabyasachi Banerjee, Sourav De, S. K. Ashok Kumar, Yan‐Jye Shyong, Subhankar Mukhopadhyay   +6 more
wiley   +1 more source

Engineering ApoE‐Mimetic HDL‐Like Nanoparticles for Glioblastoma‐Targeted Theranostics

Small Methods, EarlyView.
An ApoE‐mimetic peptide enables the stable formation of sub‐30 nm HDL‐like nanoparticles (ApoEm‐PLP) that simultaneously engage multiple lipoprotein receptors. This multivalent receptor interaction facilitates the transport of ApoEm‐PLP into brain and enhances targeted delivery of ApoEm‐PLP to glioblastoma, resulting in uniform intratumoral porphyrin ...
Hanyi Weng, Rick Wentao Cui, Ling Xi Gong, Ashley Qian, Lili Ding, Nahyun Kwon, Yiming Yang, Yulin Mo, Tiffany Ho, Madeline K. Brown, Maneesha Amrita Rajora, Juan Chen, Gang Zheng   +12 more
wiley   +1 more source

Severe hematologic toxicity after low-dose methotrexate in ectopic pregnancy: role of MTHFR polymorphism and drug interaction - a case report and literature review

Frontiers in Pharmacology
BackgroundLow-dose methotrexate (MTX) is a standard treatment for ectopic pregnancy. While generally safe, it can rarely cause life-threatening hematologic toxicity.
Xiaojie Huang, Fangjie He, Yanhong Deng, Shengying Shi   +3 more
doaj   +1 more source

Seasonal Dynamics of Community and Function of Gut Microbiome in Taihangshan Macaque (Macaca mulatta tcheliensis): Inferred From Metagenomic Data

Integrative Zoology, EarlyView.
A total of 435 non‐redundant metagenome‐assembled genomes (MAGs) were obtained from fecal samples of Taihangshan macaque across all four seasons. The alpha diversity of the gut microbiome in spring and winter was significantly higher than in summer and autumn. Furthermore, marked differences were detected in functional pathways and carbohydrate enzymes
Yanyan Zhou, Qi Shao, Chunbo Liu, Jundong Tian, Xiaowen Guan, Xi Zhang, Jiqi Lu   +6 more
wiley   +1 more source

Multi-Tissue Metabolomics Reveals Metabolic Signatures Associated with Lipid Partitioning Between Abdominal Fat and Egg Yolk in Laying Hens

Animals
Fat deposition in laying hens involves lipid synthesis, transport, storage, and allocation across multiple tissues, yet the metabolic links between abdominal fat (AF) and egg yolk (EY) lipid deposition remain unclear.
Wenxin Zhang, Ronglang Cai, Fangren Lan, Guiqin Wu, Guangqi Li, Yiyuan Yan, Ning Yang, Congjiao Sun   +7 more
doaj   +1 more source