Results 131 to 140 of about 457,931 (292)

Characterization of intestinal transporters in human ileal spheroid-derived differentiated cells for the prediction of intestinal drug absorption.

Drug Metabolism And Disposition
This study aimed to characterize the functional properties of human spheroid-derived differentiated cells for absorption, distribution, metabolism, and excretion studies.
Kazuyoshi Michiba, Mana Namai, Yoshiki Hashimoto, O. Shimomura, Yoshihiro Miyazaki, S. Hashimoto, Y. Ohara, Tsuyoshi Enomoto, Tatsuya Oda, K. Maeda, Hiroyuki Kusuhara   +10 more
semanticscholar   +1 more source

Plant‐Derived Natural Product Nanodelivery System in Cancer Therapy

Phytotherapy Research, EarlyView.
This review comprehensively summarizes the recent progress and emerging concepts in nanotechnology‐based delivery systems for plant‐derived natural products, with a particular focus on their application in precision cancer therapy. ABSTRACT Plant‐derived natural products have emerged as important sources of anticancer agents because of their diverse ...
Changqi Shi, LuLu Zhang, Lan Yan, Qi Geng, Li Li, Xiaojuan He, Ning Zhao, Yong Tan, Xiaomeng Zhang, Cheng Lu   +9 more
wiley   +1 more source

Vitamin B12 and folate status during pregnancy among Saudi population [PDF]

T2DM is a growing health problem worldwide. It is now increasingly being diagnosed earlier in life. The factors involved in such an epidemic are complex.
Bawazeer, Nahla M.
core  

Novel contributions to understanding the mechanism of folate transport and anti-folate resistance in Plasmodium falciparum [PDF]

The primary focus of the PhD thesis has exclusively been on studies on Plasmodium falciparum with a remit to build a clear understanding on some of the critical and relevant questions relating to folates transport and antifolates resistance.
Omondi Ochong, Edwin
core   +1 more source

Plant‐Derived Extracellular Vesicles: Biogenesis, Function, and Application in Cancer Immunotherapy

Phytotherapy Research, EarlyView.
This illustration shows the biogenesis pathways of edible and medicinal plant‐derived extracellular vesicles (PDEVs) and their therapeutic effects following uptake in the human body, highlighting their potential for application in cancer immunotherapy. ABSTRACT Plant‐derived extracellular vesicles (PDEVs) are nanoscale, lipid bilayer‐enclosed vesicles ...
Guosheng Li, Mengyu Li, Shujing Liu, Yuan Wei, Chen Wang   +4 more
wiley   +1 more source

Clinical predictors of response to methotrexate in patients with rheumatoid arthritis: A systematic review

Rheumatology &Autoimmunity, EarlyView.
This review integrates clinical, immunological, genetic, and multi‐omic evidence, highlighting dynamic inflammatory and adenosine‐pathway biomarkers and reinforcing treat‐to‐target principles as the most actionable framework for personalized methotrexate therapy.
Joana Ramos Rodrigues, Helena Margarida de Miranda Lemos Romão Donato, Soraia Raquel Loureiro Azevedo, Luís Miguel da Silva Pires, Luís Pedro Bolotinha de Sousa Inês, Manuel Augusto Nunes Vicente Passos Morgado, Ana Filipa de Sousa Pestana Mourão   +6 more
wiley   +1 more source

Serum metabolomics reveals systemic metabolic alterations of Graves’ disease before and after antithyroid drug treatment

Endocrine Connections
Objective: This study aimed to utilize untargeted metabolomics to analyze changes of serum metabolites before and after methimazole treatment in patients with Graves’ disease (GD).
Tiantian Li, Luyang Li, Xinpan Wang, Yue Li, Yingyun Gong, Hongwen Zhou, Xuqin Zheng   +6 more
doaj   +1 more source

Cuminaldehyde downregulates folate metabolism and membrane proteins to inhibit growth of Penicillium digitatum in citrus fruit

Future Postharvest and Food
In our previous study, cuminaldehyde triggered oxidative stress to inhibit growth of Penicillium digitatum in citrus fruit. Here, we examined the molecular mechanism by which it inhibited growth of P. digitatum.
Okwong Oketch Reymick, Dazhao Liu, Xiao-Li Tan, Qiu-Li Ouyang, Neng-Guo Tao   +4 more
semanticscholar   +1 more source

Efficient water‐soluble blue/red‐emissive carbon dots matching plant absorption spectra: Synthesis, tunable control, and their applications in promoting plant growth

Responsive Materials, EarlyView.
Guided by the spectral demand of plant photosystems, this review summarizes the synthesis, emission regulation, dual‐emission design, and gram‐scale production of CDs for agricultural applications. Spectrally matched blue‐ and red‐emissive CDs enhance plant light utilization by converting underutilized light into photosynthetically active radiation and
Yijing Chen, Ziyue Mu, Haoran Zhang, Xuejie Zhang, Wei Li, Bingfu Lei   +5 more
wiley   +1 more source

Effects of short-term supplementation of folic acid and L-5-methyltetrahydrofolate on cell proliferation and the expression of folate transporters in human colorectal adenocarcinoma (Caco2) cells

, 2014
Folate plays a role in the synthesis and repair of DNA and the generation of methyl groups. Folic acid (FA) is a synthetic oxidized form of folate used in food fortification and supplements in Canada.
Hempstock, Wendy
core   +1 more source